Veröffentlichungen Translationale Medizin

A - C

Annak, O., Heidegger, T., Walter, C., Deichmann, R., Nöth, U., Hansen-Goos, O., Ziemann, U., Lötsch, J.
Effects of continuous theta-burst stimulation of the primary motor and secondary somatosensory areas on the central processing and the perception of trigeminal nociceptive input in healthy volunteers (2019) Pain, 160 (1), 172–186. http://doi.org/10.1097/j.pain.0000000000001393

Astakhova, A., Chistyakov, D., Thomas, D., Geisslinger, G., Brüne, B., Sergeeva, M., Namgaladze, D.
Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization (2019) Cells, 8 (10). http://doi.org/10.3390/cells8101185

Bärnthaler, T., Jandl, K., Sill, H., Uhl, B., Schreiber, Y., Grill, M., Thomas, D., Schicho, R., Marsche, G., Frank, S., Heinemann, A., Schuligoi, R.
Imatinib stimulates prostaglandin E2 and attenuates cytokine release via EP4 receptor activation (2019) The Journal of allergy and clinical immunology, 143 (2), 794-797.e10. http://doi.org/10.1016/j.jaci.2018.09.030

Bazarganipour, S., Hausmann, J., Oertel, S., El-Hindi, K., Brachtendorf, S., Blumenstein, I., Kubesch, A., Sprinzl, K., Birod, K., Hahnefeld, L., Trautmann, S., Thomas, D., Herrmann, E., Geisslinger, G., Schiffmann, S., Grösch, S.
The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated (2019) Journal of clinical medicine, 8 (7). http://doi.org/10.3390/jcm8070971

Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Use of a "critical difference" statistical criterion improves the predictive utility of the Health Assessment Questionnaire-Disability Index score in patients with rheumatoid arthritis (2019) BMC rheumatology, 3, 51. http://doi.org/10.1186/s41927-019-0095-2

Behrens, F., Köhm, M., Schwaneck, E.C., Schmalzing, M., Wittig, B.M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Addition or removal of concomitant methotrexate alters adalimumab effectiveness in rheumatoid arthritis but not psoriatic arthritis (2019) Scandinavian journal of rheumatology, 48 (5), 375–382. http://doi.org/10.1080/03009742.2019.1600717

Berben, P., Ashworth, L., Beato, S., Bevernage, J., Bruel, J.-L., Butler, J., Dressman, J.B., Schäfer, K., Hutchins, P., Klumpp, L., Mann, J., Nicolai, J., Ojala, K., Patel, S., Powell, S., Rosenblatt, K., Tomaszewska, I., Williams, J., Augustijns, P.
Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 140, 141–148. http://doi.org/10.1016/j.ejpb.2019.04.017

Bhaskara, R.M., Grumati, P., Garcia-Pardo, J., Kalayil, S., Covarrubias-Pinto, A., Chen, W., Kudryashev, M., Dikic, I., Hummer, G.
Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy (2019) Nature communications, 10 (1), 2370. http://doi.org/10.1038/s41467-019-10345-3

Bhogaraju, S., Bonn, F., Mukherjee, R., Adams, M., Pfleiderer, M.M., Galej, W.P., Matkovic, V., Lopez-Mosqueda, J., Kalayil, S., Shin, D., Dikic, I.
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation (2019) Nature, 572 (7769), 382–386. http://doi.org/10.1038/s41586-019-1440-8

Bode, E., Heinrich, A.K., Hirschmann, M., Abebew, D., Shi, Y.-N., Vo, T.D., Wesche, F., Shi, Y.-M., Grün, P., Simonyi, S., Keller, N., Engel, Y., Wenski, S., Bennet, R., Beyer, S., Bischoff, I., Buaya, A., Brandt, S., Cakmak, I., Çimen, H., Eckstein, S., Frank, D., Fürst, R., Gand, M., Geisslinger, G., Hazir, S., Henke, M., Heermann, R., Lecaudey, V., Schäfer, W., Schiffmann, S., Schüffler, A., Schwenk, R., Skaljac, M., Thines, E., Thines, M., Ulshöfer, T., Vilcinskas, A., Wichelhaus, T.A., Bode, H.B.
Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing (2019) Angewandte Chemie (International ed. in English), 58 (52), 18957–18963. http://doi.org/10.1002/anie.201910563

