Veröffentlichungen Translationale Medizin

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A - C

Agueusop, I., Musholt, P.B., Klaus, B., Hightower, K., Kannt, A.
Short-term variability of the human serum metabolome depending on nutritional and metabolic health status (2020) Scientific reports, 10 (1), 16310. DOI: 10.1038/s41598-020-72914-7

Aguilar, R.C., Salmanton-García, J., Carney, J., Böll, B., Kochanek, M., Jazmati, N., Cornely, O.A., Vehreschild, M.J.G.T.
Clostridioides difficile infections in the intensive care unit: a monocentric cohort study (2020) Infection, 48 (3), 421–427. DOI: 10.1007/s15010-020-01413-8

Allanore, Y., Bozzi, S., Terlinden, A., Huscher, D., Amand, C., Soubrane, C., Siegert, E., Czirják, L., Carreira, P.E., Hachulla, E., Zanatta, E., Li, M., Airò, P., Mendoza, F.A., Rosato, E., Distler, O.
Health Assessment Questionnaire-Disability Index (HAQ-DI) use in modelling disease progression in diffuse cutaneous systemic sclerosis: an analysis from the EUSTAR database (2020) Arthritis research & therapy, 22 (1), 257. DOI: 10.1186/s13075-020-02329-2

Anastasiou, O.E., Thodou, V., Berger, A., Wedemeyer, H., Ciesek, S.
Comprehensive Evaluation of Hepatitis E Serology and Molecular Testing in a Large Cohort (2020) Pathogens (Basel, Switzerland), 9 (2). DOI: 10.3390/pathogens9020137

Anders, M., Anders, B., Kreuzer, M., Zinn, S., Walter, C.
Application of Referencing Techniques in EEG-Based Recordings of Contact Heat Evoked Potentials (CHEPS) (2020) Frontiers in human neuroscience, 14, 559969. DOI: 10.3389/fnhum.2020.559969

Appelt-Menzel, A., Oerter, S., Mathew, S., Haferkamp, U., Hartmann, C., Jung, M., Neuhaus, W., Pless, O.
Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development? (2020) Current protocols in stem cell biology, 55 (1), e122. DOI: 10.1002/cpsc.122

Assmann, G., Köhm, M., Schuster, V., Behrens, F., Mössner, R., Magnolo, N., Oji, V., Burkhardt, H., Hüffmeier, U.
Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups (2020) BMC medical genetics, 21 (1), 102. DOI: 10.1186/s12881-020-01037-7

Bacher, P., Rosati, E., Esser, D., Martini, G.R., Saggau, C., Schiminsky, E., Dargvainiene, J., Schröder, I., Wieters, I., Khodamoradi, Y., Eberhardt, F., Vehreschild, Maria J G T, Neb, H., Sonntagbauer, M., Conrad, C., Tran, F., Rosenstiel, P., Markewitz, R., Wandinger, K.-P., Augustin, M., Rybniker, J., Kochanek, M., Leypoldt, F., Cornely, O.A., Koehler, P., Franke, A., Scheffold, A.
Low-Avidity CD4(+) T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19 (2020) Immunity, 53 (6), 1258-1271.e5. DOI: 10.1016/j.immuni.2020.11.016

Ballo, O., Kreisel, E.-M., Eladly, F., Brunnberg, U., Stratmann, J., Hunyady, P., Hogardt, M., Wichelhaus, T.A., Kempf, V.A.J., Steffen, B., Vehreschild, J.J., Vehreschild, M.J.G.T., Finkelmeier, F., Serve, H., Brandts, C.H.
Use of carbapenems and glycopeptides increases risk for Clostridioides difficile infections in acute myeloid leukemia patients undergoing intensive induction chemotherapy (2020) Annals of hematology, 99 (11), 2547–2553. DOI: 10.1007/s00277-020-04274-1

Baraliakos, X., Sewerin, P., Miguel, E. de, Pournara, E., Kleinmond, C., Wiedon, A., Behrens, F.
Achilles tendon enthesitis evaluated by MRI assessments in patients with axial spondyloarthritis and psoriatic arthritis: a report of the methodology of the ACHILLES trial (2020) BMC musculoskeletal disorders, 21 (1), 767. DOI: 10.1186/s12891-020-03775-4

Basavarajappa, D., Uebbing, S., Kreiss, M., Lukic, A., Suess, B., Steinhilber, D., Samuelsson, B., Rådmark, O.
Dicer up-regulation by inhibition of specific proteolysis in differentiating monocytic cells (2020) Proceedings of the National Academy of Sciences of the United States of America, 117 (15), 8573–8583. DOI: 10.1073/pnas.1916249117

Behrens, F., Rech, J., Thaçi, D., Zinke, S., Rothnie, K.J., Oefner Daamen, C., Leipe, J.
High rates of therapeutic changes in patients with psoriatic arthritis receiving treatment with disease-modifying antirheumatic drugs: a cross-sectional study (2020) Modern rheumatology, 1–23. DOI: 10.1080/14397595.2020.1816597

Behrens, F., Tony, H.-P., Koehm, M., Schwaneck, E.C., Gnann, H., Greger, G., Burkhardt, H., Schmalzing, M.
Correction to: Sustained improvement in work outcomes in employed patients with rheumatoid arthritis during 2 years of adalimumab therapy: an observational cohort study (2020) Clinical rheumatology, 39 (8), 2491. DOI: 10.1007/s10067-020-05168-3

Behrens, F., Tony, H.-P., Koehm, M., Schwaneck, E.C., Gnann, H., Greger, G., Burkhardt, H., Schmalzing, M.
Sustained improvement in work outcomes in employed patients with rheumatoid arthritis during 2 years of adalimumab therapy: an observational cohort study (2020) Clinical rheumatology, 39 (9), 2583–2592. DOI: 10.1007/s10067-020-05038-y

Biehl, L.M., Vehreschild, Maria J G T
Contact precautions: no benefits, no indication (2020) The Lancet. Infectious diseases, 20 (5), 516–517. DOI: 10.1016/S1473-3099(20)30017-7

Blum, L., Geisslinger, G., Parnham, M.J., Grünweller, A., Schiffmann, S.
Natural antiviral compound silvestrol modulates human monocyte-derived macrophages and dendritic cells (2020) Journal of cellular and molecular medicine, 24 (12), 6988–6999. DOI: 10.1111/jcmm.15360

Blum, L., Gul, S., Ulshöfer, T., Henke, M., Krieg, R., Berneburg, I., Thomas, D., Trautmann, S., Kurz, J., Geyer, J., Geisslinger, G., Becker, K., Parnham, M.J., Schiffmann, S.
In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o (2020) Scientific reports, 10 (1), 7534. DOI: 10.1038/s41598-020-64382-w

Bojkova, D., Bechtel, M., McLaughlin, K.-M., McGreig, J.E., Klann, K., Bellinghausen, C., Rohde, G., Jonigk, D., Braubach, P., Ciesek, S., Münch, C., Wass, M.N., Michaelis, M., Cinatl, J., JR
Aprotinin Inhibits SARS-CoV-2 Replication (2020) Cells, 9 (11). DOI: 10.3390/cells9112377

Bojkova, D., Klann, K., Koch, B., Widera, M., Krause, D., Ciesek, S., Cinatl, J., Münch, C.
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets (2020) Nature, 583 (7816), 469–472. DOI: 10.1038/s41586-020-2332-7

Bojkova, D., Wagner, J.U.G., Shumliakivska, M., Aslan, G.S., Saleem, U., Hansen, A., Luxán, G., Günther, S., Pham, M.D., Krishnan, J., Harter, P.N., Ermel, U.H., Frangakis, A.S., Milting, H., Zeiher, A.M., Klingel, K., Cinatl, J., Dendorfer, A., Eschenhagen, T., Tschöpe, C., Ciesek, S., Dimmeler, S.
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes (2020) Cardiovascular research, 116 (14), 2207–2215. DOI: 10.1093/cvr/cvaa267

Bojkova, D., Westhaus, S., Costa, R., Timmer, L., Funkenberg, N., Korencak, M., Streeck, H., Vondran, F., Broering, R., Heinrichs, S., Lang, K.S., Ciesek, S.
Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes (2020) Cells, 9 (4). DOI: 10.3390/cells9041003

Brandt, S.C., Ellinger, B., van Nguyen, T., Harder, S., Schlüter, H., Hahnke, R.L., Rühl, M., Schäfer, W., Gand, M.
Aspergillus sydowii: Genome Analysis and Characterization of Two Heterologous Expressed, Non-redundant Xylanases (2020) Frontiers in microbiology, 11, 2154. DOI: 10.3389/fmicb.2020.573482

Brunst, S., Kramer, J.S., Kilu, W., Heering, J., Pollinger, J., Hiesinger, K., George, S., Steinhilber, D., Merk, D., Proschak, E.
Systematic Assessment of Fragment Identification for Multitarget Drug Design (2020) ChemMedChem . DOI: 10.1002/cmdc.202000858

Bütikofer, L., Varisco, P.A., Distler, O., Kowal-Bielecka, O., Allanore, Y., Riemekasten, G., Villiger, P.M., Adler, S.
ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis-a EUSTAR analysis (2020) Arthritis research & therapy, 22 (1), 59. DOI: 10.1186/s13075-020-2141-2

Chachulski, L., Windshügel, B.
LEADS-FRAG: A Benchmark Data Set for Assessment of Fragment Docking Performance (2020) Journal of chemical information and modeling, 60 (12), 6544–6554. DOI: 10.1021/acs.jcim.0c00693

Chaikuad, A., Pollinger, J., Rühl, M., Ni, X., Kilu, W., Heering, J., Merk, D.
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms (2020) International journal of molecular sciences, 21 (22). DOI: 10.3390/ijms21228457

Charoo, N.A., Abdallah, D.B., Parveen, T., Abrahamsson, B., Cristofoletti, R., Groot, D.W., Langguth, P., Parr, A., Polli, J.E., Mehta, M., Shah, V.P., Tajiri, T., Dressman, J.
Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Moxifloxacin Hydrochloride (2020) Journal of pharmaceutical sciences, 109 (9), 2654–2675. DOI: 10.1016/j.xphs.2020.06.007

Cinque, L., Leonibus, C. de, Iavazzo, M., Krahmer, N., Intartaglia, D., Salierno, F.G., Cegli, R. de, Di Malta, C., Svelto, M., Lanzara, C., Maddaluno, M., Wanderlingh, L.G., Huebner, A.K., Cesana, M., Bonn, F., Polishchuk, E., Hübner, C.A., Conte, I., Dikic, I., Mann, M., Ballabio, A., Sacco, F., Grumati, P., Settembre, C.
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B (2020) The EMBO journal, 39 (17), e105696. DOI: 10.15252/embj.2020105696

Cohnen, J., Kornstädt, L., Hahnefeld, L., Ferreiros, N., Pierre, S., Koehl, U., Deller, T., Geisslinger, G., Scholich, K.
Tumors Provoke Inflammation and Perineural Microlesions at Adjacent Peripheral Nerves (2020) Cells, 9 (2). DOI: 10.3390/cells9020320

Corman, V.M., Rabenau, H.F., Adams, O., Oberle, D., Funk, M.B., Keller-Stanislawski, B., Timm, J., Drosten, C., Ciesek, S.
SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission (2020) Transfusion, 60 (6), 1119–1122. DOI: 10.1111/trf.15841

Cruz-Aguilar, R., Carney, J., Mondaini, V., Vehreschild, M.J.G.T., Griskaitis, M., Salmanton-García, J., Böll, B., Kochanek, M., Seifert, H., Biehl, L.M., Farowski, F.
A quality improvement study on the reduction of central venous catheter-associated bloodstream infections by use of self-disinfecting venous access caps (STERILE) (2020) American journal of infection control . DOI: 10.1016/j.ajic.2020.09.002

D - F

Dauth, S., Rakov, H., Sîrbulescu, R.F., Ilieş, I., Weber, J., Batbajar Dugershaw, B., Braun, D., Rehders, M., Wirth, E.K., Führer, D., Schweizer, U., Brix, K.
Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland (2020) Cellular and molecular neurobiology, 40 (5), 695–710. DOI: 10.1007/s10571-019-00765-6

Davies, K., Lawrence, J., Berry, C., Davis, G., Yu, H., Cai, B., Gonzalez, E., Prantner, I., Kurcz, A., Macovei, I., Pituch, H., Nováková, E., Nyč, O., Gärtner, B., Berger, F.K., Oleastro, M., Cornely, O.A., Vehreschild, M.J.G.T., Pedneault, L., Wilcox, M.
Risk Factors for Primary Clostridium difficile Infection; Results From the Observational Study of Risk Factors for Clostridium difficile Infection in Hospitalized Patients With Infective Diarrhea (ORCHID) (2020) Frontiers in public health, 8, 293. DOI: 10.3389/fpubh.2020.00293

de Los Reyes Jiménez, Marta, Lechner, A., Alessandrini, F., Bohnacker, S., Schindela, S., Trompette, A., Haimerl, P., Thomas, D., Henkel, F., Mourão, A., Geerlof, A., Da Costa, C.P., Chaker, A.M., Brüne, B., Nüsing, R., Jakobsson, P.-J., Nockher, W.A., Feige, M.J., Haslbeck, M., Ohnmacht, C., Marsland, B.J., Voehringer, D., Harris, N.L., Schmidt-Weber, C.B., Esser-von Bieren, J.
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products (2020) Science translational medicine, 12 (540). DOI: 10.1126/scitranslmed.aay0605

Demir, M., Lang, S., Martin, A., Farowski, F., Wisplinghoff, H., Vehreschild, M.J.G.T., Krawczyk, M., Nowag, A., Scholz, C.J., Kretzschmar, A., Roderburg, C., Lammert, F., Goeser, T., Kasper, P., Steffen, H.-M.
Phenotyping non-alcoholic fatty liver disease by the gut microbiota: Ready for prime time? (2020) Journal of gastroenterology and hepatology, 35 (11), 1969–1977. DOI: 10.1111/jgh.15071

Duriez, M., Jacquet, A., Hoet, L., Roche, S., Bock, M.-D., Rocher, C., Haussy, G., Vigé, X., Bocskei, Z., Slavnic, T., Martin, V., Guillemot, J.-C., Didier, M., Kannt, A., Orsini, C., Mikol, V., Le Fèvre, A.-C.
A 3D Human Liver Model of Nonalcoholic Steatohepatitis (2020) Journal of clinical and translational hepatology, 8 (4), 359–370. DOI: 10.14218/JCTH.2020.00015

Ebert, R., Cumbana, R., Lehmann, C., Kutzner, L., Toewe, A., Ferreirós, N., Parnham, M.J., Schebb, N.H., Steinhilber, D., Kahnt, A.S.
Long-term stimulation of toll-like receptor-2 and -4 upregulates 5-LO and 15-LO-2 expression thereby inducing a lipid mediator shift in human monocyte-derived macrophages (2020) Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865 (9), 158702. DOI: 10.1016/j.bbalip.2020.158702

Eis-Hübinger, A.M., Hönemann, M., Wenzel, J.J., Berger, A., Widera, M., Schmidt, B., Aldabbagh, S., Marx, B., Streeck, H., Ciesek, S., Liebert, U.G., Huzly, D., Hengel, H., Panning, M.
Ad hoc laboratory-based surveillance of SARS-CoV-2 by real-time RT-PCR using minipools of RNA prepared from routine respiratory samples (2020) Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 127, 104381. DOI: 10.1016/j.jcv.2020.104381

Ellinger, B., Pohlmann, D., Woens, J., Jäkel, F.M., Reinshagen, J., Stocking, C., Prassolov, V.S., Fehse, B., Riecken, K.
A High-Throughput HIV-1 Drug Screening Platform, Based on Lentiviral Vectors and Compatible with Biosafety Level-1 (2020) Viruses, 12 (5). DOI: 10.3390/v12050580

Emmerich, A.C., Wellstein, J., Ossipova, E., Baumann, I., Lengqvist, J., Kultima, K., Jakobsson, P.-J., Steinhilber, D., Saul, M.J.
Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells (2020) Frontiers in pharmacology, 11, 196. DOI: 10.3389/fphar.2020.00196

Fiolka, T., van den Abeele, J., Augustijns, P., Arora, S., Dressman, J.
Biorelevant Two-Stage In Vitro Testing for rDCS Classification and in PBPK Modeling-Case Example Ritonavir (2020) Journal of pharmaceutical sciences, 109 (8), 2512–2526. DOI: 10.1016/j.xphs.2020.04.023

Frey, S., Sticht, H., Wilsmann-Theis, D., Gerschütz, A., Wolf, K., Löhr, S., Haskamp, S., Frey, B., Hahn, M., Ekici, A.B., Uebe, S., Thiel, C., Reis, A., Burkhardt, H., Behrens, F., Köhm, M., Rech, J., Schett, G., Assmann, G., Kingo, K., Kõks, S., Mössner, R., Prinz, J.C., Oji, V., Schulz, P., Muñoz, L.E., Kremer, A.E., Wenzel, J., Hüffmeier, U.
Rare Loss-of-Function Mutation in SERPINA3 in Generalized Pustular Psoriasis (2020) The Journal of investigative dermatology, 140 (7), 1451-1455.e13. DOI: 10.1016/j.jid.2019.11.024

Fuhrmann, D.C., Mondorf, A., Beifuß, J., Jung, M., Brüne, B.
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis (2020) Redox biology, 36, 101670. DOI: 10.1016/j.redox.2020.101670

G - I

Gellrich, L., Heitel, P., Heering, J., Kilu, W., Pollinger, J., Goebel, T., Kahnt, A., Arifi, S., Pogoda, W., Paulke, A., Steinhilber, D., Proschak, E., Wurglics, M., Schubert-Zsilavecz, M., Chaikuad, A., Knapp, S., Bischoff, I., Fürst, R., Merk, D.
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ (2020) Journal of medicinal chemistry, 63 (13), 6727–6740. DOI: 10.1021/acs.jmedchem.9b02150

Gerstein, H.C., Paré, G., McQueen, M.J., Lee, S.F., Bangdiwala, S.I., Kannt, A., Hess, S.
Novel Biomarkers for Change in Renal Function in People With Dysglycemia (2020) Diabetes care, 43 (2), 433–439. DOI: 10.2337/dc19-1604

Gross, T., Wack, G., Syhr, K.M.J., Tolmachova, T., Seabra, M.C., Geisslinger, G., Niederberger, E., Schmidtko, A., Kallenborn-Gerhardt, W.
Rab27a Contributes to the Processing of Inflammatory Pain in Mice (2020) Cells, 9 (6). DOI: 10.3390/cells9061488

Gunne, S., Heinicke, U., Parnham, M.J., Laux, V., Zacharowski, K., Knethen, A. von
Nrf2-A Molecular Target for Sepsis Patients in Critical Care (2020) Biomolecules, 10 (12). DOI: 10.3390/biom10121688

Hagenow, J., Hagenow, S., Grau, K., Khanfar, M., Hefke, L., Proschak, E., Stark, H.
Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs (2020) Drug design, development and therapy, 14, 371–393. DOI: 10.2147/DDDT.S236586

Hahnefeld, L., Gruber, L., Schömel, N., Fischer, C., Mattjus, P., Gurke, R., Beretta, M., Ferreirós, N., Geisslinger, G., Wegner, M.-S.
Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells (2020) The international journal of biochemistry & cell biology, 127, 105834. DOI: 10.1016/j.biocel.2020.105834

Hahnefeld, L., Gurke, R., Thomas, D., Schreiber, Y., Schäfer, S.M.G., Trautmann, S., Snodgrass, I.F., Kratz, D., Geisslinger, G., Ferreirós, N.
Implementation of lipidomics in clinical routine: Can fluoride/citrate blood sampling tubes improve preanalytical stability? (2020) Talanta, 209, 120593. DOI: 10.1016/j.talanta.2019.120593

Han, Y., Huard, A., Mora, J., Da Silva, P., Brüne, B., Weigert, A.
IL-36 family cytokines in protective versus destructive inflammation (2020) Cellular signalling, 75, 109773. DOI: 10.1016/j.cellsig.2020.109773

Hanke, T., Cheung, S.-Y., Kilu, W., Heering, J., Ni, X., Planz, V., Schierle, S., Faudone, G., Friedrich, M., Wanior, M., Werz, O., Windbergs, M., Proschak, E., Schubert-Zsilavecz, M., Chaikuad, A., Knapp, S., Merk, D.
A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode (2020) Journal of medicinal chemistry, 63 (9), 4555–4561. DOI: 10.1021/acs.jmedchem.9b01786

Harberts, J., Haferkamp, U., Haugg, S., Fendler, C., Lam, D., Zierold, R., Pless, O., Blick, R.H.
Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications (2020) Biomaterials science, 8 (9), 2434–2446. DOI: 10.1039/d0bm00182a

Hausmann, J., Kubesch, A., Goettlich, C.M., Rey, J., Wächtershäuser, A., Bojunga, J., Blumenstein, I.
Quality of life of patients with head and neck cancer after prophylactic percutaneous-gastrostomy (2020) European journal of clinical nutrition, 74 (4), 565–572. DOI: 10.1038/s41430-019-0499-5

Hefke, L., Hiesinger, K., Zhu, W.F., Kramer, J.S., Proschak, E.
Computer-Aided Fragment Growing Strategies to Design Dual Inhibitors of Soluble Epoxide Hydrolase and LTA4 Hydrolase (2020) ACS medicinal chemistry letters, 11 (6), 1244–1249. DOI: 10.1021/acsmedchemlett.0c00102

Heinen, S., Schulze, N., Franke, B., Klein, F., Lehmann, C., Vehreschild, M.J.G.T., Gloistein, C., Stecher, M., Vehreschild, J.J.
HEnRY: a DZIF LIMS tool for the collection and documentation of biomaterials in multicentre studies (2020) BMC bioinformatics, 21 (1), 290. DOI: 10.1186/s12859-020-03596-1

Heinicke, U., Adam, E., Sonntagbauer, M., Knethen, A. von, Zacharowski, K., Neb, H.
Angiotensin II treatment in COVID-19 patients: more risk than benefit? A single-center experience (2020) Critical care (London, England), 24 (1), 409. DOI: 10.1186/s13054-020-03143-7

Hernandez-Olmos, V., Heering, J., Planz, V., Liu, T., Kaps, A., Rajkumar, R., Gramzow, M., Kaiser, A., Schubert-Zsilavecz, M., Parnham, M.J., Windbergs, M., Steinhilber, D., Proschak, E.
First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters (2020) Journal of medicinal chemistry, 63 (20), 11548–11572. DOI: 10.1021/acs.jmedchem.0c00588

Hiesinger, K., Kramer, J.S., Beyer, S., Eckes, T., Brunst, S., Flauaus, C., Wittmann, S.K., Weizel, L., Kaiser, A., Kretschmer, S.B.M., George, S., Angioni, C., Heering, J., Geisslinger, G., Schubert-Zsilavecz, M., Schmidtko, A., Pogoryelov, D., Pfeilschifter, J., Hofmann, B., Steinhilber, D., Schwalm, S., Proschak, E.
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase (2020) Journal of medicinal chemistry, 63 (20), 11498–11521. DOI: 10.1021/acs.jmedchem.0c00561

Hinnah, K., Willems, S., Morstein, J., Heering, J., Hartrampf, F.W.W., Broichhagen, J., Leippe, P., Merk, D., Trauner, D.
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) (2020) Journal of medicinal chemistry, 63 (19), 10908–10920. DOI: 10.1021/acs.jmedchem.0c00654

Hoehl, S., Berger, A., Ciesek, S., Rabenau, H.F.
Thirty years of CMV seroprevalence-a longitudinal analysis in a German university hospital (2020) European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 39 (6), 1095–1102. DOI: 10.1007/s10096-020-03814-x

Hoehl, S., Karaca, O., Kohmer, N., Westhaus, S., Graf, J., Goetsch, U., Ciesek, S.
Assessment of SARS-CoV-2 Transmission on an International Flight and Among a Tourist Group (2020) JAMA network open, 3 (8), e2018044. DOI: 10.1001/jamanetworkopen.2020.18044

Hoehl, S., Rabenau, H., Berger, A., Kortenbusch, M., Cinatl, J., Bojkova, D., Behrens, P., Böddinghaus, B., Götsch, U., Naujoks, F., Neumann, P., Schork, J., Tiarks-Jungk, P., Walczok, A., Eickmann, M., Vehreschild, Maria J G T, Kann, G., Wolf, T., Gottschalk, R., Ciesek, S.
Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China (2020) The New England journal of medicine, 382 (13), 1278–1280. DOI: 10.1056/NEJMc2001899

Hofsäss, M.A., Dressman, J.
Evaluation of Differences in Dosage Form Performance of Generics Using BCS-Based Biowaiver Specifications and Biopharmaceutical Modeling-Case Examples Amoxicillin and Doxycycline (2020) Journal of pharmaceutical sciences, 109 (8), 2437–2453. DOI: 10.1016/j.xphs.2020.04.011

Hofsäss, M.A., Dressman, J.
Suitability of the z-Factor for Dissolution Simulation of Solid Oral Dosage Forms: Potential Pitfalls and Refinements (2020) Journal of pharmaceutical sciences, 109 (9), 2735–2745. DOI: 10.1016/j.xphs.2020.05.019

Hotter, G., Mastora, C., Jung, M., Brüne, B., Carbonell, T., Josa, C., Pérez-Calvo, J.I., Cruzado, J.M., Guiteras, R., Sola, A.
The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation (2020) Scientific reports, 10 (1), 15302. DOI: 10.1038/s41598-020-72342-7

Huber, J., Obata, M., Gruber, J., Akutsu, M., Löhr, F., Rogova, N., Güntert, P., Dikic, I., Kirkin, V., Komatsu, M., Dötsch, V., Rogov, V.V.
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Hughes, M., Heal, C., Siegert, E., Hachulla, E., Airó, P., Riccardi, A., Distler, O., Matucci-Cerinic, M.
Significant weight loss in systemic sclerosis: a study from the EULAR Scleroderma Trials and Research (EUSTAR) database (2020) Annals of the rheumatic diseases, 79 (8), 1123–1125. DOI: 10.1136/annrheumdis-2020-217035

Ingelfinger, R., Henke, M., Roser, L., Ulshöfer, T., Calchera, A., Singh, G., Parnham, M.J., Geisslinger, G., Fürst, R., Schmitt, I., Schiffmann, S.
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Janssen, M., Schäkel, U., Djuka Fokou, C., Krisam, J., Stermann, J., Kriegsmann, K., Haberbosch, I., Novotny, J.P., Weber, S., Vehreschild, M., Bornhäuser, M., Bullinger, L., Schmitt, M., Liebregts, T., Dreger, P., Lorenz, H.-M., Plaszczyca, A., Bartenschlager, R., Müller, B., Kräusslich, H.-G., Halama, N., Jäger, D., Schlenk, R.F., Leo, A., Meuer, S., Weigand, M.A., Motsch, J., Merle, U., Denkinger, C.M., Müller-Tidow, C.
A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial (2020) Trials, 21 (1), 828. DOI: 10.1186/s13063-020-04735-y

Kallenborn-Gerhardt, W., Metzner, K., Lu, R., Petersen, J., Kuth, M.S., Heine, S., Drees, O., Paul, M., Becirovic, E., Kennel, L., Flauaus, C., Gross, T., Wack, G., Hohmann, S.W., Nemirovski, D., Del Turco, D., Biel, M., Geisslinger, G., Michalakis, S., Schmidtko, A.
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Kannt, A., Madsen, A.N., Kammermeier, C., Elvert, R., Klöckener, T., Bossart, M., Haack, T., Evers, A., Lorenz, K., Hennerici, W., Rocher, C., Böcskei, Z., Guillemot, J.-C., Mikol, V., Pattou, F., Staels, B., Wagner, M.
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Karathanasis, C., Medler, J., Fricke, F., Smith, S., Malkusch, S., Widera, D., Fulda, S., Wajant, H., van Wijk, Sjoerd J L, Dikic, I., Heilemann, M.
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Kedor, C., Listing, J., Zernicke, J., Weiß, A., Behrens, F., Blank, N., Henes, J.C., Kekow, J., Rubbert-Roth, A., Schulze-Koops, H., Seipelt, E., Specker, C., Feist, E.
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Keller, J.J., Ooijevaar, R.E., Hvas, C.L., Terveer, E.M., Lieberknecht, S.C., Högenauer, C., Arkkila, P., Sokol, H., Gridnyev, O., Mégraud, F., Kump, P.K., Nakov, R., Goldenberg, S.D., Satokari, R., Tkatch, S., Sanguinetti, M., Cammarota, G., Dorofeev, A., Gubska, O., Ianiro, G., Mattila, E., Arasaradnam, R.P., Sarin, S.K., Sood, A., Putignani, L., Alric, L., Baunwall, S.M., Kupcinskas, J., Link, A., Goorhuis, A.G., Verspaget, H.W., Ponsioen, C., Hold, G.L., Tilg, H., Kassam, Z., Kuijper, E.J., Gasbarrini, A., Mulder, C.J., Williams, H.R., Vehreschild, M.J.
A standardised model for stool banking for faecal microbiota transplantation: a consensus report from a multidisciplinary UEG working group (2020) United European gastroenterology journal, 2050640620967898. DOI: 10.1177/2050640620967898

Keller, J.J., Vehreschild, M.J., Hvas, C.L., Jørgensen, S.M., Kupcinskas, J., Link, A., Mulder, C.J., Goldenberg, S.D., Arasaradnam, R., Sokol, H., Gasbarrini, A., Hoegenauer, C., Terveer, E.M., Kuijper, E.J., Arkkila, P.
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Keminer, O., Teigeler, M., Kohler, M., Wenzel, A., Arning, J., Kaßner, F., Windshügel, B., Eilebrecht, E.
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Kesavan, R., Frömel, T., Zukunft, S., Laban, H., Geyer, A., Naeem, Z., Heidler, J., Wittig, I., Elwakeel, E., Brüne, B., Weigert, A., Popp, R., Fleming, I.
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Kikuchi-Taura, A., Okinaka, Y., Takeuchi, Y., Ogawa, Y., Maeda, M., Kataoka, Y., Yasui, T., Kimura, T., Gul, S., Claussen, C., Boltze, J., Taguchi, A.
Bone Marrow Mononuclear Cells Activate Angiogenesis via Gap Junction-Mediated Cell-Cell Interaction (2020) Stroke, 51 (4), 1279–1289. DOI: 10.1161/STROKEAHA.119.028072

Kim, R.Q., Misra, M., Gonzalez, A., Tomašković, I., Shin, D., Schindelin, H., Filippov, D.V., Ovaa, H., Đikić, I., van der Heden van Noort, Gerbrand J
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Klann, K., Bojkova, D., Tascher, G., Ciesek, S., Münch, C., Cinatl, J.
Growth Factor Receptor Signaling Inhibition Prevents SARS-CoV-2 Replication (2020) Molecular cell, 80 (1), 164-174.e4. DOI: 10.1016/j.molcel.2020.08.006

Klatt-Schreiner, K., Valek, L., Kang, J.-S., Khlebtovsky, A., Trautmann, S., Hahnefeld, L., Schreiber, Y., Gurke, R., Thomas, D., Wilken-Schmitz, A., Wicker, S., Auburger, G., Geisslinger, G., Lötsch, J., Pfeilschifter, W., Djaldetti, R., Tegeder, I.
High Glucosylceramides and Low Anandamide Contribute to Sensory Loss and Pain in Parkinson's Disease (2020) Movement disorders : official journal of the Movement Disorder Society, 35 (10), 1822–1833. DOI: 10.1002/mds.28186

Klippenstein, V., Ciesek, S., Riemann, J.F.
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Klitsch, A., Evdokimov, D., Frank, J., Thomas, D., Saffer, N., Meyer Zu Altenschildesche, C., Sisignano, M., Kampik, D., Malik, R.A., Sommer, C., Üçeyler, N.
Reduced association between dendritic cells and corneal sub-basal nerve fibers in patients with fibromyalgia syndrome (2020) Journal of the peripheral nervous system : JPNS, 25 (1), 9–18. DOI: 10.1111/jns.12360

Klöß, S., Dehmel, S., Braun, A., Parnham, M.J., Köhl, U., Schiffmann, S.
From Cancer to Immune-Mediated Diseases and Tolerance Induction: Lessons Learned From Immune Oncology and Classical Anti-cancer Treatment (2020) Frontiers in immunology, 11, 1423. DOI: 10.3389/fimmu.2020.01423

Klumpp, L., Dressman, J.
Physiologically based pharmacokinetic model outputs depend on dissolution data and their input: Case examples glibenclamide and dipyridamole (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 151, 105380. DOI: 10.1016/j.ejps.2020.105380

Klumpp, L., Leigh, M., Dressman, J.
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Knethen, A. von, Heinicke, U., Weigert, A., Zacharowski, K., Brüne, B.
Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells (2020) International journal of molecular sciences, 21 (7). DOI: 10.3390/ijms21072356

Koehm, M., McIntosh, M.J., Hofmann, M.W., Abraham, V., Gabay, C., Choy, E.H., Kavanaugh, A., Burkhardt, H., Behrens, F.
Individual therapeutic DAS28-d(crit) responses differentiate between effectiveness of rheumatoid arthritis therapies and reflect patient-reported outcomes: retrospective analysis of DAS28 responses in comparative tocilizumab studies (2020) Rheumatology international, 40 (5), 747–755. DOI: 10.1007/s00296-020-04514-7

Köhm, M., Burkhardt, H., Behrens, F.
Treatment strategies in psoriatic arthritis (2020) Deutsche medizinische Wochenschrift (1946), 145 (11), 773–780. DOI: 10.1055/a-0964-0231

Köhm, M., Zerweck, L., Ngyuen, P.-H., Burkhardt, H., Behrens, F.
Innovative Imaging Technique for Visualization of Vascularization and Established Methods for Detection of Musculoskeletal Inflammation in Psoriasis Patients (2020) Frontiers in medicine, 7, 468. DOI: 10.3389/fmed.2020.00468

Kohmer, N., Westhaus, S., Rühl, C., Ciesek, S., Rabenau, H.F.
Brief clinical evaluation of six high-throughput SARS-CoV-2 IgG antibody assays (2020) Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 129, 104480. DOI: 10.1016/j.jcv.2020.104480

Kohmer, N., Westhaus, S., Rühl, C., Ciesek, S., Rabenau, H.F.
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Kreer, C., Zehner, M., Weber, T., Ercanoglu, M.S., Gieselmann, L., Rohde, C., Halwe, S., Korenkov, M., Schommers, P., Vanshylla, K., Di Cristanziano, V., Janicki, H., Brinker, R., Ashurov, A., Krähling, V., Kupke, A., Cohen-Dvashi, H., Koch, M., Eckert, J.M., Lederer, S., Pfeifer, N., Wolf, T., Vehreschild, M.J.G.T., Wendtner, C., Diskin, R., Gruell, H., Becker, S., Klein, F.
Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients (2020) Cell, 182 (6), 1663–1673. DOI: 10.1016/j.cell.2020.08.046

Kreer, C., Zehner, M., Weber, T., Ercanoglu, M.S., Gieselmann, L., Rohde, C., Halwe, S., Korenkov, M., Schommers, P., Vanshylla, K., Di Cristanziano, V., Janicki, H., Brinker, R., Ashurov, A., Krähling, V., Kupke, A., Cohen-Dvashi, H., Koch, M., Eckert, J.M., Lederer, S., Pfeifer, N., Wolf, T., Vehreschild, Maria J G T, Wendtner, C., Diskin, R., Gruell, H., Becker, S., Klein, F. Longitudinal Isolation of Potent Near-Germline SARS-CoV-2-Neutralizing Antibodies from COVID-19 Patients (2020) Cell, 182 (4), 843-854.e12. DOI: 10.1016/j.cell.2020.06.044

Kriesel, F., Stegmann, L., Ciesek, S., Kaderali, L., Baldauf, H.-M.
Efficient inactivation of pseudotyped HIV-based lentiviral vectors and infectious HIV (2020) Journal of virological methods, 276, 113768. DOI: 10.1016/j.jviromet.2019.113768

Kubesch, A., Boulahrout, P., Filmann, N., Blumenstein, I., Hausmann, J.
Real-world data about emotional stress, disability and need for social care in a German IBD patient cohort (2020) PloS one, 15 (1), e0227309. DOI: 10.1371/journal.pone.0227309

Kuijper, E.J., Vehreschild, Maria J G T
Clinical microbiota and infection (2020) Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 26 (11), 1447. DOI: 10.1016/j.cmi.2020.09.029

Lang, S., Farowski, F., Martin, A., Wisplinghoff, H., Vehreschild, M.J.G.T., Krawczyk, M., Nowag, A., Kretzschmar, A., Scholz, C., Kasper, P., Roderburg, C., Lammert, F., Goeser, T., Steffen, H.-M., Demir, M.
Prediction of advanced fibrosis in non-alcoholic fatty liver disease using gut microbiota-based approaches compared with simple non-invasive tools (2020) Scientific reports, 10 (1), 9385. DOI: 10.1038/s41598-020-66241-0

Lang, S., Martin, A., Farowski, F., Wisplinghoff, H., Vehreschild, M.J.G.T., Liu, J., Krawczyk, M., Nowag, A., Kretzschmar, A., Herweg, J., Schnabl, B., Tu, X.M., Lammert, F., Goeser, T., Tacke, F., Heinzer, K., Kasper, P., Steffen, H.-M., Demir, M.
High Protein Intake Is Associated With Histological Disease Activity in Patients With NAFLD (2020) Hepatology communications, 4 (5), 681–695. DOI: 10.1002/hep4.1509

Lerch, F., Ultsch, A., Lötsch, J.
Distribution Optimization: An evolutionary algorithm to separate Gaussian mixtures (2020) Scientific reports, 10 (1), 648. DOI: 10.1038/s41598-020-57432-w

Lin, J., Hu, J., Schlotterer, A., Wang, J., Kolibabka, M., Awwad, K., Dietrich, N., Breitschopf, K., Wohlfart, P., Kannt, A., Lorenz, K., Feng, Y., Popp, R., Hoffmann, S., Fleming, I., Hammes, H.P.
Protective effect of Soluble Epoxide Hydrolase Inhibition in Retinal Vasculopathy associated with Polycystic Kidney Disease (2020) Theranostics, 10 (17), 7857–7871. DOI: 10.7150/thno.43154

Linciano, P., Cullia, G., Borsari, C., Santucci, M., Ferrari, S., Witt, G., Gul, S., Kuzikov, M., Ellinger, B., Santarém, N., Da Cordeiro Silva, A., Conti, P., Bolognesi, M.L., Roberti, M., Prati, F., Bartoccini, F., Retini, M., Piersanti, G., Cavalli, A., Goldoni, L., Bertozzi, S.M., Bertozzi, F., Brambilla, E., Rizzo, V., Piomelli, D., Pinto, A., Bandiera, T., Costi, M.P.
Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign (2020) European journal of medicinal chemistry, 189, 112047. DOI: 10.1016/j.ejmech.2020.112047

Litou, C., Psachoulias, D., Vertzoni, M., Dressman, J., Reppas, C.
Measuring pH and Buffer Capacity in Fluids Aspirated from the Fasted Upper Gastrointestinal Tract of Healthy Adults (2020) Pharmaceutical research, 37 (3), 42. DOI: 10.1007/s11095-019-2731-3

Litou, C., Turner, D.B., Holmstock, N., Ceulemans, J., Box, K.J., Kostewicz, E., Kuentz, M., Holm, R., Dressman, J.
Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 149, 105297. DOI: 10.1016/j.ejps.2020.105297

Loisios-Konstantinidis, I., Cristofoletti, R., Fotaki, N., Turner, D.B., Dressman, J.
Establishing virtual bioequivalence and clinically relevant specifications using in vitro biorelevant dissolution testing and physiologically-based population pharmacokinetic modeling. case example: Naproxen (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 143, 105170. DOI: 10.1016/j.ejps.2019.105170

Loisios-Konstantinidis, I., Cristofoletti, R., Jamei, M., Turner, D., Dressman, J.
Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Predict the Impact of CYP2C9 Genetic Polymorphisms, Co-Medication and Formulation on the Pharmacokinetics and Pharmacodynamics of Flurbiprofen (2020) Pharmaceutics, 12 (11). DOI: 10.3390/pharmaceutics12111049

López, M., Heitmeier, S., Laux, V., Nowak, G.
The dual FXa/thrombin inhibitor SATI prevents fibrin and platelet deposition in hypercoagulant rats (2020) Thrombosis research, 193, 15–21. DOI: 10.1016/j.thromres.2020.05.016

Lötsch, J., Hummel, T.
A data science-based analysis of seasonal patterns in outpatient presentations due to olfactory dysfunction (2020) Rhinology, 58 (2), 151–157. DOI: 10.4193/Rhin19.099.