Borsari, C., Jiménez-Antón, M.D., Eick, J., Bifeld, E., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Santarem, N., Baptista, C., Severi, L., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Linciano, P., Tait, A., Costantino, L., Luciani, R., Tejera Nevado, P., Zander-Dinse, D., Franco, C.H., Ferrari, S., Moraes, C.B., Cordeiro-da-Silva, A., Ponterini, G., Clos, J., Alunda, J.M., Costi, M.P.
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics (2019) European journal of medicinal chemistry, 183, 111676. http://doi.org/10.1016/j.ejmech.2019.111676

Borsari, C., Santarem, N., Macedo, S., Jiménez-Antón, M.D., Torrado, J.J., Olías-Molero, A.I., Corral, M.J., Tait, A., Ferrari, S., Costantino, L., Luciani, R., Ponterini, G., Gul, S., Kuzikov, M., Ellinger, B., Behrens, B., Reinshagen, J., Alunda, J.M., Cordeiro-da-Silva, A., Costi, M.P.
SAR Studies and Biological Characterization of a Chromen-4-one Derivative as an Anti-Trypanosoma brucei Agent (2019) ACS medicinal chemistry letters, 10 (4), 528–533. http://doi.org/10.1021/acsmedchemlett.8b00565

Braun, J., Schwarting, A., Hammel, L., Legeler, C., Wimmer, P., Färber, L., Behrens, F.
Versorgungssituation von Patienten mit ankylosierender Spondylitis und Psoriasisarthritis in Deutschland : Versorgungssituation von Patienten mit Spondyloarthritis (SpA): Ankylosierende Spondylitis (AS) und Psoriasisarthritis (PsA) aus der Sicht von niedergelassenen und in Kliniken tätigen Rheumatologen in Deutschland – Ergebnisse des Forschungsprojekts „SpA Loop – Life of Outpatients“ (2019) Zeitschrift fur Rheumatologie, 78 (4), 372–381. http://doi.org/10.1007/s00393-019-0619-6

Brennecke, P., Rasina, D., Aubi, O., Herzog, K., Landskron, J., Cautain, B., Vicente, F., Quintana, J., Mestres, J., Stechmann, B., Ellinger, B., Brea, J., Kolanowski, J.L., Pilarski, R., Orzaez, M., Pineda-Lucena, A., Laraia, L., Nami, F., Zielenkiewicz, P., Paruch, K., Hansen, E., Kries, J.P. von, Neuenschwander, M., Specker, E., Bartunek, P., Simova, S., Leśnikowski, Z., Krauss, S., Lehtiö, L., Bilitewski, U., Brönstrup, M., Taskén, K., Jirgensons, A., Lickert, H., Clausen, M.H., Andersen, J.H., Vicent, M.J., Genilloud, O., Martinez, A., Nazaré, M., Fecke, W., Gribbon, P.
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology (2019) SLAS discovery : advancing life sciences R & D, 24 (3), 398–413. http://doi.org/10.1177/2472555218816276

Brunkhorst-Kanaan, N., Klatt-Schreiner, K., Hackel, J., Schröter, K., Trautmann, S., Hahnefeld, L., Wicker, S., Reif, A., Thomas, D., Geisslinger, G., Kittel-Schneider, S., Tegeder, I.
Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder (2019) Metabolism: clinical and experimental, 95, 65–76. http://doi.org/10.1016/j.metabol.2019.04.002

Chen, C., Kramer, J.S., Brunst, S., Proschak, E., Scriba, G.K.E.
Capillary electrophoresis-based enzyme assays for β-lactamase enzymes (2019) Electrophoresis, 40 (18-19), 2375–2381. http://doi.org/10.1002/elps.201900104

Choy, E., Baraliakos, X., Behrens, F., D'Angelo, S., Vlam, K. de, Kirkham, B.W., Østergaard, M., Schett, G.A., Rissler, M., Chaouche-Teyara, K., Perella, C.
The need for comparative data in spondyloarthritis (2019) Arthritis research & therapy, 21 (1), 32. http://doi.org/10.1186/s13075-019-1812-3

Cristofoletti, R., Hens, B., Patel, N., Esteban, V.V., Schmidt, S., Dressman, J.B.
Integrating Drug- and Formulation-Related Properties With Gastrointestinal Tract Variability Using a Product-Specific Particle Size Approach: Case Example Ibuprofen (2019) Journal of pharmaceutical sciences, 108 (12), 3842–3847. http://doi.org/10.1016/j.xphs.2019.09.012

D – F

Dauth, S., Köhm, M., Behrens, F.
Psoriatic arthritis: combinational therapy of biologics and methotrexate - What do we know? (2019) Clinical Trials in Degenerative Diseases, 4 (4), 0. http://doi.org/10.4103/2542-3975.274078

Deutschmann, J., Schneider, A., Gruska, I., Vetter, B., Thomas, D., Kießling, M., Wittmann, S., Herrmann, A., Schindler, M., Milbradt, J., Ferreirós, N., Winkler, T.H., Wiebusch, L., Gramberg, T.
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1 (2019) Nature microbiology, 4 (12), 2273–2284. http://doi.org/10.1038/s41564-019-0529-z

Ditzinger, F., Price, D.J., Nair, A., Becker-Baldus, J., Glaubitz, C., Dressman, J.B., Saal, C., Kuentz, M.
Opportunities for Successful Stabilization of Poor Glass-Forming Drugs: A Stability-Based Comparison of Mesoporous Silica Versus Hot Melt Extrusion Technologies (2019) Pharmaceutics, 11 (11). http://doi.org/10.3390/pharmaceutics11110577

Dreis, C., Ottenlinger, F.M., Putyrski, M., Ernst, A., Huhn, M., Schmidt, K.G., Pfeilschifter, J.M., Radeke, H.H.
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs (2019) Frontiers in immunology, 10, 1698. http://doi.org/10.3389/fimmu.2019.01698

Dufrusine, B., Di Francesco, A., Oddi, S., Scipioni, L., Angelucci, C.B., D'Addario, C., Serafini, M., Häfner, A.-K., Steinhilber, D., Maccarrone, M., Dainese, E.
Iron-Dependent Trafficking of 5-Lipoxygenase and Impact on Human Macrophage Activation (2019) Frontiers in immunology, 10, 1347. http://doi.org/10.3389/fimmu.2019.01347

Ehrnhoefer, D.E., Skotte, N.H., Reinshagen, J., Qiu, X., Windshügel, B., Jaishankar, P., Ladha, S., Petina, O., Khankischpur, M., Nguyen, Y.T.N., Caron, N.S., Razeto, A., Meyer Zu Rheda, M., Deng, Y., Huynh, K.T., Wittig, I., Gribbon, P., Renslo, A.R., Geffken, D., Gul, S., Hayden, M.R.
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound (2019) Cell chemical biology, 26 (9), 1295-1305.e6. http://doi.org/10.1016/j.chembiol.2019.07.001

Elwakeel, E., Brüggemann, M., Fink, A.F., Schulz, M.H., Schmid, T., Savai, R., Brüne, B., Zarnack, K., Weigert, A.
Phenotypic Plasticity of Fibroblasts during Mammary Carcinoma Development (2019) International journal of molecular sciences, 20 (18). http://doi.org/10.3390/ijms20184438

Elzahhar, P.A., Alaaeddine, R., Ibrahim, T.M., Nassra, R., Ismail, A., Chua, B.S.K., Frkic, R.L., Bruning, J.B., Wallner, N., Knape, T., von Knethen, A., Labib, H., El-Yazbi, A.F., Belal, A.S.F.
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones (2019) European journal of medicinal chemistry, 167, 562–582. http://doi.org/10.1016/j.ejmech.2019.02.034

Englbrecht, M., Alten, R., Aringer, M., Baerwald, C.G., Burkhardt, H., Eby, N., Flacke, J.-P., Fliedner, G., Henkemeier, U., Hofmann, M.W., Kleinert, S., Kneitz, C., Krüger, K., Pohl, C., Schett, G.A., Schmalzing, M., Tausche, A.-K., Tony, H.-P., Wendler, J.
New insights into the prevalence of depressive symptoms and depression in rheumatoid arthritis - Implications from the prospective multicenter VADERA II study (2019) PloS one, 14 (5), e0217412. http://doi.org/10.1371/journal.pone.0217412

Feczkó, T., Piiper, A., Ansar, S., Blixt, F.W., Ashtikar, M., Schiffmann, S., Ulshöfer, T., Parnham, M.J., Harel, Y., Israel, L.L., Lellouche, J.-P., Wacker, M.G.
Stimulating brain recovery after stroke using theranostic albumin nanocarriers loaded with nerve growth factor in combination therapy (2019) Journal of controlled release : official journal of the Controlled Release Society, 293, 63–72. http://doi.org/10.1016/j.jconrel.2018.11.017

Fettel, J., Kühn, B., Guillen, N.A., Sürün, D., Peters, M., Bauer, R., Angioni, C., Geisslinger, G., Schnütgen, F., Meyer Zu Heringdorf, D., Werz, O., Meybohm, P., Zacharowski, K., Steinhilber, D., Roos, J., Maier, T.J.
Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity (2019) FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33 (2), 1711–1726. http://doi.org/10.1096/fj.201800221R