Lötsch, J., Alfredsson, L., Lampa, J.
Machine-learning-based knowledge discovery in rheumatoid arthritis-related registry data to identify predictors of persistent pain (2020) Pain, 161 (1), 114–126. DOI: 10.1097/j.pain.0000000000001693

Lötsch, J., Geisslinger, G., Walter, C.
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Lötsch, J., Haehner, A., Hummel, T.
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Lötsch, J., Kringel, D., Geisslinger, G., Oertel, B.G., Resch, E., Malkusch, S.
Machine-Learned Association of Next-Generation Sequencing-Derived Variants in Thermosensitive Ion Channels Genes with Human Thermal Pain Sensitivity Phenotypes (2020) International journal of molecular sciences, 21 (12). DOI: 10.3390/ijms21124367

Lötsch, J., Malkusch, S.
Interpretation of cluster structures in pain-related phenotype data using explainable artificial intelligence (XAI) (2020) European journal of pain (London, England) . DOI: 10.1002/ejp.1683

Lötsch, J., Oertel, B.G., Felden, L., Nöth, U., Deichmann, R., Hummel, T., Walter, C.
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Lötsch, J., Ultsch, A., Kalso, E.
Data-science-based subgroup analysis of persistent pain during 3 years after breast cancer surgery: A prospective cohort study (2020) European journal of anaesthesiology, 37 (3), 235–246. DOI: 10.1097/EJA.0000000000001116.

Lötsch, J., Walter, C., Zunftmeister, M., Zinn, S., Wolters, M., Ferreiros, N., Rossmanith, T., Oertel, B.G., Geisslinger, G.
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Luo, C., Pook, E., Wang, F., Archacki, S.R., Tang, B., Zhang, W., Hu, J.-S., Yang, J., Leineweber, K., Bechem, M., Huang, W., Song, Y., Cheung, S.-H., Laux, V., Ke, T., Ren, X., Tu, X., Chen, Q., Wang, Q.K., Xu, C.
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Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms (2020) Cell chemical biology, 27 (11), 1441-1451.e7. DOI: 10.1016/j.chembiol.2020.07.010

Marbach-Breitrück, E., Kutzner, L., Rothe, M., Gurke, R., Schreiber, Y., Reddanna, P., Schebb, N.-H., Stehling, S., Wieler, L.H., Heydeck, D., Kuhn, H.
Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme (2020) Antioxidants & redox signaling, 32 (1), 1–17. DOI: 10.1089/ars.2019.7751

McInnes, I.B., Behrens, F., Mease, P.J., Kavanaugh, A., Ritchlin, C., Nash, P., Masmitja, J.G., Goupille, P., Korotaeva, T., Gottlieb, A.B., Martin, R., Ding, K., Pellet, P., Mpofu, S., Pricop, L.
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Mease, P.J., Gladman, D.D., Ogdie, A., Coates, L.C., Behrens, F., Kavanaugh, A., McInnes, I., Queiro, R., Guerette, B., Brunori, M., Teng, L., Smolen, J.S.
Treatment-to-Target With Apremilast in Psoriatic Arthritis: The Probability of Achieving Targets and Comprehensive Control of Disease Manifestations (2020) Arthritis care & research, 72 (6), 814–821. DOI: 10.1002/acr.24134

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Meijer, I., Willems, S., Ni, X., Heering, J., Chaikuad, A., Merk, D.
Chemical Starting Matter for HNF4α Ligand Discovery and Chemogenomics (2020) International journal of molecular sciences, 21 (21). DOI: 10.3390/ijms21217895

Mertens, C., Kuchler, L., Sola, A., Guiteras, R., Grein, S., Brüne, B., Knethen, A. von, Jung, M. Macrophage-Derived Iron-Bound Lipocalin-2 Correlates with Renal Recovery Markers Following Sepsis-Induced Kidney Damage (2020) International journal of molecular sciences, 21 (20). DOI: 10.3390/ijms21207527

Meyer, S. de, Bojkova, D., Cinatl, J., van Damme, E., Buyck, C., van Loock, M., Woodfall, B., Ciesek, S.
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Mishra, A., Castañeda, T.R., Bader, E., Elshorst, B., Cummings, S., Scherer, P., Bangari, D.S., Loewe, C., Schreuder, H., Pöverlein, C., Helms, M., Jones, S., Zech, G., Licher, T., Wagner, M., Schudok, M., Hoop, M. de, Plowright, A.T., Atzrodt, J., Kannt, A., Laitinen, I., Derdau, V.
Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis (2020) Advanced science (Weinheim, Baden-Wurttemberg, Germany), 7 (24), 2002997. DOI: 10.1002/advs.202002997

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The Specific IKKε/TBK1 Inhibitor Amlexanox Suppresses Human Melanoma by the Inhibition of Autophagy, NF-κB and MAP Kinase Pathways (2020) International journal of molecular sciences, 21 (13). DOI: 10.3390/ijms21134721

Mostazo, M.G.C., Kurrle, N., Casado, M., Fuhrmann, D., Alshamleh, I., Häupl, B., Martín-Sanz, P., Brüne, B., Serve, H., Schwalbe, H., Schnütgen, F., Marin, S., Cascante, M.
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Muenchhoff, M., Mairhofer, H., Nitschko, H., Grzimek-Koschewa, N., Hoffmann, D., Berger, A., Rabenau, H., Widera, M., Ackermann, N., Konrad, R., Zange, S., Graf, A., Krebs, S., Blum, H., Sing, A., Liebl, B., Wölfel, R., Ciesek, S., Drosten, C., Protzer, U., Boehm, S., Keppler, O.T.
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Nieraad, H., Bruin, N. de, Arne, O., Hofmann, M.C.J., Schmidt, M., Saito, T., Saido, T.C., Gurke, R., Schmidt, D., Till, U., Parnham, M.J., Geisslinger, G.
Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease (2020) Nutrients, 12 (11). DOI: 10.3390/nu12113248

Olesch, C., Sirait-Fischer, E., Berkefeld, M., Fink, A.F., Susen, R.M., Ritter, B., Michels, B.E., Steinhilber, D., Greten, F.R., Savai, R., Takeda, K., Brüne, B., Weigert, A.
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Osthues, T., Zimmer, B., Rimola, V., Klann, K., Schilling, K., Mathoor, P., Angioni, C., Weigert, A., Geisslinger, G., Münch, C., Scholich, K., Sisignano, M.
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Panova-Noeva, M., Wagner, B., Nagler, M., Koeck, T., Cate, V. ten, Prochaska, J.H., Heitmeier, S., Meyer, I., Gerdes, C., Laux, V., Konstantinides, S., Spronk, H.M., Münzel, T., Lackner, K.J., Leineweber, K., Cate, H. ten, Wild, P.S.
Comprehensive platelet phenotyping supports the role of platelets in the pathogenesis of acute venous thromboembolism - results from clinical observation studies (2020) EBioMedicine, 60, 102978. DOI: 10.1016/j.ebiom.2020.102978

Paraiso, R.L.M., Rose, R.H., Fotaki, N., McAllister, M., Dressman, J.B.
The use of PBPK/PD to establish clinically relevant dissolution specifications for zolpidem immediate release tablets (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105534. DOI: 10.1016/j.ejps.2020.105534

Pentafragka, C., Vertzoni, M., Dressman, J., Symillides, M., Goumas, K., Reppas, C.
Characteristics of contents in the upper gastrointestinal lumen after a standard high-calorie high-fat meal and implications for the in vitro drug product performance testing conditions (2020) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105535. DOI: 10.1016/j.ejps.2020.105535

Peveling-Oberhag, J., Michael, F., Tal, A., Welsch, C., Vermehren, J., Farnik, H., Grammatikos, G., Lange, C., Walter, D., Blumenstein, I., Filmann, N., Herrmann, E., Albert, J., Zeuzem, S., Bojunga, J., Friedrich-Rust, M.
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Pflüger-Müller, B., Oo, J.A., Heering, J., Warwick, T., Proschak, E., Günther, S., Looso, M., Rezende, F., Fork, C., Geisslinger, G., Thomas, D., Gurke, R., Steinhilber, D., Schulz, M., Leisegang, M.S., Brandes, R.P.
The endocannabinoid anandamide has an anti-inflammatory effect on CCL2 expression in vascular smooth muscle cells (2020) Basic research in cardiology, 115 (3), 34. DOI: 10.1007/s00395-020-0793-3

Piesche, M., Roos, J., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Maucher, I.V., Awad, O., Matrone, C., Comerma Steffensen, S.G., Manolikakes, G., Heinicke, U., Zacharowski, K.D., Steinhilber, D., Maier, T.J.
The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer (2020) Frontiers in pharmacology, 11, 1297. DOI: 10.3389/fphar.2020.01297

Plöger, G.F., Quizon, P.M., Abrahamsson, B., Cristofoletti, R., Groot, D.W., Parr, A., Langguth, P., Polli, J.E., Shah, V.P., Tajiri, T., Mehta, M.U., Dressman, J.
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Cephalexin Monohydrate (2020) Journal of pharmaceutical sciences, 109 (6), 1846–1862. DOI: 10.1016/j.xphs.2020.03.025

Price, D.J., Nair, A., Becker-Baldus, J., Glaubitz, C., Kuentz, M., Dressman, J., Saal, C.
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Puntmann, V.O., Carerj, M.L., Wieters, I., Fahim, M., Arendt, C., Hoffmann, J., Shchendrygina, A., Escher, F., Vasa-Nicotera, M., Zeiher, A.M., Vehreschild, M., Nagel, E.
Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) (2020) JAMA cardiology, 5 (11), 1265–1273. DOI: 10.1001/jamacardio.2020.3557

Putyrski, M., Vakhrusheva, O., Bonn, F., Guntur, S., Vorobyov, A., Brandts, C., Dikic, I., Ernst, A.
Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine (2020) Frontiers in cell and developmental biology, 8, 208. DOI: 10.3389/fcell.2020.00208

Queck, A., Fink, A.F., Sirait-Fischer, E., Rüschenbaum, S., Thomas, D., Snodgrass, R.G., Geisslinger, G., Baba, H.A., Trebicka, J., Zeuzem, S., Weigert, A., Lange, C.M., Brüne, B.
Alox12/15 Deficiency Exacerbates, While Lipoxin A(4) Ameliorates Hepatic Inflammation in Murine Alcoholic Hepatitis (2020) Frontiers in immunology, 11, 1447. DOI: 10.3389/fimmu.2020.01447

Rehwald, C., Schnetz, M., Urbschat, A., Mertens, C., Meier, J.K., Bauer, R., Baer, P., Winslow, S., Roos, F.C., Zwicker, K., Huard, A., Weigert, A., Brüne, B., Jung, M.
The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma (2020) British journal of cancer, 122 (3), 421–433. DOI: 10.1038/s41416-019-0655-7

Reppas, C., Vrettos, N.-N., Dressman, J., Andreas, C.J., Miyaji, Y., Brown, J., Etherson, K., Hanley, S., Karkossa, F., Karlsson, E., Klein, S., Maier, G.-M., McAllister, M., Mistry, N., Rosenblatt, K., Schäfer, K.J., Smith, K.L., Tomaszewska, I., Williams, J., Winge, F., Vertzoni, M.
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Rimola, V., Hahnefeld, L., Zhao, J., Jiang, C., Angioni, C., Schreiber, Y., Osthues, T., Pierre, S., Geisslinger, G., Ji, R.-R., Scholich, K., Sisignano, M.
Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain (2020) The Journal of neuroscience : the official journal of the Society for Neuroscience, 40 (49), 9519–9532. DOI: 10.1523/JNEUROSCI.1223-20.2020

Rohde, A.M., Zweigner, J., Wiese-Posselt, M., Schwab, F., Behnke, M., Kola, A., Schröder, W., Peter, S., Tacconelli, E., Wille, T., Feihl, S., Querbach, C., Gebhardt, F., Gölz, H., Schneider, C., Mischnik, A., Vehreschild, M.J.G.T., Seifert, H., Kern, W.V., Gastmeier, P., Hamprecht, A.
Prevalence of third-generation cephalosporin-resistant Enterobacterales colonization on hospital admission and ESBL genotype-specific risk factors: a cross-sectional study in six German university hospitals (2020) The Journal of antimicrobial chemotherapy, 75 (6), 1631–1638. DOI: 10.1093/jac/dkaa052

Ruhnke, M., Cornely, O.A., Schmidt-Hieber, M., Alakel, N., Boell, B., Buchheidt, D., Christopeit, M., Hasenkamp, J., Heinz, W.J., Hentrich, M., Karthaus, M., Koldehoff, M., Maschmeyer, G., Panse, J., Penack, O., Schleicher, J., Teschner, D., Ullmann, A.J., Vehreschild, M., Lilienfeld-Toal, M. von, Weissinger, F., Schwartz, S.
Treatment of invasive fungal diseases in cancer patients-Revised 2019 Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) (2020) Mycoses, 63 (7), 653–682. DOI: 10.1111/myc.13082

Runfola, M., Sestito, S., Bellusci, L., La Pietra, V., D'Amore, V.M., Kowalik, M.A., Chiellini, G., Gul, S., Perra, A., Columbano, A., Marinelli, L., Novellino, E., Rapposelli, S.
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis (2020) European journal of medicinal chemistry, 188, 112006. DOI: 10.1016/j.ejmech.2019.112006

Runfola, M., Sestito, S., Gul, S., Chiellini, G., Rapposelli, S.
Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics (2020) Data in brief, 29, 105206. DOI: 10.1016/j.dib.2020.105206

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Salado, I.G., Singh, A.K., Moreno-Cinos, C., Sakaine, G., Siderius, M., van der Veken, P., an Matheeussen, van der Meer, T., Sadek, P., Gul, S., Maes, L., Sterk, G.-J., Leurs, R., Brown, D., Augustyns, K.
Lead Optimization of Phthalazinone Phosphodiesterase Inhibitors as Novel Antitrypanosomal Compounds (2020) Journal of medicinal chemistry, 63 (7), 3485–3507. DOI: 10.1021/acs.jmedchem.9b00985

Salazar, Y., Zheng, X., Brunn, D., Raifer, H., Picard, F., Zhang, Y., Winter, H., Guenther, S., Weigert, A., Weigmann, B., Dumoutier, L., Renauld, J.-C., Waisman, A., Schmall, A., Tufman, A., Fink, L., Brüne, B., Bopp, T., Grimminger, F., Seeger, W., Pullamsetti, S.S., Huber, M., Savai, R.
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Sargsyan, A., Kodamullil, A.T., Baksi, S., Darms, J., Madan, S., Gebel, S., Keminer, O., Jose, G.M., Balabin, H., DeLong, L.N., Kohler, M., Jacobs, M., Hofmann-Apitius, M.
The COVID-19 Ontology (2020) Bioinformatics (Oxford, England) . DOI: 10.1093/bioinformatics/btaa1057

Sarode, P., Zheng, X., Giotopoulou, G.A., Weigert, A., Kuenne, C., Günther, S., Friedrich, A., Gattenlöhner, S., Stiewe, T., Brüne, B., Grimminger, F., Stathopoulos, G.T., Pullamsetti, S.S., Seeger, W., Savai, R.
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Schäfer, R., Spohn, G., Bechtel, M., Bojkova, D., Baer, P.C., Kuçi, S., Seifried, E., Ciesek, S., Cinatl, J.
Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells (2020) Stem cell reports . DOI: 10.1016/j.stemcr.2020.09.003

Schäfer, S.M.G., Sendetski, M., Angioni, C., Nüsing, R., Geisslinger, G., Scholich, K., Sisignano, M.
The omega-3 lipid 17,18-EEQ sensitizes TRPV1 and TRPA1 in sensory neurons through the prostacyclin receptor (IP) (2020) Neuropharmacology, 166, 107952. DOI: 10.1016/j.neuropharm.2020.107952

Schalk, E., Vehreschild, M.J.G.T., Biehl, L.M.
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Schierle, S., Helmstädter, M., Schmidt, J., Hartmann, M., Horz, M., Kaiser, A., Weizel, L., Heitel, P., Proschak, A., Hernandez-Olmos, V., Proschak, E., Merk, D.
Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast (2020) ChemMedChem, 15 (1), 50–67. DOI: 10.1002/cmdc.201900576