Fuhrmann, D.C., Olesch, C., Kurrle, N., Schnütgen, F., Zukunft, S., Fleming, I., Brüne, B.
Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins (2019) Cells, 8 (2). http://doi.org/10.3390/cells8020172

G – I

Göbel, T., Diehl, O., Heering, J., Merk, D., Angioni, C., Wittmann, S.K., La Buscato, E., Kottke, R., Weizel, L., Schader, T., Maier, T.J., Geisslinger, G., Schubert-Zsilavecz, M., Steinhilber, D., Proschak, E., Kahnt, A.S.
Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ (2019) Frontiers in pharmacology, 10, 263. http://doi.org/10.3389/fphar.2019.00263

Grill, M., Högenauer, C., Blesl, A., Haybaeck, J., Golob-Schwarzl, N., Ferreirós, N., Thomas, D., Gurke, R., Trötzmüller, M., Köfeler, H.C., Gallé, B., Schicho, R.
Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer (2019) Scientific reports, 9 (1), 2358. http://doi.org/10.1038/s41598-019-38865-4

Gul, S.
Key concepts in assay development, screening and the properties of lead and candidate compounds (2019) In Medicinal Chemistry of Neglected and Tropical Diseases, 1-18. CRC Press. http://doi.org/10.1201/9781351011655

Gurke, R., Etyemez, S., Prvulovic, D., Thomas, D., Fleck, S.C., Reif, A., Geisslinger, G., Lötsch, J.
A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia (2019) Frontiers in psychiatry, 10, 41. http://doi.org/10.3389/fpsyt.2019.00041

Gurke, R., Schmidt, D., Thomas, D., Fleck, S.C., Geisslinger, G., Ferreirós, N.
A validated LC-MS/MS method for the determination of homocysteic acid in biological samples (2019) Journal of pharmaceutical and biomedical analysis, 174, 578–587. http://doi.org/10.1016/j.jpba.2019.06.008

Gurke, R., Thomas, D., Schreiber, Y., Schäfer, S.M.G., Fleck, S.C., Geisslinger, G., Ferreirós, N.
Determination of endocannabinoids and endocannabinoid-like substances in human K3EDTA plasma - LC-MS/MS method validation and pre-analytical characteristics (2019) Talanta, 204, 386–394. http://doi.org/10.1016/j.talanta.2019.06.004

Häfner, A.-K., Kahnt, A.S., Steinhilber, D.
Beyond leukotriene formation-The noncanonical functions of 5-lipoxygenase (2019) Prostaglandins & other lipid mediators, 142, 24–32. http://doi.org/10.1016/j.prostaglandins.2019.03.003

Han, Y., Mora, J., Huard, A., da Silva, P., Wiechmann, S., Putyrski, M., Schuster, C., Elwakeel, E., Lang, G., Scholz, A., Scholz, T., Schmid, T., de Bruin, N., Billuart, P., Sala, C., Burkhardt, H., Parnham, M.J., Ernst, A., Brüne, B., Weigert, A.
IL-38 Ameliorates Skin Inflammation and Limits IL-17 Production from γδ T Cells (2019) Cell reports, 27 (3), 835-846.e5. http://doi.org/10.1016/j.celrep.2019.03.082

Harder, S., Meyer Dos Santos, S., Krozer, V., Moll, J.
Surface Acoustic Wave-Based Microfluidic Coagulation Device for Monitoring Anticoagulant Therapy (2019) Seminars in thrombosis and hemostasis, 45 (3), 253–258. http://doi.org/10.1055/s-0038-1676318

Hardt, S., Fischer, C., Vogel, A., Wilken-Schmitz, A., Tegeder, I.
Distal infraorbital nerve injury: a model for persistent facial pain in mice (2019) Pain, 160 (6), 1431–1447. http://doi.org/10.1097/j.pain.0000000000001518

Heering, J., Merk, D.
Hybrid Reporter Gene Assays: Versatile In Vitro Tools to Characterize Nuclear Receptor Modulators (2019) Methods in molecular biology (Clifton, N.J.), 1966, 175–192. http://doi.org/10.1007/978-1-4939-9195-2_14

Heine, P., Witt, G., Gilardi, A., Gribbon, P., Kummer, L., Plückthun, A.
High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor (2019) SLAS discovery : advancing life sciences R & D, 24 (9), 915–927. http://doi.org/10.1177/2472555219837344

Heitel, P., Gellrich, L., Kalinowsky, L., Heering, J., Kaiser, A., Ohrndorf, J., Proschak, E., Merk, D.
Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype (2019) ACS medicinal chemistry letters, 10 (2), 203–208. http://doi.org/10.1021/acsmedchemlett.8b00551

Hernández-Olmos, V., Knape, T., Heering, J., von Knethen, A., Kilu, W., Kaiser, A., Wurglics, M., Helmstädter, M., Merk, D., Schubert-Zsilavecz, M., Parnham, M.J., Steinhilber, D., Proschak, E.
Structure optimization of a new class of PPARγ antagonists (2019) Bioorganic & medicinal chemistry, 27 (21), 115082. http://doi.org/10.1016/j.bmc.2019.115082

Hiesinger, K., Kramer, J.S., Achenbach, J., Moser, D., Weber, J., Wittmann, S.K., Morisseau, C., Angioni, C., Geisslinger, G., Kahnt, A.S., Kaiser, A., Proschak, A., Steinhilber, D., Pogoryelov, D., Wagner, K.M., Hammock, B.D., Proschak, E.
Computer-Aided Selective Optimization of Side Activities of Talinolol (2019) ACS medicinal chemistry letters, 10 (6), 899–903. http://doi.org/10.1021/acsmedchemlett.9b00075

Hiesinger, K., Wagner, K.M., Hammock, B.D., Proschak, E., Hwang, S.H.
Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity (2019) Prostaglandins & other lipid mediators, 140, 31–39. http://doi.org/10.1016/j.prostaglandins.2018.12.003

Hübner, C.A., Dikic, I.
ER-phagy and human diseases (2019) Cell death and differentiation . http://doi.org/10.1038/s41418-019-0444-0

J – L

Jablonka, L., Ashtikar, M., Gao, G.F., Jung, F., Thurn, M., Preuß, A., Scheglmann, D., Albrecht, V., Röder, B., Wacker, M.G.
Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans (2019) Journal of controlled release : official journal of the Controlled Release Society, 308, 57–70. http://doi.org/10.1016/j.jconrel.2019.06.029

Janczi, T., Böhm, B.B., Fehrl, Y., DeGiacomo, P., Kinne, R.W., Burkhardt, H.
ADAM15 in Apoptosis Resistance of Synovial Fibroblasts: Converting Fas/CD95 Death Signals Into the Activation of Prosurvival Pathways by Calmodulin Recruitment (2019) Arthritis & rheumatology (Hoboken, N.J.), 71 (1), 63–72. http://doi.org/10.1002/art.40667

Jung, M., Mertens, C., Tomat, E., Brüne, B.
Iron as a Central Player and Promising Target in Cancer Progression (2019) International journal of molecular sciences, 20 (2). http://doi.org/10.3390/ijms20020273

Juretschke, T., Beli, P., Dikic, I.
Quantitative Phosphoproteomics of Selective Autophagy Receptors (2019) Methods in molecular biology (Clifton, N.J.), 1880, 691–701. http://doi.org/10.1007/978-1-4939-8873-0_46

Kambayashi, A., Dressman, J.B.
A novel in vivo predictive dissolution testing coupled with a modeling and simulation for hydrogel matrix monolithic extended release oral dosage forms (2019) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 138, 105044. http://doi.org/10.1016/j.ejps.2019.105044

Kambayashi, A., Dressman, J.B.
Predicting the Changes in Oral Absorption of Weak Base Drugs Under Elevated Gastric pH Using an In Vitro-In Silico-In Vivo Approach: Case Examples-Dipyridamole, Prasugrel, and Nelfinavir (2019) Journal of pharmaceutical sciences, 108 (1), 584–591. http://doi.org/10.1016/j.xphs.2018.11.008

Kambayashi, A., Kiyota, T., Fujiwara, M., Dressman, J.B.
PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion formulations (2019) European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 135, 83–90. http://doi.org/10.1016/j.ejps.2019.05.013

Keminer, O., Teigeler, M., Kohler, M., Wenzel, A., Arning, J., Kaßner, F., Windshügel, B., Eilebrecht, E.
A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes (2019) The Science of the total environment, 134743. http://doi.org/10.1016/j.scitotenv.2019.134743

Keminer, O., Windshügel, B., Essmann, F., Lee, S.M.L., Schiergens, T.S., Schwab, M., Burk, O.
Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3 (2019) Archives of toxicology, 93 (8), 2247–2264. http://doi.org/10.1007/s00204-019-02495-6