Schlag, K., Steinhilber, D., Karas, M., Sorg, B.L.
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Schmalzing, M., Behrens, F., Schwaneck, E.C., Koehm, M., Greger, G., Gnann, H., Burkhardt, H., Tony, H.-P.
Does concomitant methotrexate confer clinical benefits in patients treated with prior biologic therapy? Analysis of data from a noninterventional study of rheumatoid arthritis patients initiating treatment with adalimumab (2020) Medicine, 99 (19), e20201. DOI: 10.1097/MD.0000000000020201

Schmidt, M., Hoehl, S., Berger, A., Zeichhardt, H., Hourfar, K., Ciesek, S., Seifried, E.
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Schmoll, D., Ziegler, N., Viollet, B., Foretz, M., Even, P.C., Azzout-Marniche, D., Nygaard Madsen, A., Illemann, M., Mandrup, K., Feigh, M., Czech, J., Glombik, H., Olsen, J.A., Hennerici, W., Steinmeyer, K., Elvert, R., Castañeda, T.R., Kannt, A.
Activation of Adenosine Monophosphate-Activated Protein Kinase Reduces the Onset of Diet-Induced Hepatocellular Carcinoma in Mice (2020) Hepatology communications, 4 (7), 1056–1072. DOI: 10.1002/hep4.1508

Schnetz, M., Meier, J.K., Rehwald, C., Mertens, C., Urbschat, A., Tomat, E., Akam, E.A., Baer, P., Roos, F.C., Brüne, B., Jung, M.
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Schnitzbauer, A.A., Kempf, V.A.J., Hack, D., Ciesek, S., Meier, S., Vehreschild, Maria J G T, Wicker, S., Kippke, U., Graf, J., Marzi, I.
SARS-CoV-2/COVID-19: systematic review of requirements for personal protective equipment in primary patient contact and organization of the operating area (2020) Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 91 (7), 576–585. DOI: 10.1007/s00104-020-01229-0

Scholz, A., Rappl, P., Böffinger, N., Mota, A.C., Brüne, B., Schmid, T.
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Scholz, M.S., Wingen, L.M., Brunst, S., Wittmann, S.K., Cardoso, I.L.A., Weizel, L., Proschak, E.
Soluble epoxide hydrolase inhibitors with carboranes as non-natural 3-D pharmacophores (2020) European journal of medicinal chemistry, 185, 111766. DOI: 10.1016/j.ejmech.2019.111766

Schömel, N., Geisslinger, G., Wegner, M.-S.
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Schömel, N., Gruber, L., Alexopoulos, S.J., Trautmann, S., Olzomer, E.M., Byrne, F.L., Hoehn, K.L., Gurke, R., Thomas, D., Ferreirós, N., Geisslinger, G., Wegner, M.-S.
UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells (2020) Scientific reports, 10 (1), 8182. DOI: 10.1038/s41598-020-65182-y

Schultheiß, C., Paschold, L., Simnica, D., Mohme, M., Willscher, E., Wenserski, L. von, Scholz, R., Wieters, I., Dahlke, C., Tolosa, E., Sedding, D.G., Ciesek, S., Addo, M., Binder, M.
Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease (2020) Immunity, 53 (2), 442-455.e4. DOI: 10.1016/j.immuni.2020.06.024

Schuster, C., Huard, A., Sirait-Fischer, E., Dillmann, C., Brüne, B., Weigert, A.
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Sehnert, B., Burkhardt, H., Dübel, S., Voll, R.E.
Cell-Type Targeted NF-kappaB Inhibition for the Treatment of Inflammatory Diseases (2020) Cells, 9 (7). DOI: 10.3390/cells9071627

Sezin, T., Ferreirós, N., Jennrich, M., Ochirbold, K., Seutter, M., Attah, C., Mousavi, S., Zillikens, D., Geisslinger, G., Sadik, C.D.
12/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation (2020) Journal of autoimmunity, 115, 102528. DOI: 10.1016/j.jaut.2020.102528

Sipilä, R., Kalso, E., Lötsch, J.
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Sirait-Fischer, E., Olesch, C., Fink, A.F., Berkefeld, M., Huard, A., Schmid, T., Takeda, K., Brüne, B., Weigert, A.
Immune Checkpoint Blockade Improves Chemotherapy in the PyMT Mammary Carcinoma Mouse Model (2020) Frontiers in oncology, 10, 1771. DOI: 10.3389/fonc.2020.01771

Sisignano, M., Steinhilber, D., Parnham, M.J., Geisslinger, G.
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Smelcerovic, A., Zivkovic, A., Ilic, B.S., Kolarevic, A., Hofmann, B., Steinhilber, D., Stark, H.
4-(4-Chlorophenyl)thiazol-2-amines as pioneers of potential neurodegenerative therapeutics with anti-inflammatory properties based on dual DNase I and 5-LO inhibition (2020) Bioorganic chemistry, 95, 103528. DOI: 10.1016/j.bioorg.2019.103528

Snodgrass, R.G., Benatzy, Y., Schmid, T., Namgaladze, D., Mainka, M., Schebb, N.H., Lütjohann, D., Brüne, B.
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Solbach, P., Chhatwal, P., Woltemate, S., Tacconelli, E., Buhl, M., Autenrieth, I.B., Vehreschild, M.J.G.T., Jazmati, N., Gerhard, M., Stein-Thoeringer, C.K., Rupp, J., Ulm, K., Ott, A., Lasch, F., Koch, A., Manns, M.P., Suerbaum, S., Bachmann, O.
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Stallmach, A., Sturm, A., Blumenstein, I., Helwig, U., Koletzko, S., Lynen, P., Schmidt, C., Dignaß, A., Kucharzik, T.
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Stallmach, A., Sturm, A., Blumenstein, I., Helwig, U., Koletzko, S., Lynen, P., Schmidt, C., Dignaß, A., Kucharzik, T.
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Stallmach, A., Sturm, A., Blumenstein, I., Helwig, U., Koletzko, S., Lynen, P., Schmidt, C., Dignass, A., Kucharzik, T.
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Strack, E., Rolfe, P.A., Fink, A.F., Bankov, K., Schmid, T., Solbach, C., Savai, R., Sha, W., Pradel, L., Hartmann, S., Brüne, B., Weigert, A.
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Stürner, K.H., Werz, O., Koeberle, A., Otto, M., Pless, O., Leypoldt, F., Paul, F., Heesen, C.
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Syed, S.N., Brüne, B.
MicroRNAs as Emerging Regulators of Signaling in the Tumor Microenvironment (2020) Cancers, 12 (4). DOI: 10.3390/cancers12040911

Syed, S.N., Weigert, A., Brüne, B.
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Takeuchi, Y., Okinaka, Y., Ogawa, Y., Kikuchi-Taura, A., Kataoka, Y., Gul, S., Claussen, C., Boltze, J., Taguchi, A.
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Thalman, C., Horta, G., Qiao, L., Endle, H., Tegeder, I., Cheng, H., Laube, G., Sigurdsson, T., Hauser, M.J., Tenzer, S., Distler, U., Aoki, J., Morris, A.J., Geisslinger, G., Röper, J., Kirischuk, S., Luhmann, H.J., Radyushkin, K., Nitsch, R., Vogt, J.
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Toptan, T., Hoehl, S., Westhaus, S., Bojkova, D., Berger, A., Rotter, B., Hoffmeier, K., Cinatl, J., JR, Ciesek, S., Widera, M.
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Trümper, V., Wittig, I., Heidler, J., Richter, F., Brüne, B., Knethen, A. von
Redox Regulation of PPARγ in Polarized Macrophages (2020) PPAR research, 2020, 8253831. DOI: 10.1155/2020/8253831

Tsakmaklis, A., Vehreschild, M., Farowski, F., Trommer, M., Kohler, C., Herter, J., Marnitz, S.
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van der Meer, A.-M., Berger, T., Müller, F., Foldenauer, A.C., Johnen, S., Walter, P.
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Vehreschild, M.J.G.T., Tsakmaklis, A., Nitschmann, S.
Intestinale Mikrobiota – Prädiktor für Mortalität nach Stammzelltransplantation (2020) Der Internist, 61 (9), 992–994. DOI: 10.1007/s00108-020-00819-8

Vehreschild, M.J.G.T., Tacconelli, E., Giske, C.G., Peschel, A.
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Visser, M., van Oerle, R., Cate, H. ten, Laux, V., Mackman, N., Heitmeier, S., Spronk, H.M.H.
Plasma Kallikrein Contributes to Coagulation in the Absence of Factor XI by Activating Factor IX (2020) Arteriosclerosis, thrombosis, and vascular biology, 40 (1), 103–111. DOI: 10.1161/ATVBAHA.119.313503

Vogel, A., Wilken-Schmitz, A., Hummel, R., Lang, M., Gurke, R., Schreiber, Y., Schäfer, M.K.E., Tegeder, I.
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Tax1BP1 limits hepatic inflammation and reduces experimental hepatocarcinogenesis (2020) Scientific reports, 10 (1), 16264. DOI: 10.1038/s41598-020-73387-4

Weber, S., Scheich, S., Magh, A., Wolf, S., Enßle, J.C., Brunnberg, U., Reinheimer, C., Wichelhaus, T.A., Kempf, V.A.J., Kessel, J., Vehreschild, M.J.G.T., Serve, H., Bug, G., Steffen, B., Hogardt, M.
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Weiss, R., Loth, A., Guderian, D., Diensthuber, M., Kempf, V., Hack, D., Wicker, S., Ciesek, S., Graf, J., Stöver, T., Leinung, M.
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Weiss, U., Möller, M., Husseini, S.A., Manderscheid, C., Häusler, J., Geisslinger, G., Niederberger, E.
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Wetzstein, N., Kohl, T.A., Andres, S., Schultze, T.G., Geil, A., Kim, E., Biciusca, T., Hügel, C., Hogardt, M., Lehn, A., Vehreschild, M.J.G.T., Wolf, T., Niemann, S., Maurer, F.P., Wichelhaus, T.A.
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Wetzstein, N., Kohl, T.A., Schultze, T.G., Andres, S., Bellinghausen, C., Hügel, C., Kempf, V.A.J., Lehn, A., Hogardt, M., Serve, H., Vehreschild, M.J.G.T., Wolf, T., Niemann, S., Maurer, F.P., Wichelhaus, T.A.
Antimicrobial Susceptibility and Phylogenetic Relations in a German Cohort Infected with Mycobacterium abscessus (2020) Journal of clinical microbiology, 58 (12). DOI: 10.1128/JCM.01813-20

Wigington, C.P., Roy, J., Damle, N.P., Yadav, V.K., Blikstad, C., Resch, E., Wong, C.J., Mackay, D.R., Wang, J.T., Krystkowiak, I., Bradburn, D.A., Tsekitsidou, E., Hong, S.H., Kaderali, M.A., Xu, S.-L., Stearns, T., Gingras, A.-C., Ullman, K.S., Ivarsson, Y., Davey, N.E., Cyert, M.S.
Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling (2020) Molecular cell, 79 (2), 342-358.e12. DOI: 10.1016/j.molcel.2020.06.029

Willems, S., Kilu, W., Ni, X., Chaikuad, A., Knapp, S., Heering, J., Merk, D.
The orphan nuclear receptor Nurr1 is responsive to non-steroidal anti-inflammatory drugs (2020) Communications Chemistry, 3 (1). DOI: 10.1038/s42004-020-0331-0

Witt, G., Keminer, O., Leu, J., Tandon, R., Meiser, I., Willing, A., Winschel, I., Abt, J.-C., Brändl, B., Sébastien, I., Friese, M.A., Müller, F.-J., Neubauer, J.C., Claussen, C., Zimmermann, H., Gribbon, P., Pless, O.
An automated and high-throughput-screening compatible pluripotent stem cell-based test platform for developmental and reproductive toxicity assessment of small molecule compounds (2020) Cell biology and toxicology . DOI: 10.1007/s10565-020-09538-0

Wolters, M.C., Schmetzer, J., Möser, C.V., Hahnefeld, L., Angioni, C., Thomas, D., Ferreirós, N., Geisslinger, G., Niederberger, E.
Exercise-Induced Changes in Bioactive Lipids Might Serve as Potential Predictors of Post-Exercise Hypotension. A Pilot Study in Healthy Volunteers (2020) Cells, 9 (9). DOI: 10.3390/cells9092111

Xanthopoulou, K., Peter, S., Tobys, D., Behnke, M., Dinkelacker, A.G., Eisenbeis, S., Falgenhauer, J., Falgenhauer, L., Fritzenwanker, M., Gölz, H., Häcker, G., Higgins, P.G., Imirzalioglu, C., Käding, N., Kern, W.V., Kramme, E., Kola, A., Mischnik, A., Rieg, S., Rohde, A.M., Rupp, J., Tacconelli, E., Vehreschild, M.J.G.T., Walker, S.V., Gastmeier, P., Seifert, H.
Vancomycin-resistant Enterococcus faecium colonizing patients on hospital admission in Germany: prevalence and molecular epidemiology (2020) The Journal of antimicrobial chemotherapy, 75 (10), 2743–2751. DOI: 10.1093/jac/dkaa271

Zavaritskaya, O., Dudem, S., Ma, D., Rabab, K.E., Albrecht, S., Tsvetkov, D., Kassmann, M., Thornbury, K., Mladenov, M., Kammermeier, C., Sergeant, G., Mullins, N., Wouappi, O., Wurm, H., Kannt, A., Gollasch, M., Hollywood, M.A., Schubert, R.
Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and K(v) 7 channels (2020) British journal of pharmacology, 177 (5), 1164–1186. DOI: 10.1111/bph.14910

Zhao, X.-Y., Wilmen, A., Wang, D., Wang, X., Bauzon, M., Kim, J.-Y., Linden, L., Li, L., Egner, U., Marquardt, T., Moosmayer, D., Tebbe, J., Glück, J.M., Ellinger, P., McLean, K., Yuan, S., Yegneswaran, S., Jiang, X., Evans, V., Gu, J.-M., Schneider, D., Zhu, Y., Xu, Y., Mallari, C., Hesslein, A., Wang, Y., Schmidt, N., Gutberlet, K., Ruehl-Fehlert, C., Freyberger, A., Hermiston, T., Patel, C., Sim, D., Mosnier, L.O., Laux, V.
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia (2020) Nature communications, 11 (1), 2992. DOI: 10.1038/s41467-020-16720-9

Ziegler, N., Bader, E., Epanchintsev, A., Margerie, D., Kannt, A., Schmoll, D.
AMPKβ1 and AMPKβ2 define an isoform-specific gene signature in human pluripotent stem cells, differentially mediating cardiac lineage specification (2020) The Journal of biological chemistry, 295 (51), 17659–17671. DOI: 10.1074/jbc.RA120.013990

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A - C

Annak, O., Heidegger, T., Walter, C., Deichmann, R., Nöth, U., Hansen-Goos, O., Ziemann, U., Lötsch, J.
Effects of continuous theta-burst stimulation of the primary motor and secondary somatosensory areas on the central processing and the perception of trigeminal nociceptive input in healthy volunteers (2019) Pain, 160 (1), 172–186. http://doi.org/10.1097/j.pain.0000000000001393

Astakhova, A., Chistyakov, D., Thomas, D., Geisslinger, G., Brüne, B., Sergeeva, M., Namgaladze, D.
Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization (2019) Cells, 8 (10). http://doi.org/10.3390/cells8101185

Bärnthaler, T., Jandl, K., Sill, H., Uhl, B., Schreiber, Y., Grill, M., Thomas, D., Schicho, R., Marsche, G., Frank, S., Heinemann, A., Schuligoi, R.
Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation (2019) The Journal of allergy and clinical immunology, 143 (2), 794-797.e10. http://doi.org/10.1016/j.jaci.2018.09.030

Bazarganipour, S., Hausmann, J., Oertel, S., El-Hindi, K., Brachtendorf, S., Blumenstein, I., Kubesch, A., Sprinzl, K., Birod, K., Hahnefeld, L., Trautmann, S., Thomas, D., Herrmann, E., Geisslinger, G., Schiffmann, S., Grösch, S.
The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated (2019) Journal of clinical medicine, 8 (7). http://doi.org/10.3390/jcm8070971

Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Use of a "critical difference" statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis (2019) BMC rheumatology, 3, 51. http://doi.org/10.1186/s41927-019-0095-2

Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Wittig, B.M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis (2019) Scandinavian journal of rheumatology, 48 (5), 375–382. http://doi.org/10.1080/03009742.2019.1600717

Berben, P., Ashworth, L., Beato, S., Bevernage, J., Bruel, J.-L., Butler, J., Dressman, J.B., Schäfer, K., Hutchins, P., Klumpp, L., Mann, J., Nicolai, J., Ojala, K., Patel, S., Powell, S., Rosenblatt, K., Tomaszewska, I., Williams, J., Augustijns, P.
Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 140, 141–148. http://doi.org/10.1016/j.ejpb.2019.04.017

Bhaskara, R.M., Grumati, P., Garcia-Pardo, J., Kalayil, S., Covarrubias-Pinto, A., Chen, W., Kudryashev, M., Dikic, I., Hummer, G.
Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy (2019) Nature communications, 10 (1), 2370. http://doi.org/10.1038/s41467-019-10345-3

Bhogaraju, S., Bonn, F., Mukherjee, R., Adams, M., Pfleiderer, M.M., Galej, W.P., Matkovic, V., Lopez-Mosqueda, J., Kalayil, S., Shin, D., Dikic, I.
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation (2019) Nature, 572 (7769), 382–386. http://doi.org/10.1038/s41586-019-1440-8

Bode, E., Heinrich, A.K., Hirschmann, M., Abebew, D., Shi, Y.-N., Vo, T.D., Wesche, F., Shi, Y.-M., Grün, P., Simonyi, S., Keller, N., Engel, Y., Wenski, S., Bennet, R., Beyer, S., Bischoff, I., Buaya, A., Brandt, S., Cakmak, I., Çimen, H., Eckstein, S., Frank, D., Fürst, R., Gand, M., Geisslinger, G., Hazir, S., Henke, M., Heermann, R., Lecaudey, V., Schäfer, W., Schiffmann, S., Schüffler, A., Schwenk, R., Skaljac, M., Thines, E., Thines, M., Ulshöfer, T., Vilcinskas, A., Wichelhaus, T.A., Bode, H.B.
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (2019) Angewandte Chemie (International ed. in English), 58 (52), 18957–18963. http://doi.org/10.1002/anie.201910563

Borsari, C., Jiménez-Antón, M.D., Eick, J., Bifeld, E., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Santarem, N., Baptista, C., Severi, L., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Linciano, P., Tait, A., Costantino, L., Luciani, R., Tejera Nevado, P., Zander-Dinse, D., Franco, C.H., Ferrari, S., Moraes, C.B., Cordeiro-da-Silva, A., Ponterini, G., Clos, J., Alunda, J.M., Costi, M.P.
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics (2019) European journal of medicinal chemistry, 183, 111676. http://doi.org/10.1016/j.ejmech.2019.111676

Borsari, C., Santarem, N., Macedo, S., Jiménez-Antón, M.D., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Tait, A., Ferrari, S., Costantino, L., Luciani, R., Ponterini, G., Gul, S., Kuzikov, M., Ellinger, B., Behrens, B., Reinshagen, J., Alunda, J.M., Cordeiro-da-Silva, A., Costi, M.P.
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent (2019) ACS medicinal chemistry letters, 10 (4), 528–533. http://doi.org/10.1021/acsmedchemlett.8b00565