Klumpp, L., Nagasekar, K., McCullough, O., Seybert, A., Ashtikar, M., Dressman, J.B.
Stability of Biorelevant Media Under Various Storage Conditions (2019) Dissolution Technologies, 26 (2), 6–18. http://doi.org/10.14227/DT260219P6

Köhm, M., Behrens, F.
Aktuelle Therapie der Psoriasisarthritis (2019) Aktuelle Rheumatologie, 44 (05), 339–344. http://doi.org/10.1055/a-1004-3274

Köhm, M., Behrens, F.
Therapie der Psoriasisarthritis: Gibt es eine Differenzialindikation? (2019) Zeitschrift fur Rheumatologie. http://doi.org/10.1007/s00393-019-00709-x

König, S., Pace, S., Pein, H., Heinekamp, T., Kramer, J.S., Romp, E., Straßburger, M., Troisi, F., Proschak, A., Dworschak, J., Scherlach, K., Rossi, A., Sautebin, L., Haeggström, J.Z., Hertweck, C., Brakhage, A.A., Gerstmeier, J., Proschak, E., Werz, O.
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B4 Formation through Inhibition of Leukotriene A4 Hydrolase (2019) Cell chemical biology, 26 (4), 524-534.e5. http://doi.org/10.1016/j.chembiol.2019.01.001

König, S., Romp, E., Krauth, V., Rühl, M., Dörfer, M., Liening, S., Hofmann, B., Häfner, A.-K., Steinhilber, D., Karas, M., Garscha, U., Hoffmeister, D., Werz, O.
Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159 (2019) Cell chemical biology, 26 (1), 60-70.e4. http://doi.org/10.1016/j.chembiol.2018.10.010

Kramer, J.S., Woltersdorf, S., Duflot, T., Hiesinger, K., Lillich, F.F., Knöll, F., Wittmann, S.K., Klingler, F.-M., Brunst, S., Chaikuad, A., Morisseau, C., Hammock, B.D., Buccellati, C., Sala, A., Rovati, G.E., Leuillier, M., Fraineau, S., Rondeaux, J., Hernández-Olmos, V., Heering, J., Merk, D., Pogoryelov, D., Steinhilber, D., Knapp, S., Bellien, J., Proschak, E.
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Novel Approaches to Persistent Pain Therapy (2019) Trends in pharmacological sciences, 40 (6), 367–377. http://doi.org/10.1016/j.tips.2019.04.003

Smelcerovic, A., Zivkovic, A., Ilic, B.S., Kolarevic, A., Hofmann, B., Steinhilber, D., Stark, H.
4-(4-Chlorophenyl)thiazol-2-amines as pioneers of potential neurodegenerative therapeutics with anti-inflammatory properties based on dual DNase I and 5-LO inhibition (2019) Bioorganic chemistry, 95, 103528. http://doi.org/10.1016/j.bioorg.2019.103528

Smith, D., Buddie, A.G., Goss, R.J.M., Overmann, J., Lepleux, C., Brönstrup, M., Kloareg, B., Meiners, T., Brennecke, P., Ianora, A., Bouget, F.-Y., Gribbon, P., Pina, M.
Discovery pipelines for marine resources: an ocean of opportunity for biotechnology? (2019) World journal of microbiology & biotechnology, 35 (7), 107. http://doi.org/10.1007/s11274-019-2685-y

Snodgrass, R.G., Brüne, B.
Regulation and Functions of 15-Lipoxygenases in Human Macrophages (2019) Frontiers in pharmacology, 10, 719. http://doi.org/10.3389/fphar.2019.00719

Susen, R.M., Bauer, R., Olesch, C., Fuhrmann, D.C., Fink, A.F., Dehne, N., Jain, A., Ebersberger, I., Schmid, T., Brüne, B.
Macrophage HIF-2α regulates tumor-suppressive Spint1 in the tumor microenvironment (2019) Molecular carcinogenesis, 58 (11), 2127–2138. http://doi.org/10.1002/mc.23103

Syed, S.N., Frank, A.-C., Raue, R., Brüne, B.
MicroRNA-A Tumor Trojan Horse for Tumor-Associated Macrophages (2019) Cells, 8 (12). http://doi.org/10.3390/cells8121482

Syed, S.N., Raue, R., Weigert, A., von Knethen, A., Brüne, B.
Macrophage S1PR1 Signaling Alters Angiogenesis and Lymphangiogenesis During Skin Inflammation (2019) Cells, 8 (8). http://doi.org/10.3390/cells8080785