Braun, J., Schwarting, A., Hammel, L., Legeler, C., Wimmer, P., Färber, L., Behrens, F.
Versorgungssituation von Patienten mit ankylosierender Spondylitis und Psoriasisarthritis in Deutschland : Versorgungssituation von Patienten mit Spondyloarthritis (SpA): Ankylosierende Spondylitis (AS) und Psoriasisarthritis (PsA) aus der Sicht von niedergelassenen und in Kliniken tätigen Rheumatologen in Deutschland – Ergebnisse des Forschungsprojekts „SpA Loop – Life of Outpatients“ (2019) Zeitschrift fur Rheumatologie, 78 (4), 372–381. http://doi.org/10.1007/s00393-019-0619-6

Brennecke, P., Rasina, D., Aubi, O., Herzog, K., Landskron, J., Cautain, B., Vicente, F., Quintana, J., Mestres, J., Stechmann, B., Ellinger, B., Brea, J., Kolanowski, J.L., Pilarski, R., Orzaez, M., Pineda-Lucena, A., Laraia, L., Nami, F., Zielenkiewicz, P., Paruch, K., Hansen, E., Kries, J.P. von, Neuenschwander, M., Specker, E., Bartunek, P., Simova, S., Leśnikowski, Z., Krauss, S., Lehtiö, L., Bilitewski, U., Brönstrup, M., Taskén, K., Jirgensons, A., Lickert, H., Clausen, M.H., Andersen, J.H., Vicent, M.J., Genilloud, O., Martinez, A., Nazaré, M., Fecke, W., Gribbon, P.
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology (2019) SLAS discovery : advancing life sciences R & D, 24 (3), 398–413. http://doi.org/10.1177/2472555218816276

Brunkhorst-Kanaan, N., Klatt-Schreiner, K., Hackel, J., Schröter, K., Trautmann, S., Hahnefeld, L., Wicker, S., Reif, A., Thomas, D., Geisslinger, G., Kittel-Schneider, S., Tegeder, I.
Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder (2019) Metabolism: clinical and experimental, 95, 65–76. http://doi.org/10.1016/j.metabol.2019.04.002

Chen, C., Kramer, J.S., Brunst, S., Proschak, E., Scriba, G.K.E.
Capillary electrophoresis-based enzyme assays for β-lactamase enzymes (2019) Electrophoresis, 40 (18-19), 2375–2381. http://doi.org/10.1002/elps.201900104

Choy, E., Baraliakos, X., Behrens, F., D'Angelo, S., Vlam, K. de, Kirkham, B.W., Østergaard, M., Schett, G.A., Rissler, M., Chaouche-Teyara, K., Perella, C.
The need for comparative data in spondyloarthritis (2019) Arthritis research & therapy, 21 (1), 32. http://doi.org/10.1186/s13075-019-1812-3

Cristofoletti, R., Hens, B., Patel, N., Esteban, V.V., Schmidt, S., Dressman, J.B.
Integrating Drug- and Formulation-Related Properties With Gastrointestinal Tract Variability Using a Product-Specific Particle Size Approach: Case Example Ibuprofen (2019) Journal of pharmaceutical sciences, 108 (12), 3842–3847. http://doi.org/10.1016/j.xphs.2019.09.012

D – F

Dauth, S., Köhm, M., Behrens, F.
Psoriatic arthritis: combinational therapy of biologics and methotrexate - What do we know? (2019) Clinical Trials in Degenerative Diseases, 4 (4), 0. http://doi.org/10.4103/2542-3975.274078

Deutschmann, J., Schneider, A., Gruska, I., Vetter, B., Thomas, D., Kießling, M., Wittmann, S., Herrmann, A., Schindler, M., Milbradt, J., Ferreirós, N., Winkler, T.H., Wiebusch, L., Gramberg, T.
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1 (2019) Nature microbiology, 4 (12), 2273–2284. http://doi.org/10.1038/s41564-019-0529-z

Ditzinger, F., Price, D.J., Nair, A., Becker-Baldus, J., Glaubitz, C., Dressman, J.B., Saal, C., Kuentz, M.
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies (2019) Pharmaceutics, 11 (11). http://doi.org/10.3390/pharmaceutics11110577

Dreis, C., Ottenlinger, F.M., Putyrski, M., Ernst, A., Huhn, M., Schmidt, K.G., Pfeilschifter, J.M., Radeke, H.H.
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs (2019) Frontiers in immunology, 10, 1698. http://doi.org/10.3389/fimmu.2019.01698

Dufrusine, B., Di Francesco, A., Oddi, S., Scipioni, L., Angelucci, C.B., D'Addario, C., Serafini, M., Häfner, A.-K., Steinhilber, D., Maccarrone, M., Dainese, E.
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation (2019) Frontiers in immunology, 10, 1347. http://doi.org/10.3389/fimmu.2019.01347

Ehrnhoefer, D.E., Skotte, N.H., Reinshagen, J., Qiu, X., Windshügel, B., Jaishankar, P., Ladha, S., Petina, O., Khankischpur, M., Nguyen, Y.T.N., Caron, N.S., Razeto, A., Meyer Zu Rheda, M., Deng, Y., Huynh, K.T., Wittig, I., Gribbon, P., Renslo, A.R., Geffken, D., Gul, S., Hayden, M.R.
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound (2019) Cell chemical biology, 26 (9), 1295-1305.e6. http://doi.org/10.1016/j.chembiol.2019.07.001

Elwakeel, E., Brüggemann, M., Fink, A.F., Schulz, M.H., Schmid, T., Savai, R., Brüne, B., Zarnack, K., Weigert, A.
Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development (2019) International journal of molecular sciences, 20 (18). http://doi.org/10.3390/ijms20184438

Elzahhar, P.A., Alaaeddine, R., Ibrahim, T.M., Nassra, R., Ismail, A., Chua, B.S.K., Frkic, R.L., Bruning, J.B., Wallner, N., Knape, T., von Knethen, A., Labib, H., El-Yazbi, A.F., Belal, A.S.F.
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones (2019) European journal of medicinal chemistry, 167, 562–582. http://doi.org/10.1016/j.ejmech.2019.02.034

Englbrecht, M., Alten, R., Aringer, M., Baerwald, C.G., Burkhardt, H., Eby, N., Flacke, J.-P., Fliedner, G., Henkemeier, U., Hofmann, M.W., Kleinert, S., Kneitz, C., Krüger, K., Pohl, C., Schett, G.A., Schmalzing, M., Tausche, A.-K., Tony, H.-P., Wendler, J.
New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis - Implications from the prospective multicenter VADERA II study (2019) PloS one, 14 (5), e0217412. http://doi.org/10.1371/journal.pone.0217412

Feczkó, T., Piiper, A., Ansar, S., Blixt, F.W., Ashtikar, M., Schiffmann, S., Ulshöfer, T., Parnham, M.J., Harel, Y., Israel, L.L., Lellouche, J.-P., Wacker, M.G.
Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy (2019) Journal of controlled release : official journal of the Controlled Release Society, 293, 63–72. http://doi.org/10.1016/j.jconrel.2018.11.017

Fettel, J., Kühn, B., Guillen, N.A., Sürün, D., Peters, M., Bauer, R., Angioni, C., Geisslinger, G., Schnütgen, F., Meyer Zu Heringdorf, D., Werz, O., Meybohm, P., Zacharowski, K., Steinhilber, D., Roos, J., Maier, T.J.
Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity (2019) FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (2), 1711–1726. http://doi.org/10.1096/fj.201800221R

Fuhrmann, D.C., Olesch, C., Kurrle, N., Schnütgen, F., Zukunft, S., Fleming, I., Brüne, B.
Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins (2019) Cells, 8 (2). http://doi.org/10.3390/cells8020172

G – I

Göbel, T., Diehl, O., Heering, J., Merk, D., Angioni, C., Wittmann, S.K., La Buscato, E., Kottke, R., Weizel, L., Schader, T., Maier, T.J., Geisslinger, G., Schubert-Zsilavecz, M., Steinhilber, D., Proschak, E., Kahnt, A.S.
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Paraiso, R.L.M., Watanabe, A., Andreas, C.J., Turner, D.B., Zane, P., Dressman, J.B.
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Parnham, M.J., Geisslinger, G.
Pharmacological plasticity-How do you hit a moving target? (2019) Pharmacology research & perspectives, 7 (6), e00532. http://doi.org/10.1002/prp2.532

Parnham, M.J., Nijkamp, F.P., Rossi, A.G.
Nijkamp and Parnham's Principles of Immunopharmacology (2019). Springer International Publishing. http://doi.org/10.1007/978-3-030-10811-3

Pentafragka, C., Symillides, M., McAllister, M., Dressman, J.B., Vertzoni, M., Reppas, C.
The impact of food intake on the luminal environment and performance of oral drug products with a view to in vitro and in silico simulations: a PEARRL review (2019) The Journal of pharmacy and pharmacology, 71 (4), 557–580. http://doi.org/10.1111/jphp.12999

Pohl, C., Dikic, I.
Cellular quality control by the ubiquitin-proteasome system and autophagy (2019) Science (New York, N.Y.), 366 (6467), 818–822. http://doi.org/10.1126/science.aax3769

Pollinger, J., Gellrich, L., Schierle, S., Kilu, W., Schmidt, J., Kalinowsky, L., Ohrndorf, J., Kaiser, A., Heering, J., Proschak, E., Merk, D.
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation (2019) Journal of medicinal chemistry, 62 (4), 2112–2126. http://doi.org/10.1021/acs.jmedchem.8b01848

Poluzzi, C., Nastase, M.-V., Zeng-Brouwers, J., Roedig, H., Hsieh, L.T.-H., Michaelis, J.B., Buhl, E.M., Rezende, F., Manavski, Y., Bleich, A., Boor, P., Brandes, R.P., Pfeilschifter, J.M., Stelzer, E.H.K., Münch, C., Dikic, I., Brandts, C.H., Iozzo, R.V., Wygrecka, M., Schaefer, L.
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Proschak, E., Stark, H., Merk, D.
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds (2019) Journal of medicinal chemistry, 62 (2), 420–444. http://doi.org/10.1021/acs.jmedchem.8b00760

Queck, A., Thomas, D., Jansen, C., Schreiber, Y., Rüschenbaum, S., Praktiknjo, M., Schwarzkopf, K.M., Mücke, M.M., Schierwagen, R., Uschner, F.E., Meyer, C., Clària, J., Zeuzem, S., Geisslinger, G., Trebicka, J., Lange, C.M.
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Surface Activity Profiling (SAP): A potential means of predicting intestinal membrane permeability (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 142, 291–299. http://doi.org/10.1016/j.ejpb.2019.06.024

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Application of a Refined Developability Classification System (2019) Journal of pharmaceutical sciences, 108 (3), 1090–1100. http://doi.org/10.1016/j.xphs.2018.10.044

Rühl, M., Kühn, B., Roos, J., Maier, T.J., Steinhilber, D., Karas, M.
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Saul, M.J., Emmerich, A.C., Steinhilber, D., Suess, B.
Regulation of Eicosanoid Pathways by MicroRNAs (2019) Frontiers in pharmacology, 10, 824. http://doi.org/10.3389/fphar.2019.00824

Saul, M.J., Hegewald, A.B., Emmerich, A.C., Ossipova, E., Vogel, M., Baumann, I., Kultima, K., Lengqivst, J., Steinhilber, D., Jakobsson, P.-J.
Mass Spectrometry-Based Proteomics Approach Characterizes the Dual Functionality of miR-328 in Monocytes (2019) Frontiers in pharmacology, 10, 640. http://doi.org/10.3389/fphar.2019.00640

Schmiedl, S., Peters, D., Schmalz, O., Mielke, A., Rossmanith, T., Diop, S., Piefke, M., Thürmann, P., Schmidtko, A.
Loxapine for Treatment of Patients With Refractory, Chemotherapy-Induced Neuropathic Pain: A Prematurely Terminated Pilot Study Showing Efficacy But Limited Tolerability (2019) Frontiers in pharmacology, 10, 838. http://doi.org/10.3389/fphar.2019.00838

Schmitz, K., Wilken-Schmitz, A., Vasic, V., Brunkhorst, R., Schmidt, M., Tegeder, I.
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Schwarzkopf, K.M., Queck, A., Thomas, D., Angioni, C., Cai, C., Freygang, Y., Rüschenbaum, S., Geisslinger, G., Zeuzem, S., Welsch, C., Lange, C.M.
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Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors (2019) Scientific reports, 9 (1), 12297. http://doi.org/10.1038/s41598-019-48814-w

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Smelcerovic, A., Zivkovic, A., Ilic, B.S., Kolarevic, A., Hofmann, B., Steinhilber, D., Stark, H.
4-(4-Chlorophenyl)thiazol-2-amines as pioneers of potential neurodegenerative therapeutics with anti-inflammatory properties based on dual DNase I and 5-LO inhibition (2019) Bioorganic chemistry, 95, 103528. http://doi.org/10.1016/j.bioorg.2019.103528

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Snodgrass, R.G., Brüne, B.
Regulation and Functions of 15-Lipoxygenases in Human Macrophages (2019) Frontiers in pharmacology, 10, 719. http://doi.org/10.3389/fphar.2019.00719

Susen, R.M., Bauer, R., Olesch, C., Fuhrmann, D.C., Fink, A.F., Dehne, N., Jain, A., Ebersberger, I., Schmid, T., Brüne, B.
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MicroRNA-A Tumor Trojan Horse for Tumor-Associated Macrophages (2019) Cells, 8 (12). http://doi.org/10.3390/cells8121482

Syed, S.N., Raue, R., Weigert, A., von Knethen, A., Brüne, B.
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Tarighi, N., Menger, D., Pierre, S., Kornstädt, L., Thomas, D., Ferreirós, N., Nüsing, R.M., Geisslinger, G., Scholich, K.
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Tiku, V., Dikic, I.
Autophagy without conjugation (2019) Nature structural & molecular biology, 26 (4), 249–250. http://doi.org/10.1038/s41594-019-0207-0

Trümper, V., von Knethen, A., Preuß, A., Ermilov, E., Hackbarth, S., Kuchler, L., Gunne, S., Schäfer, A., Bornhütter, T., Vereb, G., Ujlaky-Nagy, L., Brüne, B., Röder, B., Schindler, M., Parnham, M.J., Knape, T.
Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells (2019) Theranostics, 9 (19), 5444–5463. http://doi.org/10.7150/thno.29367

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van Wijk, S.J., Fulda, S., Dikic, I., Heilemann, M.
Visualizing ubiquitination in mammalian cells (2019) EMBO reports, 20 (2). http://doi.org/10.15252/embr.201846520

Vasconez, A.E., Janetzko, P., Oo, J.A., Pflüger-Müller, B., Ratiu, C., Gu, L., Helin, K., Geisslinger, G., Fleming, I., Schröder, K., Fork, C., Brandes, R.P., Leisegang, M.S.
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Vieider, L., Romp, E., Temml, V., Fischer, J., Kretzer, C., Schoenthaler, M., Taha, A., Hernández-Olmos, V., Sturm, S., Schuster, D., Werz, O., Garscha, U., Matuszczak, B.
Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors (2019) ACS medicinal chemistry letters, 10 (1), 62–66. http://doi.org/10.1021/acsmedchemlett.8b00415

Villa Nova, M., Nothnagel, L., Thurn, M., Travassos, P.B., Herculano, L.S., Bittencourt, P.R.S., Novello, C.R., Bazotte, R.B., Wacker, M.G., Bruschi, M.L.
Development study of pectin/Surelease® solid microparticles for the delivery of L-alanyl-L-glutamine dipeptide (2019) Food Hydrocolloids, 89, 921–932. http://doi.org/10.1016/j.foodhyd.2018.11.038

von Knethen, A., Brüne, B.
Histone Deacetylation Inhibitors as Therapy Concept in Sepsis (2019) International journal of molecular sciences, 20 (2). http://doi.org/10.3390/ijms20020346

von Knethen, A., Brüne, B.
PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology (2019) Signal transduction and targeted therapy, 4, 18. http://doi.org/10.1038/s41392-019-0053-x

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Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis (2019) Theranostics, 9 (7), 2003–2016. http://doi.org/10.7150/thno.28057

Wallenwein, C.M., Villa Nova, M., Janas, C., Jablonka, L., Gao, G.F., Thurn, M., Albrecht, V., Wiehe, A., Wacker, M.G.
A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 143, 44–50. http://doi.org/10.1016/j.ejpb.2019.08.010

Walter, C., Oertel, B.G., Felden, L., Nöth, U., Deichmann, R., Lötsch, J.
Delta-9-tetrahydrocannabinol reduces the performance in sensory delayed discrimination tasks. A pharmacological-fMRI study in healthy volunteers (2019) IBRO reports, 7, 117–128. http://doi.org/10.1016/j.ibror.2019.11.004

Wegner, M.-S., Gruber, L., Schömel, N., Trautmann, S., Brachtendorf, S., Fuhrmann, D.C., Schreiber, Y., Olesch, C., Brüne, B., Geisslinger, G., Grösch, S.
GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells (2019) The international journal of biochemistry & cell biology, 112, 95–106. http://doi.org/10.1016/j.biocel.2019.05.002

Wegner, M., Diehl, V., Bittl, V., Bruyn, R. de, Wiechmann, S., Matthess, Y., Hebel, M., Hayes, M.G., Schaubeck, S., Benner, C., Heinz, S., Bremm, A., Dikic, I., Ernst, A., Kaulich, M.
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome (2019) eLife, 8. http://doi.org/10.7554/eLife.42549

Weigert, A., Olesch, C., Brüne, B.
Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater (2019) Frontiers in immunology, 10, 1706. http://doi.org/10.3389/fimmu.2019.01706

Weigert, A., von Knethen, A., Thomas, D., Faria, I., Namgaladze, D., Zezina, E., Fuhrmann, D.C., Petcherski, A., Heringdorf, D.M.Z., Radeke, H.H., Brüne, B.
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TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers (2019) The Clinical journal of pain, 35 (4), 321–327. http://doi.org/10.1097/AJP.0000000000000677

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Yuki, K.E., Marei, H., Fiskin, E., Eva, M.M., Gopal, A.A., Schwartzentruber, J.A., Majewski, J., Cellier, M., Mandl, J.N., Vidal, S.M., Malo, D., Dikic, I.
CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection (2019) Nature microbiology, 4 (9), 1516–1531. http://doi.org/10.1038/s41564-019-0484-8

Zschiebsch, K., Fischer, C., Wilken-Schmitz, A., Geisslinger, G., Channon, K., Watschinger, K., Tegeder, I.
Mast cell tetrahydrobiopterin contributes to itch in mice (2019) Journal of cellular and molecular medicine, 23 (2), 985–1000. http://doi.org/10.1111/jcmm.13999

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Therapeutics discovery: from bench to first in-human trials (2018) Biomedical Reports, 8, 275-282. http://doi.org/10.3892/br.2018.1052