Tarighi, N., Menger, D., Pierre, S., Kornstädt, L., Thomas, D., Ferreirós, N., Nüsing, R.M., Geisslinger, G., Scholich, K.
Thromboxane-Induced α-CGRP Release from Peripheral Neurons Is an Essential Positive Feedback Loop in Capsaicin-Induced Neurogenic Inflammation (2019) The Journal of investigative dermatology, 139 (3), 656–664. http://doi.org/10.1016/j.jid.2018.10.011

Tietgen, M., Kramer, J.S., Brunst, S., Djahanschiri, B., Wohra, S., Higgins, P.G., Weidensdorfer, M., Riedel-Christ, S., Pos, K.M., Gonzaga, A., Steglich, M., Nübel, U., Ebersberger, I., Proschak, E., Göttig, S.
Identification of the novel class D β-lactamase OXA-679 involved in carbapenem resistance in Acinetobacter calcoaceticus (2019) The Journal of antimicrobial chemotherapy, 74 (6), 1494–1502. http://doi.org/10.1093/jac/dkz080

Tiku, V., Dikic, I.
Autophagy without conjugation (2019) Nature structural & molecular biology, 26 (4), 249–250. http://doi.org/10.1038/s41594-019-0207-0

Trümper, V., von Knethen, A., Preuß, A., Ermilov, E., Hackbarth, S., Kuchler, L., Gunne, S., Schäfer, A., Bornhütter, T., Vereb, G., Ujlaky-Nagy, L., Brüne, B., Röder, B., Schindler, M., Parnham, M.J., Knape, T.
Flow cytometry-based FRET identifies binding intensities in PPARγ1 protein-protein interactions in living cells (2019) Theranostics, 9 (19), 5444–5463. http://doi.org/10.7150/thno.29367

V – Z

van Wijk, S.J., Fulda, S., Dikic, I., Heilemann, M.
Visualizing ubiquitination in mammalian cells (2019) EMBO reports, 20 (2). http://doi.org/10.15252/embr.201846520

Vasconez, A.E., Janetzko, P., Oo, J.A., Pflüger-Müller, B., Ratiu, C., Gu, L., Helin, K., Geisslinger, G., Fleming, I., Schröder, K., Fork, C., Brandes, R.P., Leisegang, M.S.
The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase (2019) Acta physiologica (Oxford, England), 225 (1), e13168. http://doi.org/10.1111/apha.13168

Vieider, L., Romp, E., Temml, V., Fischer, J., Kretzer, C., Schoenthaler, M., Taha, A., Hernández-Olmos, V., Sturm, S., Schuster, D., Werz, O., Garscha, U., Matuszczak, B.
Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors (2019) ACS medicinal chemistry letters, 10 (1), 62–66. http://doi.org/10.1021/acsmedchemlett.8b00415

Villa Nova, M., Nothnagel, L., Thurn, M., Travassos, P.B., Herculano, L.S., Bittencourt, P.R.S., Novello, C.R., Bazotte, R.B., Wacker, M.G., Bruschi, M.L.
Development study of pectin/Surelease® solid microparticles for the delivery of L-alanyl-L-glutamine dipeptide (2019) Food Hydrocolloids, 89, 921–932. http://doi.org/10.1016/j.foodhyd.2018.11.038

von Knethen, A., Brüne, B.
Histone Deacetylation Inhibitors as Therapy Concept in Sepsis (2019) International journal of molecular sciences, 20 (2). http://doi.org/10.3390/ijms20020346

von Knethen, A., Brüne, B.
PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology (2019) Signal transduction and targeted therapy, 4, 18. http://doi.org/10.1038/s41392-019-0053-x

von Knethen, A., Schäfer, A., Kuchler, L., Knape, T., Christen, U., Hintermann, E., Fißlthaler, B., Schröder, K., Brandes, R.P., Genz, B., Abshagen, K., Pützer, B.M., Sha, L.K., Weigert, A., Syed, S.N., Schulz, M., Shah, A.M., Ernst, A., Putyrski, M., Finkelmeier, F., Pesic, M., Greten, F., Hogardt, M., Kempf, V.A.J., Gunne, S., Parnham, M.J., Brüne, B.
Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis (2019) Theranostics, 9 (7), 2003–2016. http://doi.org/10.7150/thno.28057

Wallenwein, C.M., Villa Nova, M., Janas, C., Jablonka, L., Gao, G.F., Thurn, M., Albrecht, V., Wiehe, A., Wacker, M.G.
A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes (2019) European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 143, 44–50. http://doi.org/10.1016/j.ejpb.2019.08.010