Alten, R., Burkhardt, H., Feist, E., Krüger, K., Rech, J., Rubbert-Roth, A., Voll, R.E., Elbez, Y., Rauch, C.
Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: A descriptive analysis of data from interventional trials and the real-world setting (2018) Arthritis Research and Therapy, 20 (1), 1. http://doi.org/10.1186/s13075-017-1488-5

Ashtikar, M., Wacker, M.G.
Nanopharmaceuticals for wound healing – Lost in translation? (2018) Advanced Drug Delivery Reviews, 129, 194-218. http://doi.org/10.1016/j.addr.2018.03.005

Aygören-Pürsün, E., Bygum, A., Grivcheva-Panovska, V., Magerl, M., Graff, J., Steiner, U.C., Fain, O., Huissoon, A., Kinaciyan, T., Farkas, H., Lleonart, R., Longhurst, H.J., Rae, W., Triggiani, M., Aberer, W., Cancian, M., Zanichelli, A., Smith, W.B., Baeza, M.L., Du-Thanh, A., Gompels, M., Gonzalez-Quevedo, T., Greve, J., Guilarte, M., Katelaris, C., Dobo, S., Cornpropst, M., Clemons, D., Fang, L., Collis, P., Sheridan, W., Maurer, M., Cicardi, M.
Oral plasma kallikrein inhibitor for prophylaxis in hereditary angioedema (2018) New England Journal of Medicine, 379 (4), 352-362. http://doi.org/10.1056/NEJMoa1716995

Badalyan, G., Díaz, C., Bücking, M., Lipski, A.
Novel sensor platform for rapid detection and quantification of coliforms on food contact surfaces (2018) Journal of Microbiological Methods, 153, 74-83. http://doi.org/10.1016/j.mimet.2018.09.009

Behrens, F., Koehm, M., Schwaneck, E.C., Schmalzing, M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
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Behrens, F., Meier, L., Prinz, J.C., Jobst, J., Lippe, R., Löschmann, P.-A., Lorenz, H.-M.
Simultaneous response in several domains in patients with psoriatic disease treated with etanercept as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (2018) Journal of Rheumatology, 45 (6), 802-810. http://doi.org/10.3899/jrheum.170932

Blum, L., Schiffmann, S., Parnham, M.J.
Immunomodulation by antibiotics (2018) Fighting Antimicrobial Resistance (IAPC Book). http://doi.org/10.5599/obp.15.11

Blum, L., Tafferner, N., Spring, I., Kurz, J., deBruin, N., Geißlinger, G., Parnham, M.J., Schiffmann, S.
Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression (2018) Journal of Molecular Medicine, 96 (10), 1131-1144. http://doi.org/10.1007/s00109-018-1689-7

Böhm, B.B., Fehrl, Y., Janczi, T., Schneider, N., Burkhardt, H.
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Bosma, R., Witt, G., Vaas, L.A.I., Josimovic, I., Gribbon, P., Vischer, H.F., Gul, S., Leurs, R.
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Brachtendorf, S., Wanger, R.A., Birod, K., Thomas, D., Trautmann, S., Wegner, M.-S., Fuhrmann, D.C., Brüne, B., Geißlinger, G., Grösch, S.
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Brandt, S.C., Ellinger, B., van Nguyen, T., Thi, Q.D., van Nguyen, G., Baschien, C., Yurkov, A., Hahnke, R.L., Schäfer, W., Gand, M.
A unique fungal strain collection from Vietnam characterized for high performance degraders of bioecological important biopolymers and lipids (2018) PLoS ONE, 13(8). http://doi.org/10.1371/journal.pone.0202695

Büttner, D., Kramer, J.S., Klingler, F.-M., Wittmann, S.K., Hartmann, M.R., Kurz, C.G., Kohnhäuser, D., Weizel, L., Brüggerhoff, A., Frank, D., Steinhilber, D., Wichelhaus, T.A., Pogoryelov, D., Proschak, E.
Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases (2018) ACS Infectious Diseases, 4 (3), 360-372. http://doi.org/10.1021/acsinfecdis.7b00129

Burk, O., Kuzikov, M., Kronenberger, T., Jeske, J., Keminer, O., Thasler, W.E., Schwab, M., Wrenger, C., Windshügel, B.
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles (2018) Archives of Toxicology, 92 (4), 1435-1451. http://doi.org/10.1007/s00204-018-2165-4

D – F

Dauth, S., Köhm, M., Rossmanith, T., Herrmann, E., Lehn, A., Burkhardt, H., Behrens, F.
Stellenwert der Kombination von Biologika mit Methotrexat in der Behandlung der Psoriasisarthritis - Fragen bleiben offen (2018) Zeitschrift fur Rheumatologie.  http://doi.org/10.1007/s00393-018-0533-3

de Bruin, N., Ferreirós, N., Schmidt, M., Hofmann, M., Angioni, C., Geisslinger, G., Parnham, M.J. Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains (2018) Chirality, 30 (5), 632-641. http://doi.org/10.1002/chir.22826

de Witte, W.E.A., Versfelt, J.W., Kuzikov, M., Rolland, S., Georgi, V., Gribbon, P., Gul, S., Huntjens, D., van der Graaf, P.H., Danhof, M., Fernández-Montalván, A., Witt, G., de Lange, E.C.M.
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations (2018) Br J Pharmacol, 175 (21), 4121-4136. http://doi.org/10.1111/bph.14456

Eresch, J., Stumpf, M., Koch, A., Vutukuri, R., Ferreirós, N., Schreiber, Y., Schröder, K., Devraj, K., Popp, R., Hattenbach, L.-O., Pfeilschifter, J., Pfeilschifter, W.Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy(2018) Investigative Ophthalmology and Visual Science, 59 (2), 653-661. http://doi.org/10.1167/iovs.17-22544

Fiehn, C., Holle, J., Iking-Konert, C., Leipe, J., Weseloh, C., Frerix, M., Alten, R., Behrens, F., Baerwald, C., Braun, J., Burkhardt, H., Burmester, G., Detert, J., Gaubitz, M., Gause, A., Gromnica-Ihle, E., Kellner, H., Krause, A., Kuipers, J., Lorenz, H.-M., Müller-Ladner, U., Nothacker, M., Nüsslein, H., Rubbert-Roth, A., Schneider, M., Schulze-Koops, H., Seitz, S., Sitter, H., Specker, C., Tony, H.-P., Wassenberg, S., Wollenhaupt, J., Krüger, K.
S2e guideline: treatment of rheumatoid arthritis with disease-modifying drugs (2018) Zeitschrift fur Rheumatologie, 77, 35-53. http://doi.org/10.1007/s00393-018-0481-y

Genovese, M.C., Combe, B., Kremer, J.M., Tsai, T.-F., Behrens, F., Adams, D.H., Lee, C., Kerr, L., Nash, P.
Safety and efficacy of ixekizumab in patients with PsA and previous inadequate response to TNF inhibitors: week 52 results from SPIRIT-P2 (2018) Rheumatology (Oxford, England), 57 (11), 2001-2011. http://doi.org/10.1093/rheumatology/key182

Gossec, L., McGonagle, D., Korotaeva, T., Lubrano, E., De Miguel, E., Østergaard, M., Behrens, F. Minimal disease activity as a treatment target in psoriatic arthritis: A review of the literature (2018) Journal of Rheumatology, 45 (1), 6-13. http://doi.org/10.3899/jrheum.170449

Häupl, T., Skapenko, A., Hoppe, B., Skriner, K., Burkhardt, H., Poddubnyy, D., Ohrndorf, S., Sewerin, P., Mansmann, U., Stuhlmüller, B., Schulze-Koops, H., Burmester, G.R.
Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark (2018) Zeitschrift fur Rheumatologie, 77, 16-23. http://doi.org/10.1007/s00393-018-0458-x

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R.
Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos (2018) Environmental Science and Pollution Research, 25 (5), 4023-4036. http://doi.org/10.1007/s11356-017-8977-6

Heitel, P., Gellrich, L., Heering, J., Goebel, T., Kahnt, A., Proschak, E., Schubert-Zsilavecz, M., Merk, D.
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro (2018) Scientific Reports, 8 (1), 13554. http://doi.org/10.1038/s41598-018-31833-4

Hering, Y., Berthier, A., Duez, H., Lefebvre, P., Deprez, B., Gribbon, P., Wolf, M., Reinshagen, J., Halley, F., Hannemann, J., Böger, R., Staels, B., Gul, S.
Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα (2018) Journal of Biological Methods, 5 (3), e94. http://doi.org/10.1038/s41598-018-31833-4

Hitzel, J., Lee, E., Zhang, Y., Bibli, S.I., Li, X., Zukunft, S., Pflüger, B., Hu, J., Schürmann, C., Vasconez, A.E., Oo, J.A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C.E., Kroll, J., Jo, H., Landmesser, U., Lusis, A.J., Namgaladze, D., Fleming, I., Leisegang, M.S., Zhu, J., Brandes, R.P. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells (2018) Nature Communications, 9 (1), art. no. 2292. http://doi.org/10.1038/s41467-018-04602-0

Hofmann, M.C.J., Schmidt, M., Arne, O., Geisslinger, G., Parnham, M.J., de Bruin, N.M.W.J.
Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation (2018) Journal of Dermatological Science, 91 (2), 153-163. http://doi.org/10.1016/j.jdermsci.2018.04.013

Jung, F., Nothnagel, L., Gao, F., Thurn, M., Vogel, V., Wacker, M.G. A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling (2018) European Journal of Pharmaceutics and Biopharmaceutics, 127, 462-470. http://doi.org/10.1016/j.ejpb.2018.03.010

Kern, K., Schäfer, S.M.G., Cohnen, J., Pierre, S., Osthues, T., Tarighi, N., Hohmann, S., Ferreiros, N., Brüne, B., Weigert, A., Geißlinger, G., Sisignano, M., Scholich, K.
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue (2018) Frontiers in Immunology, 9, 2261. http://doi.org/10.3389/fimmu.2018.02261

Kirchner, J., Brüne, B., Namgaladze, D. AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages (2018) Scientific Reports, 8 (1), art. no. 7801, http://doi.org/10.1038/s41598-018-26102-3

Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreirós, N., Geißlinger, G., Batista, V.S., Ji, X., Cinatl, J. Jr., Keppler, O.T., Xiong, Y.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 (2018) Proceedings of the National Academy of Sciences of the United States of America, 115 (43), E10022-E10031. http://doi.org/10.1073/pnas.1805593115

Kraft, C., Boya, P., Codogno, P., Elazar, Z., Eskelinen, E.-L., Farrés, J., Kirkin, V., Jungbluth, H., Martinez, A., Pless, O., Primard, C., Proikas-Cezanne, T., Simonsen, A., Reggiori, F.
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy (2018) Autophagy. 13,1-5. Online first. http://doi.org/10.1080/15548627.2018.1515532Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E. A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E.
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kringel, D., Geißlinger, G., Resch, E., Oertel, B.G., Thrun,M.C., Heinemann, S., Lötsch, J.
Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin (2018) Pain, 159 (7), 1366-1381. http://doi.org/10.1097/j.pain.0000000000001222

Kringel, D., Kaunisto, M.A., Lippmann, C., Kalso, E., Lötsch, J.
Development of an AmpliSeqTMPanel for next-generation sequencing of a set of genetic predictors of persisting pain (2018) Frontiers in Pharmacology, 9, 1008. http://doi.org/10.3389/fphar.2018.01008

Kringel, D., Lippmann, C., Parnham, M.J., Kalso, E., Ultsch, A., Lötsch, J.
A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes (2018) European Journal of Pain, 22 (10), 1735-1756. http://doi.org/10.1002/ejp.1270

Kronenberger, T., Windshügel, B., Wrenger, C., Honorio, K.M., Maltarollo, V.G. On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity (2018) Journal of Biomolecular Structure and Dynamics, 1-14. Article in Press. http://doi.org/10.1080/07391102.2017.1417161

Kühn, B., Brat, C., Fettel, J., Hellmuth, N., Maucher, I.V., Bulut, U., Hock, K.J., Grimmer, J., Manolikakes, G., Rühl, M., Kühn, A., Zacharowski, K., Matrone, C., Urbschat, A., Roos, J., Steinhilber, D., Maier, T.J.
Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells (2018) Biochemical Pharmacology, 155, 48-60. http://doi.org/10.1016/j.bcp.2018.06.014

Kurz, J., Brunkhorst, R., Foerch, C., Blum, L., Henke, M., Gabriel, L., Ulshöfer, T., Ferreirós, N., Parnham, M.J., Geißlinger, G., Schiffmann, S.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis (2018) Clinical Science, 132 (17), 1963-1976. http://doi.org/10.1042/CS20180506

Linciano, P., Moraes, C.B., Alcantara, L.M., Franco, C.H., Pascoalino, B., Freitas-Junior, L.H., Macedo, S., Santarem, N., Cordeiro-da-Silva, A., Gul, S., Witt, G., Kuzikov, M., Ellinger, B., Ferrari, S., Luciani, R., Quotadamo, A., Costantino, L., Costi, M.P.
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections (2018) European Journal of Medicinal Chemistry, 25;146, 423-434. http://doi.org/10.1016/j.ejmech.2018.01.043

Lippmann, C., Kringel, D., Ultsch, A., Lötsch, J. Computational functional genomics-based approaches in analgesic drug discovery and repurposing (2018) Pharmacogenomics, 19 (9), 783-797. http://doi.org/10.2217/pgs-2018-0036

Lötsch, J., Geisslinger, G., Heinemann, S., Lerch, F., Oertel, B.G., Ultsch, A.
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: A machine-learned analysis (2018) Pain, 159 (1), 11-24. http://doi.org/10.1097/j.pain.0000000000001008

Lötsch, J., Kringel, D.
Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications (2018) Clinical Pharmacology and Therapeutics, . Article in Press. http://doi.org/10.1002/cpt.960

Lötsch, J., Lerch, F., Djaldetti, R., Tegder, I., Ultsch, A.
dentification of disease-distinct complex biomarker patterns by means of unsupervised machine-learning using an interactive R toolbox (Umatrix) (2018) BMC Big Data Analytics, 3. http://doi.org/10.1186/s41044-018-0032-1

Lötsch, J., Schiffmann, S., Schmitz, K., Brunkhorst, R., Lerch, F., Ferreiros, N., Wicker, S., Tegeder, I., Geißlinger, G., Ultsch, A.
Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy (2018) Scientific Reports, 8 (1), 14884. http://doi.org/10.1038/s41598-018-33077-8

Lötsch, J., Sipilä, R., Dimova, V., Kalso, E.
Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery (2018) British Journal of Anaesthesia, 121 (5), 1123-1132. http://doi.org/10.1016/j.bja.2018.06.007

Lötsch, J., Sipilä, R., Tasmuth, T., Kringel, D., Estlander, A.-M., Meretoja, T., Kalso, E., Ultsch, A. Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy (2018) Breast Cancer Research and Treatment, 1-13. Article in Press. http://doi.org/10.1007/s10549-018-4841-8

Lötsch, J., Ultsch, A.
Machine learning in pain research (2018) Pain, 159 (4), 623-630. http://doi.org/10.1097/j.pain.0000000000001118

Lötsch, J., Weyer-Menkhoff, I., Tegeder, I. Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings (2018) European Journal of Pain (United Kingdom), 22 (3), 471-484. http://doi.org/10.1002/ejp.1148

Lukin, A., Kramer, J., Hartmann, M., Weizel, L., Hernandez-Olmos, V., Falahati, K., Burghardt, I., Kalinchenkova, N., Bagnyukova, D., Zhurilo, N., Rautio, J., Forsberg, M., Ihalainen, J., Auriola, S., Leppänen, J., Konstantinov, I., Pogoryelov, D., Proschak, E., Dar‘in, D., Krasavin, M.
Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase (2018) Bioorganic Chemistry, 80, 655-667. http://doi.org/10.1016/j.bioorg.2018.07.014

M – O

Maltarollo, V.G., Kronenberger, T., Windshugel, B., Wrenger, C., Trossini, G.H.G., Honorio, K.M.
Advances and Challenges in Drug Design of PPARδ Ligands (2018) Curr Drug Targets. 19 (2),144-154. http://doi.org/10.2174/1389450118666170414113159

Mertens, C., Mora, J., Ören, B., Grein, S., Winslow, S., Scholich, K., Weigert, A., Malmström, P., Forsare, C., Fernö, M., Schmid, T., Brüne, B., Jung, M.
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment (2018) OncoImmunology, 7 (3), e1408751. http://doi.org/10.1080/2162402X.2017.1408751

Moreno-Cinos, C., Sassetti, E., Salado, IG., Witt, G., Benramdane, S., Reinhardt, L., Durante Cruz, C., Joossens, J., Van der Veken, P., Brotz-Oesterhelt, H., Tammela, P., Winterhalter, M., Gribbon, P., Windshügel, B., Augustyns, K.
α-Amino diphenyl phosphonates as novel inhibitors of ­Escherichia coli ClpP protease (2018) Journal of Medicinal Chemistry, American Chemical Society. Online first. http://doi.org/10.1021/acs.jmedchem.8b01466.

Nash, P., Behrens, F., Orbai, A.-M., Rathmann, S.S., Adams, D.H., Benichou, O., Deodhar, A.
Ixekizumab is efficacious when used alone or when added to conventional synthetic disease-modifying antirheumatic drugs (cDMARDs) in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor inhibitors (2018) RMD Open, 4 (2), e000692. http://doi.org/10.1136/rmdopen-2018-000692

Nothnagel, L., Wacker, M.G. How to measure release from nanosized carriers? (2018) European Journal of Pharmaceutical Sciences, 120, 199-211. http://doi.org/10.1016/j.ejps.2018.05.004

P – R

Patas, K., Willing, A., Demiralay, C., Engler, J.B., Lupu, A., Ramien, C., Schäfer, T., Gach, C., Stumm, L., Chan, K., Vignali, M., Arck, P.C., Friese, M.A., Pless, O., Wiedemann, K., Agorastos, A., Gold, S.M. T cell phenotype and T cell receptor repertoire in patients with major depressive disorder (2018) Frontiers in Immunology, 9 (FEB), art. no. 291, http://doi.org/10.3389/fimmu.2018.00291

Piña, M., Colas, P., Cancio, I., Audic, A., Bosser, L., Canario, A., Gribbon, P., Johnston, IA., Kervella, AE., Kooistra, WHCF., Merciecca, M., Magoulas, A., Nardello, I., Smith, D., Pade, N., Robinson, D., Schoen, A., Schultz, F., Kloareg, B.
The European Marine Biological Research Infrastructure Cluster: An Alliance of European Research Infrastructures to Promote the Blue Bioeconomy (2018) Grand Challenges in Marine Biotechnology, Springer, 405-421. http://doi.org/10.1007/978-3-319-69075-9_10

Pleli, T., Mondorf, A., Ferreiros, N., Thomas, D., Dvorak, K., Biondi, R.M., Heringdorf, D.M.Z., Zeuzem, S., Geißlinger, G., Zimmermann, H., Waidmann, O., Piiper, A.
Activation of adenylyl cyclase causes stimulation of adenosine receptors (2018) Cellular Physiology and Biochemistry, 45 (6), 2516-2528. http://doi.org/10.1159/000488270

Proft, F., Schulze-Koops, H., Grunke, M., Schrezenmeier, E., Halleck, F., Henes, J., Unger, L., Schmidt, E., Fiehn, C., Jacobi, A., Iking-Konert, C., Kneitz, C., Schmidt, R.E., Bannert, B., Voll, R.E., Fischer-Betz, R., Kötter, I., Tony, H.P., Holle, J., Aringer, M., Erler, A., Behrens, F., Burmester, G.R., Dörner, T.
Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy: Data from a nationwide German registry (GRAID2) [Sicherheit und Wirksamkeitshinweise zum Off-label-Einsatz von Biologikatherapien nach Versagen konventioneller Therapien bei Patienten mit entzündlich rheumatischen Erkrankungen: Ergebnisse eines nationalen Registers (GRAID2)] (2018) Zeitschrift fur Rheumatologie, 77 (1), 28-39. http://doi.org/10.1007/s00393-017-0330-4

Ringleb, J., Strack, E., Angioni, C., Geißlinger, G., Steinhilber, D., Weigert, A., Brüne, B.
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages (2018) Journal of Immunology, 200 (2), 857-868. http://doi.org/10.4049/jimmunol.1700609

Roos, J., Peters, M., Maucher, I.V., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Sommer, B., Urbschat, A., Piesche, M., Vogel, A., Proschak, E., Blöcher, R., Buscató, E., Häfner, A.-K., Matrone, C., Werz, O., Heidler, J., Wittig, I., Angioni, C., Geisslinger, G., Parnham, M.J., Zacharowski, K., Steinhilber, D., Maier, T.J. Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy (2018) Antioxidants and Redox Signaling, 28 (14), 1265-1285. http://doi.org/10.1089/ars.2017.7155

S – U

Sala, A., Proschak, E., Steinhilber, D., Rovati, G.E.
Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade (2018) Biochemical Pharmacology, 158, 161-173. http://doi.org/10.1016/j.bcp.2018.10.007

Schierle, S., Flauaus, C., Heitel, P., Willems, S., Schmidt, J., Kaiser, A., Weizel, L., Goebel, T., Kahnt, A.S., Geißlinger, G., Steinhilber, D., Wurglics, M., Rovati, G.E., Schmidtko, A., Proschak, E., Merk, D.
Boosting anti-inflammatory potency of zafirlukast by designed polypharmacology (2018) Journal of Medicinal Chemistry, 61 (13), 5758-5764. http://doi.org/10.1021/acs.jmedchem.8b00458

Sehnert, B., Burkhardt, H., Finzel, S., Dübel, S., Voll, R.E. The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways (2018) Clinical Immunology, 186,  14-20. http://doi.org/10.1016/j.clim.2017.08.018

Sekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A.F., Brüne, B., Rodriguez-Barbosa, J.I., Weigert, A. Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma (2018) International Journal of Molecular Sciences, 19 (3), art. no. 752, http://doi.org/10.3390/ijms19030752

Shiratori, H., Feinweber, C., Luckhardt, S., Wallner, N., Geisslinger, G., Weigert, A., Parnham, M.J. An in vitro test system for compounds that modulate human inflammatory macrophage polarization (2018) European Journal of Pharmacology, 833, 328-338. http://doi.org/10.1016/j.ejphar.2018.06.017

Snodgrass, R.G., Zezina, E., Namgaladze, D., Gupta, S., Angioni, C., Geißlinger, G., Lütjohann, D., Brüne, B.
A novel function for 15-Lipoxygenases in cholesterol homeostasis and CCL17 production in human macrophages. (2018) Front Immunol 1906 (9), 1-16. http://doi.org/10.3389/fimu.2018.01906

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M.
Comparative analysis of the transcriptome responses of zebrafish embryos after exposure to low concentrations of cadmium, cobalt and copper (2018) Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 25, 99-108. http://doi.org/10.1016/j.cbd.2017.12.001

Spry, C., Sewell, A.L., Hering, Y., Villa, M.V.J., Weber, J., Hobson, S.J., Harnor, S.J., Gul, S., Marquez, R., Saliba, K.J. Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation http://doi.org/10.1016/j.ejmech.2017.08.050

Stoessel, D., Stellmann, J.-P., Willing, A., Behrens, B., Rosenkranz, S.C., Hodecker, S.C., Stürner, K.H., Reinhardt, S., Fleischer, S., Deuschle, C., Maetzler, W., Berg, D., Heesen, C., Walther, D., Schauer, N., Friese, M.A., Pless, O.
Metabolomic profiles for primary progressive multiple sclerosis stratification and disease course monitoring (2018) Frontiers in Human Neuroscience, 12, 226. http://doi.org/10.3389/fnhum.2018.00226

Stürner, K.H., Stellmann, J.-P., Dörr, J., Paul, F., Friede, T., Schammler, S., Reinhardt, S., Gellissen, S., Weissflog, G., Faizy, T.D., Werz, O., Fleischer, S., Vaas, L.A.I., Herrmann, F., Pless, O., Martin, R., Heesen, C.
A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial) (2018) Journal of Neurology, Neurosurgery and Psychiatry, 89 (4), 330-338. http://doi.org/10.1136/jnnp-2017-317101

Tandon, R., Brändl, B., Baryshnikova, N., Landshammer, A., Steenpaß, L., Keminer, O., Pless, O., Müller, F.-J.
Generation of two human isogenic iPSC lines from fetal dermal fibroblasts (2018) Stem Cell Research, 33, 120-124. http://doi.org/10.1016/j.scr.2018.10.004

Thalman, C., Horta, G., Qiao, L., Endle, H., Tegeder, I., Cheng, H., Laube, G., Sigrudsson, T., Hauser, M.J., Tenzer, S., Distler, U., Aoki, J., Morris, A.J., Geißlinger, G., Röper, J., Kirischuk, S., Luhmann, H.J., Radyushkin, K., Nitsch, R., Vogt, J.
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders (2018) Molecular Psychiatry, 23 (8), 1699-1710. http://doi.org/10.1038/s41380-018-0053-1

Toewe, A., Balas, L., Durand, T., Geisslinger, G., Ferreirós, N. Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry (2018) Analytica Chimica Acta, . Article in Press. http://doi.org/10.1016/j.aca.2018.05.020

Treutlein, E.-M., Kern, K., Weigert, A., Tarighi, N., Schuh, C.-D., Nüsing, R.M., Schreiber, Y., Ferreirós, N., Brüne, B., Geißlinger, G., Pierre, S., Scholich, K.
The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage (2018) Journal of Biological Chemistry, 293 (25), 9685-9695. http://doi.org/10.1074/jbc.RA118.002492

Trillhaase, A., Haferkamp, U., Rangnau, A., Märtens, M., Schmidt, B., Trilck, M., Seibler, P., Aherrahrou, R., Erdmann, J., Aherrahrou, Z.
Differentiation of human iPSCs into VSMCs and generation of VSMC-derived calcifying vascular cells (2018) Stem Cell Research, 31, 62-70. http://doi.org/10.1016/j.scr.2018.07.008

Tunaru, S., Bonnavion, R., Brandenburger, I., Preussner, J., Thomas, D., Scholich, K., Offermanns, S.
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1 (2018) Nature Communications, 9 (1), 177. http://doi.org/10.1038/s41467-017-02539-4

Uliassi, E., Piazzi, L., Belluti, F., Mazzanti, A., Kaiser, M., Brun, R., Moraes, C.B., Freitas-Junior, L.H., Gul, S., Kuzikov, M., Ellinger, B., Borsari, C., Costi, M.P., Bolognesi, M.L.
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections (2018) ChemMedChem, 13 (7), 678-683. http://doi.org/10.1002/cmdc.201700786

V – Z

Van Vollenhoven, R.F., Keystone, E.C., Strand, V., Pacheco-Tena, C., Vencovský, J., Behrens, F., Racewicz, A., Zipp, D., Rharbaoui, F., Wolter, R., Knierim, L., Schmeidl, R., Zhou, X., Aigner, S., Dälken, B., Wartenberg-Demand, A.
Efficacy and safety of tregalizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase IIb, randomised, placebo-controlled trial (2018) Annals of the Rheumatic Diseases, 77 (4), 495-499. http://doi.org/10.1136/annrheumdis-2017-212478

Vögtle, F.-N., Brändl, B., Larson, A., Pendziwiat, M., Friederich, M.W., White, S.M., Basinger, A., Kücükköse, C., Muhle, H., Jähn, J.A., Keminer, O., Helbig, K.L., Delto, C.F., Myketin, L., Mossmann, D., Burger, N., Miyake, N., Burnett, A., van Baalen, A., Lovell, M.A., Matsumoto, N., Walsh, M., Yu, H.-C., Shinde, D.N., Stephani, U., Van Hove, J.L.K., Müller, F.-J., Helbig, I.
Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood (2018) American Journal of Human Genetics, 102 (4), 557-573. http://doi.org/10.1016/j.ajhg.2018.02.014

Vollert, J., Magerl, W., Baron, R., Binder, A., Enax-Krumova, E.K., Geißlinger, G., Gierthmuhlen, J., Henrich, F., Hullemann, P., Klein, T., Lotsch, J., Maier, C., Oertel, B., Schuh-Hofer, S., Tolle, T.R., Treede, R.-D.
Pathophysiological mechanisms of neuropathic pain: Comparison of sensory phenotypes in patients and human surrogate pain models (2018) Pain, 159 (6), 1090-1102. http://doi.org/10.1097/j.pain.0000000000001190

Wacker, M.G., Janas, C., Ferreira, F.S., Vieira, F.P.
Manufacturing and Safety Guidelines for Manufactured Functionalized Nanomaterials in Pharmaceutics (2018) Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation, 623-651. http://doi.org/10.1016/B978-0-323-50878-0.00021-5

Wegner, M.-S., Gruber, L., Mattjus, P., Geißlinger, G., Grösch, S.
The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1) (2018) BMC Cancer, 18 (1), 153. http://doi.org/10.1186/s12885-018-4084-4

Wegner, M.-S., Schömel, N., Gruber, L., Örtel, S.B., Kjellberg, M.A., Mattjus, P., Kurz, J., Trautmann, S., Peng, B., Wegner, M., Kaulich, M., Ahrends, R., Geisslinger, G., Grösch, S.
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells (2018) Cellular and Molecular Life Sciences, 75 (18), 3393-3410. http://doi.org/10.1007/s00018-018-2799-7

Weigert, A., von Knethen, A., Fuhrmann, D., Dehne, N., Brüne, B. Redox-signals and macrophage biology (for the upcoming issue of molecular aspects of medicine on signaling by reactive oxygen species) (2018) Molecular Aspects of Medicine, http://doi.org/10.1016/j.mam.2018.01.003

Weyer-Menkhoff, I., Lötsch, J.
Human pharmacological approaches to TRP-ion-channel-based analgesic drug development (2018) Drug Discovery Today, 23 (12), 2003-2012, http://doi.org/10.1016/j.drudis.2018.06.020

Weyer-Menkhoff, I., Thrun, M.C., Lötsch, J. Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects (2018) European Journal of Pain (United Kingdom), 22 (5), 862-874. http://doi.org/10.1002/ejp.1173

Winau, L., Hinojar Baydes, R., Braner, A., Drott, U., Burkhardt, H., Sangle, S., D‘Cruz, D.P., Carr-White, G., Marber, M., Schnoes, K., Arendt, C., Klingel, K., Vogl, T.J., Zeiher, A.M., Nagel, E., Puntmann, V.O.
High-sensitive troponin is associated with subclinical imaging biosignature of inflammatory cardiovascular involvement in systemic lupus erythematosus (2018) Annals of the Rheumatic Diseases, 77 (11), 1590-1598. http://doi.org/10.1136/annrheumdis-2018-213661

Windshügel, B.
Structural Insights into Ligand-Binding Pocket Formation in Nurr1 by Molecular Dynamics Simulations (2018) Journal of Biomolecular Structure and Dynamics. http://doi.org/10.1080/07391102.2018.1559099

Zezina, E., Snodgrass, R.G., Schreiber, Y., Zukunft, S., Schürmann, C., Heringdorf, D.M.Z., Geißlinger, G., Fleming, I., Brandes, R.P., Brüne, B., Namgaladze, D.
Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (4), 433-446. http://doi.org/10.1016/j.bbalip.2018.01.009

Zhong, J., Scholz, T., Yau, A.C.Y., Guerard, S., Hüffmeier, U., Burkhardt, H., Holmdahl, R.
Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes (2018) Science Advances, 4 (5), eaas9864. http://doi.org/10.1126/sciadv.aas9864

Zimmer, B., Angioni, C., Osthues, T., Toewe, A., Thomas, D., Pierre, S.C., Geisslinger, G., Scholich, K., Sisignano, M. The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (7), 669-678. http://doi.org/10.1016/j.bbalip.2018.03.012

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Behrens, F., Thaci, D., Wollenhaupt, J., Kruger, K., 2017 Psoriatic arthritis : Overview of drug therapy options and administration characteristics. Hautarzt No. 68(2): 153-169. http://doi.org/10.1007/s00105-016-3925-9

Bender, C., Christen, S., Scholich, K., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U., 2017 Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes. Diabetes (2017) No. 66(1): 113-126. http://doi.org/10.2337/db16-0547

Borsari, C., Santarem, N., Torrado, J., Olías, A.I., Corral, M.J., Baptista, C., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Witt, G., Gribbon, P., Reinshagen, J., Linciano, P., Tait, A., Costantino, L., Freitas-Junior, L.H., Moraes, C.B., Bruno dos Santos, P., Alcântara, L.M., Franco, C.H., Bertolacini, C.D., Fontana, V., Tejera Nevado, P., Clos, J., Alunda, J.M., Cordeiro-da-Silva, A., Ferrari, S., Costi, M.P., 2017. Methoxylated 2’-hydroxychalcones as antiparasitic hit compounds. European Journal of Medicinal Chemistry 126, 1129–1135. http://doi.org/10.1016/j.ejmech.2016.12.017

Dehne, N., Mora, J., Namgaladze, D., Weigert, A., Brüne, B., 2017. Cancer cell and macrophage cross-talk in the tumor microenvironment. Current Opinion in Pharmacology 35, 12–19. http://doi.org/10.1016/j.coph.2017.04.007

Di Pisa, F., Landi, G., Dello Iacono, L., Pozzi, C., Borsari, C., Ferrari, S., Santucci, M., Santarem, N., Cordeiro-Da-Silva, A., Moraes, C.B., Alcantara, L.M., Fontana, V., Freitas-Junior, L.H., Gul, S., Kuzikov, M., Behrens, B., Pöhner, I., Wade, R.C., Costi, M.P., Mangani, S., 2017. Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity. Molecules 22. http://doi.org/10.3390/molecules22030426

Dimova, V., Oertel, B.G., Lötsch, J., 2017. Using a standardized clinical quantitative sensory testing battery to judge the clinical relevance of sensory differences between adjacent body areas. Clinical Journal of Pain 33, 37–43. http://doi.org/10.1097/AJP.0000000000000372

Florian, P., Wonerow, P., Harder, S., Kuczka, K., Dubar, M., Graff, J., 2017. Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber. Eur J Clin Pharmacol 73, 949–956. http://doi.org/10.1007/s00228-017-2264-9

Fuhrmann, D.C., Brüne, B., 2017. Mitochondrial composition and function under the control of hypoxia. Redox Biology 12, 208–215. http://doi.org/10.1016/j.redox.2017.02.012

Grösch, S., Niederberger, E., Geisslinger, G., 2017. Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain. Expert Opinion on Investigational Drugs 26, 51–61. http://doi.org/10.1080/13543784.2017.1260544

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R., 2017. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos. Environ Sci Pollut Res 1–14. http://doi.org/10.1007/s11356-017-8977-6

Hohmann, S.W., Angioni, C., Tunaru, S., Lee, S., Woolf, C.J., Offermanns, S., Geisslinger, G., Scholich, K., Sisignano, M., 2017. The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Scientific Reports 7. http://doi.org/10.1038/s41598-017-00591-0

Janas, C., Mast, M.-P., Kirsamer, L., Angioni, C., Gao, F., Mäntele, W., Dressman, J., Wacker, M.G., 2017. The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers. European Journal of Pharmaceutics and Biopharmaceutics 115, 73–83. http://doi.org/10.1016/j.ejpb.2017.02.006

Jeske, J., Windshügel, B., Thasler, W.E., Schwab, M., Burk, O., 2017. Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor. Archives of Toxicology 91, 2375–2390. http://doi.org/10.1007/s00204-017-1948-3

Jung, M., Mertens, C., Bauer, R., Rehwald, C., Brüne, B., 2017a. Lipocalin-2 and iron trafficking in the tumor microenvironment. Pharmacological Research 120, 146–156. http://doi.org/10.1016/j.phrs.2017.03.018

Jung, M., Weigert, A., Mertens, C., Rehwald, C., Brüne, B., 2017b. Iron handling in tumor-associated macrophages-Is there a new role for lipocalin-2? Frontiers in Immunology 8. http://doi.org/10.3389/fimmu.2017.01171

Koch, A., Grammatikos, G., Trautmann, S., Schreiber, Y., Thomas, D., Bruns, F., Pfeilschifter, J., Badenhoop, K., Penna-Martinez, M., 2017. Vitamin D supplementation enhances C18(Dihydro)ceramide levels in type 2 diabetes patients. International Journal of Molecular Sciences 18. http://doi.org/10.3390/ijms18071532

Kringel, D., Sisignano, M., Zinn, S., Lötsch, J., 2017. Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeqTM panel. PLoS ONE 12. http://doi.org/10.1371/journal.pone.0180116

Niederberger, E., Resch, E., Parnham, M.J., Geisslinger, G., 2017. Drugging the pain epigenome. Nature Reviews Neurology 13, 434–447. http://doi.org/10.1038/nrneurol.2017.68

Oertel, S., Scholich, K., Weigert, A., Thomas, D., Schmetzer, J., Trautmann, S., Wegner, M.-S., Radeke, H.H., Filmann, N., Brüne, B., Geisslinger, G., Tegeder, I., Grösch, S., 2017. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell. Mol. Life Sci. 74, 3039–3055. http://doi.org/10.1007/s00018-017-2518-9

Parnham, M.J., 2017. Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications. Inflammation Research 66. http://doi.org/10.1007/s00011-016-0988-0

Pierre, S., Linke, B., Suo, J., Tarighi, N., Del Turco, D., Thomas, D., Ferreiros, N., Stegner, D., Frölich, S., Sisignano, M., Meyer Dos Santos, S., deBruin, N., Nüsing, R.M., Deller, T., Nieswandt, B., Geisslinger, G., Scholich, K., 2017. GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. Journal of Investigative Dermatology 137, 686–695. http://doi.org/10.1016/j.jid.2016.09.036

Rahlff, J., Peters, J., Moyano, M., Pless, O., Claussen, C., Peck, M.A., 2017. Short-term molecular and physiological responses to heat stress in neritic copepods Acartia tonsa and Eurytemora affinis. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology 203, 348–358. http://doi.org/10.1016/j.cbpa.2016.11.001

Schneider, C., Oellerich, T., Baldauf, H.-M., Schwarz, S.-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W.E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M.-L., Yakunin, A.F., Geisslinger, G., Ströbel, P., Ferreirós, N., Serve, H., Keppler, O.T., Cinatl, J., 2017. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nature Medicine 23, 250–255. http://doi.org/10.1038/nm.4255

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M., 2017. Concentration dependent transcriptome responses of zebrafish embryos after exposure to cadmium, cobalt and copper. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics 24, 29–40. http://doi.org/10.1016/j.cbd.2017.07.004

Stolz, A., Putyrski, M., Kutle, I., Huber, J., Wang, C., Major, V., Sidhu, S.S., Youle, R.J., Rogov, V.V., Dötsch, V., Ernst, A., Dikic, I., 2017. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO Journal 36, 549–564. http://doi.org/10.15252/embj.201695063

Ueck, C., Volksdorf, T., Houdek, P., Vidal-Y-Sy, S., Sehner, S., Ellinger, B., Lobmann, R., Larena-Avellaneda, A., Reinshagen, K., Ridderbusch, I., Kohrmeyer, K., Moll, I., Daniels, R., Werner, P., Merfort, I., Brandner, J.M., 2017. Comparison of in-vitro and ex-vivo wound healing assays for the investigation of diabetic wound healing and demonstration of a beneficial effect of a triterpene extract. PLoS ONE 12. http://doi.org/10.1371/journal.pone.0169028

von Delius, M., Le, C.M., Ellinger, B., Kuzikov, M., Gul, S., Dong, V.M., 2017. Synthesis and Biological Activity of Octaketides from the Cytosporone Family. Israel Journal of Chemistry 57, 975–981. http://doi.org/10.1002/ijch.201700023

Wobst, I., Ebert, L., Birod, K., Wegner, M.-S., Hoffmann, M., Thomas, D., Angioni, C., Parnham, M.J., Steinhilber, D., Tegeder, I., Geisslinger, G., Grösch, S., 2017. R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4. International Journal of Molecular Sciences 18. http://doi.org/10.3390/ijms18010068

Zinn, S., Sisignano, M., Kern, K., Pierre, S., Tunaru, S., Jordan, H., Suo, J., Treutlein, E.-M., Angioni, C., Ferreiros, N., Leffler, A., Debruin, N., Offermanns, S., Geisslinger, G., Scholich, K., 2017. The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. Journal of Biological Chemistry 292, 6123–6134. http://doi.org/10.1074/jbc.M116.769125

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A - C

Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, Bernal- Delgado E. et al.: Making sense of big data in health research: Towards an EU action plan. Genome Medicine (2016) No.8(1): 71 (http://doi.org/10.1186/s13073-016-0323-y)

Aygören-Pürsün, E., Magerl, M., Graff, J., Martinez-Saguer, I., Kreuz, W., Longhurst, H., Nasr, I., Bas, M., Straßen, U., Fang, L., Cornpropst, M., Dobo, S., Collis, P., Sheridan, W.P., Maurer, M.: Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. The Journal of Allergy Clinical Immunology (2016) pii: S0091-6749(16)30270-6 (http://doi.org/10.1016/j.jaci.2016.03.043)

Barthelmes, J., Tafferner, N., Kurz, J., de Bruin, N., Parnham, M.J., Geisslinger, G., Schiffmann, S.: Induction of experimental autoimmune encephalomyelitis in mice and evaluation of the disease-dependent distribution of immune cells in various tissues. Journal of visualized experiments: JoVE. Online resource 2016 (2016) No. 111 (http://doi.org/10.3791/53933)

Behrens, F., Koehm, M., Thaci, D., Gnann, H., Greger, G., Wittig, B.M., Burkhardt, H.: Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis. Rheumatology 55 (2016) No. 10: 1791- 1795 (http://doi.org/10.1093/rheumatology/kew229)

Behrens, F., Koehm, M., Arndt, U., Wittig, B.M., Greger, G., Thaci, D., Scharbatke, E., Tony, H.-P., Burkhardt, H.: Does concomitant methotrexate with Progadalimumab influence treatment outcomes in patients with psoriatic arthritis? Data from a large observational study. The Journal of Rheumatology 43 (2016) No. 3: 632-639 (http://doi.org/10.3899/jrheum.141596)

Behrens, F., Thaci, D., Wollenhaupt, J., Krüger, K.: Psoriasisarthritis: Übersicht medikamentöser Therapieoptionen und Anwendungsbesonderheiten. Zeitschrift für Rheumatologie 75 (2016) No. 5, 471-488 (http://doi.org/10.1007/s00393-016-0110-6)

Beyer, S., Xie, L., Schmidt, M., de Bruin, N., Ashtikar, M., Rüschenbaum, S., Lange, C.M., Vogel, V.; Mäntele, W., Parnham, M.J., Wacker, M.G.: Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques. Journal of controlled release 235 (2016), 352-364 (http://doi.org/10.1016/j.jconrel.2016.06.013)

Blöcher, R., Lamers, C., Wittmann, S.K., Merk, D., Hartmann, M., Weizel, L., Diehl, O., Brüggerhoff, A., Boss, M., Kaiser, A., Schader, T., Gobel, T., Grundmann, M., Angioni, C., Heering, J., Geisslinger, G., Wurglics, M., Kostenis, E., Brüne, B., Steinhilber, D., Schubert-Zsilavecz, M., Kahnt, A.S., Proschak, E.: N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators. Journal of medicinal chemistry 59 (2016) No. 1: 61-81 (http://doi.org/10.1021/acs.jmedchem.5b01239)

Bodewein, L., Schmelter, F., Di Fiore, S., Hollert, H., Fischer, R., Fenske, M.: Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines. Toxicology and Applied Pharmacology 305 (2016) 83-92 (http://doi.org/10.1016/j.taap.2016.06.008)

Borsari, C., Luciani, R., Pozzi, C., Poehner, I., Henrich, S., Trande, M., Cordeiro-da- Silva, A., Santarem, N., Baptista, C., Tait, A., Di Pisa, F., Dello Iacono, L., Landi, G., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Gribbon, P., Kohler, M., Keminer, O., Behrens, B., Costantino, L., Tejera Nevado, P., Bifeld, E., Eick, J., Clos, J., Torrado, J., Jiménez- Antón, M.D., Corral, M.J., Alunda, J.M., Pellati, F., Wade, R.C., Ferrari, S., Mangani, S., Costi, M.P.: Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs. Journal of Medicinal Chemistry (2016) No. 59(16): 7598-7616 (http://doi.org/10.1021/acs.jmedchem.6b00698)

Boß, M., Newbatt, Y., Gupta, S., Collins, I., Brüne, B., Namgaladze, D.: AMPK-independent inhibition of human macrophage ER stress response by AICAR. Scientific Reports 6 (2016), Art. 32111, 10 (http://doi.org/10.1038/srep32111)

Brändl, B., Schuldt, B.M., Böhnke, L., Keminer, O., Vaas, L.A.I., Fischer, R., Müller, F.J., Pless, O.: Utilizing regulatory networks for pluripotency assessment in stem cells. Current Stem Cell Reports (2016), No. 2(3): 228-235. Review. (http://dx.doi.org/10.1007%2Fs40778-016-0054-4)

Brenke, J.K., Salmina, E.S., Ringelstetter, L., Dornauer, S., Kuzikov, M., Rothenaigner, I., Schorpp, K., Giehler, F., Gopalakrishnan, J., Kieser, A., Gul, S., Tetko, I.V., Hadian, K.: Identification of small-molecule frequent hitters of glutathione s-transferase- glutathione interaction. Journal of Biomolecular Screening 21 (2016) No.6: 596-607 (http://doi.org/10.1177/1087057116639992)

Brenneis, M., Aghajaanpour, R., Knape, T., Sha, L.K., Neb, H., Meybohm, P., Zacharowski, K., Hauser, I.A., Buttner, S., Parnham, M.J., Brune, B., Von Knethen, A.: Pparg Expression in T Cells as a Prognostic Marker of Sepsis. Shock 45 (2016), No. 6: 591-597 (http://doi.org/10.1097/SHK.0000000000000568)

Briken, S., Rosenkranz, S.C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Hellweg, R., Pless, O., Schulz, K.H., Gold, S.M.: Effects of exercise on irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of Neuroimmunology (2016) No. 299: 53-58 (http://doi.org/10.1016/j.jneuroim.2016.08.007)

Brüne, B., Courtial, N., Dehne, N., Syed, S.N., Weigert, A.: Macrophage NOS2 in tumor leukocytes. Antioxidants & Redox Signaling. [Epub ahead of print] (http://doi.org/10.1089/ars.2016.6811)

Bruin, N.M.W.J. de, Schmitz, K., Schiffmann, S., Tafferner, N., Schmidt, M., Jordan, H., Häußler, A., Tegeder, I., Geisslinger, G., Parnham, M.J.: Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behavioural Brain Research 300 (2016) 160-174 (http://doi.org/10.1016/j.bbr.2015.12.006)

Bruin de, N.M.W.J., van Loevezijn, A., Wicke, K.M., de Haan, M., Venhorst, J., Lange, J.H.M., de Groote, L., van der Neut, M.A.W., Prickaerts, J., Andriambeloson, E., Foley, A.G., van Drimmelen, M., van der Wetering, M., Kruse, C.G.: The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment. Neurobiology of Learning and Memory (2016) No. 133: 100–117 (http://doi.org/10.1016/j.nlm.2016.06.020) )

Budu-Aggrey, A., Bowes, J. Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., Fitzgerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A.; Barton, A.: Replication of a distinct psoriatic arthritis risk variant at the IL23R locus. Annals of the rheumatic diseases 75 (2016) No. 7: 1417-1418 (http://doi.org/10.1136/annrheumdis-2016-209290)

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Burkhardt, H., Weisenseel, P., Radtke, M.A., Krüger, K.: Hautmalignome und immunmodulierende Antirheumatikatherapie. Zeitschrift für Rheumatologie 75 (2016), No. 1: 32-40 (http://doi.org/10.1007/s00393-015-0037-3)

Capelo, R., Lehmann, C., Ahmad, K., Snodgrass, R., Diehl, O., Ringleb, J., Flamand, N., Weigert, A., Stark, H., Steinhilber, D., Kahnt, A.S.: Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochemical pharmacology 103 (2016) 74-84 (http://doi.org/10.1016/j.bcp.2016.01.007)

Combe, B., Behrens, F., McHugh, N., Brock, F., Kerkmann, U., Kola, B., Gallo, G.: Comparison of etanercept monotherapy and combination therapy with methotrexate in psoriatic arthritis: Results from 2 clinical trials. The Journal of Rheumatology 43 (2016) No. 6: 1063-1067 (http://doi.org/10.3899/jrheum.151290)

 

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Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Finl, A.F., Roberts, E., Brüne, B., Weigert, A.: S1PR4 signaling attenuates ILT7 internalization to limit IFN-a production by human plasmacytoid dendritic cells. The Journal of Immunology (2016) No. 196 (4): 1579-1590 (http://doi.org/10.4049/jimmunol.1403168)

Drebes, J., Künz, M., Windshügel, B., Kikhney, A.G., Müller, I.B., Eberle, R.J., Oberthür, D., Cang, H., Svergun, D.I., Perbandt, M., Betzel, C., Wrenger, C.: Structure of ThiM from vitamin B1 biosynthetic pathway of Staphylococcus aureus – insights into a novel pro-drug approach addressing MRSA infections. Scientific Reports (2016) No. 6: 22871 (http://doi.org/10.1038/srep22871)

Ellinger, B., Gribbon P.: Risk mitigation in academic drug discovery. Expert Opinion on Drug Discovery (2016) No. 133(4): 333-336 (http://doi.org/10.1517/17460441.2016.1152257)

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Frenz, T., Grabski, E., Buschjäger, D., Vaas, L.A., Burgdorf, N., Schmidt, R.E., Witte, T., Kalinke, U.: CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. The Journal of Allergy Clinical Immunology (2016) No. 138(2): 586-589.e10 (http://doi.org/10.1016/j.jaci.2016.04.013)

 

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Hauser, A.S., Windshügel, B.: LEADS-PEP: A benchmark data set for assessment of peptide docking performance. Journal of Chemical Information and Modeling 2016 Jan 25; No. 56(1): 188- 200 (http://doi.org/10.1021/acs.jcim.5b00234)

Henke, N., Ferreiros, N., Geisslinger, G., Ding, M. G., Essler, S., Fuhrmann, D. C., Geis, T., Namgaladze, D., Dehne, N., Brune, B.: Loss of HIF-1alpha in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model. Oncotarget 7 (2016) No. 18: 25915-29 (http://doi.org/10.18632/oncotarget.8297)

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Kemmerer, M., Wittig, I., Richter, F., Brüne, B., Namgaladze, D.: AMPK activates LXRa and ABCA1 expression in human macrophages. The International Journal of Biochemistry & Cell Biology (2016) No. 78: 1-9 (http://doi.org/10.1016/j.biocel.2016.06.014)

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Klingler, F.M., Wolf, M., Wittmann, S., Gribbon, P., Proschak, E.: Bacterial expression and HTS assessment of soluble epoxide hydrolase phosphatase. Journal of Biomolecular Screening (2016) No. 7: 689-94 (http://doi.org/10.1177/1087057116637609)

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Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G., Schachner, M.: Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions. Journal of Neurochemistry (2016) No. 136(1): 48-62 (http://doi.org/10.1111/jnc.13383)

Loevezijn van, A., Venhorst, J., Iwema Bakker, W.I., Lange, J.H.M., de Looff, W., Henzen, R., de Vries, J., van de Woestijne, R.P., den Hartog, A.P., Verhoog, S., van der Neut, M.A.W., de Bruin, N.M.W.J., Kruse, C.G.: Optimization of N’-(arylsulfonyl) pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket. Bioorganic & Medicinal Chemistry Letters (2016), No. 26: 1605–1611 (http://doi.org/ 10.1016/j.bmcl.2016.02.001)

Lötsch, J., Ultsch, A.: A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes. Integrative Biology 8 (2016) No. 1: 91-103 (http://doi.org/10.1039/c5ib00203f)

Lötsch, J., Ultsch, A., Hummel, T.: How many and which odor identification items are needed to establish normal olfactory function? Chemical Senses 41 (2016) No. 4: 339-344 (http://doi.org/10.1093/chemse/bjw006)

Lötsch, J., Ultsch, A.: A machine-learned computational functional genomics-based approach to drug classification. European Journal of Clinical Pharmacology 72 (2016), No. 12: 1449-1461 (http://doi.org/10.1007/s00228-016-2134-x)

Lötsch, J., Ultsch, A.: Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy. CPT. Pharmacometrics & Systems Pharmacology 5 (2016), No. 4: 192-200 (http://doi.org/10.1002/psp4.12072)

Lötsch, J., Dimova, V., Ultsch, A., Lieb, I., Zimmermann, M., Geisslinger, G., Oertel, B.G.: A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects. European Journal of Pain: EJP 20 (2016) No. 5: 777-789 (http://doi.org/10.1002/ejp.803)

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Maculins, T., Fiskin, E., Bhogaraju, S., Dikic, I.: Bacteria-host relationship: Ubiquitin ligases as weapons of invasion. Cell Research 26 (2016) No. 4: 499-510 (http://doi.org/10.1038/cr.2016.30)

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Meirer, K., Glatzel, D., Kretschmer, S., Wittmann, S. K., Hartmann, M., Blocher, R., Angioni, C., Geisslinger, G., Steinhilber, D., Hofmann, B., Furst, R., Proschak, E.: Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase. Molecules 22 (2016) No. 1 (http://doi.org/10.3390/molecules22010045)

Moll, J., Meyer dos Santos, S., Hils, B., Dornuf, F., Rodrigues Meyer dos Santos, I., Singer, O.C., Ferreiros, N., Labocha, S., Blücher, A., Harder, S., Krozer, V.: Micro-optical prototyping of a surface acoustic wave-based point-of-care coagulation assay and first application in anticoagulated patients. International Journal of Clinical Pharmacology and Therapeutics 54 (2016) No. 3: 177-184 (http://doi.org/10.5414/CP202492)

Mora, J., Schlemmer, A., Wittig, I., Richter, F., Putyrski, M., Frank, A.-C., Han, Y., Jung, M., Ernst, A., Weigert, A., Brüne, B.: Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol 8 (2016), 426–438. (http://doi.org/10.1093/jmcb/mjw006)

Möser, C.V., Meissner, M., Laarmann, K., Olbrich, K., King-Himmelreich, T.S., Wolters, M.C., Geisslinger, G., Niederberger, E.: The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. Biochemical Pharmacology 103 (2016), 64-73 (http://doi.org/10.1016/j.bcp.2015.12.016)

Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Baumann, L., Schäfers, C., Teigeler, M., Fenske, M.: Corrigendum to „Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test“. [Aquat. Toxicol. 176 (2016) 116-127] Aquatic Toxicology 177 (2016) 536 (http://doi.org/10.1016/j.aquatox.2016.05.010)

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Parnham, M.J. (Ed.): Compendium of Inflammatory Diseases. Springer, Basel (2016). ISBN: 978-3- 0348-0620-6 (DOI 10.1007/978-3-7643-8550-7; http://doi.org/10.1007/978-3-0348-0620-6)

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Samir, M., Vaas, L.A., Pessler, F.: MicroRNAs in the host response to viral infections of veterinary importance. Frontiers in Veterinary Science (2016) No. 3: 86 (http://doi.org/10.3389/fvets.2016.00086)

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Schröder, M., Kolodzik, A., Windshügel, B., Krepstakies, M., Priyadarshini, P., Hartjen, P., van Lunzen, J., Rarey, M., Hauber, J., Meier, C.: Linker-region modified derivatives of the deoxyhypusine synthase inhibitor CNI-1493 suppress HIV-1 replication. Archiv der Pharmazie (Weinheim) (2016) No. 349(2): 91-103. (http://doi.org/10.1002/ardp.201500323)

Shiratori, H., Feinweber, C., Knothe, C., Lötsch, J., Geisslinger, G., Parnham, M.J., Resch, E.: High-throughput analysis of global DNA methylation using methyl sensitive digestion. PLOS ONE. Online journal 11(10): e0163184 (2016)  (http://doi.org/10.1371/journal.pone.0163184)

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Sisignano, M., Parnham, M.J., Geisslinger, G.: Drug repurposing for the development of novel analgesics. Trends in Pharmacological Sciences 37 (2016)172-83 (http://dx.doi.org/10.1016%2Fj.tips.2015.11.006)

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Walter, C., Knothe, C., Lötsch, J.: Abuse-deterrent opioid formulations: pharmacokinetic and pharmacodynamic considerations. Clinical pharmacokinetics 55 (2016) No. 7, 751-767 (http://doi.org/10.1007/s40262-015-0362-3)

Walter, C., Oertel, B.G., Felden, L., Kell, C.A., Nöth, U., Vermehren, J., Kaiser, J., Deichmann, R., Lötsch, J.: Brain mapping-based Model of D(9)-tetrahydrocannabinol effects on connectivity in the pain matrix. Neuropsychopharmacology. 2016 May;41(6):1659-69 (http://doi.org/10.1038/npp.2015.336)

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