Walter, C., Oertel, B.G., Felden, L., Nöth, U., Deichmann, R., Lötsch, J.
Delta-9-tetrahydrocannabinol reduces the performance in sensory delayed discrimination tasks. A pharmacological-fMRI study in healthy volunteers (2019) IBRO reports, 7, 117–128. http://doi.org/10.1016/j.ibror.2019.11.004

Wegner, M.-S., Gruber, L., Schömel, N., Trautmann, S., Brachtendorf, S., Fuhrmann, D.C., Schreiber, Y., Olesch, C., Brüne, B., Geisslinger, G., Grösch, S.
GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells (2019) The international journal of biochemistry & cell biology, 112, 95–106. http://doi.org/10.1016/j.biocel.2019.05.002

Wegner, M., Diehl, V., Bittl, V., Bruyn, R. de, Wiechmann, S., Matthess, Y., Hebel, M., Hayes, M.G., Schaubeck, S., Benner, C., Heinz, S., Bremm, A., Dikic, I., Ernst, A., Kaulich, M.
Circular synthesized CRISPR/Cas gRNAs for functional interrogations in the coding and noncoding genome (2019) eLife, 8. http://doi.org/10.7554/eLife.42549

Weigert, A., Olesch, C., Brüne, B.
Sphingosine-1-Phosphate and Macrophage Biology-How the Sphinx Tames the Big Eater (2019) Frontiers in immunology, 10, 1706. http://doi.org/10.3389/fimmu.2019.01706

Weigert, A., von Knethen, A., Thomas, D., Faria, I., Namgaladze, D., Zezina, E., Fuhrmann, D.C., Petcherski, A., Heringdorf, D.M.Z., Radeke, H.H., Brüne, B.
Sphingosine kinase 2 is a negative regulator of inflammatory macrophage activation (2019) Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864 (9), 1235–1246. http://doi.org/10.1016/j.bbalip.2019.05.008

Weyer-Menkhoff, I., Lötsch, J.
TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers (2019) The Clinical journal of pain, 35 (4), 321–327. http://doi.org/10.1097/AJP.0000000000000677

Weyer-Menkhoff, I., Pinter, A., Schlierbach, H., Schänzer, A., Lötsch, J.
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Yuki, K.E., Marei, H., Fiskin, E., Eva, M.M., Gopal, A.A., Schwartzentruber, J.A., Majewski, J., Cellier, M., Mandl, J.N., Vidal, S.M., Malo, D., Dikic, I.
CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection (2019) Nature microbiology, 4 (9), 1516–1531. http://doi.org/10.1038/s41564-019-0484-8

Zschiebsch, K., Fischer, C., Wilken-Schmitz, A., Geisslinger, G., Channon, K., Watschinger, K., Tegeder, I.
Mast cell tetrahydrobiopterin contributes to itch in mice (2019) Journal of cellular and molecular medicine, 23 (2), 985–1000. http://doi.org/10.1111/jcmm.13999

A - C

Al-Hujaily, E.M., Khatlani, T., Alehaideb, Z., Ali, R., Almuzaini, B., Alrfaei, B.M., Iqbal, J., Islam, I., Malik, S., Marwani, B.A., Massadeh, S., Nehdi, A., Alsomaie, B., Debasi, B., Bushnak, I., Noibi, S., Hussain, S., Wajid, W.A., Armand, J.P., Gul, S., Oyarzabal, J., Rais, R., Bountra, C., Alaskar, A., Knawy, B.A., Boudjelal, M.
Therapeutics discovery: from bench to first in-human trials (2018) Biomedical Reports, 8, 275-282. http://doi.org/10.3892/br.2018.1052

Alten, R., Burkhardt, H., Feist, E., Krüger, K., Rech, J., Rubbert-Roth, A., Voll, R.E., Elbez, Y., Rauch, C.
Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: A descriptive analysis of data from interventional trials and the real-world setting (2018) Arthritis Research and Therapy, 20 (1), 1. http://doi.org/10.1186/s13075-017-1488-5

Ashtikar, M., Wacker, M.G.
Nanopharmaceuticals for wound healing – Lost in translation? (2018) Advanced Drug Delivery Reviews, 129, 194-218. http://doi.org/10.1016/j.addr.2018.03.005

Aygören-Pürsün, E., Bygum, A., Grivcheva-Panovska, V., Magerl, M., Graff, J., Steiner, U.C., Fain, O., Huissoon, A., Kinaciyan, T., Farkas, H., Lleonart, R., Longhurst, H.J., Rae, W., Triggiani, M., Aberer, W., Cancian, M., Zanichelli, A., Smith, W.B., Baeza, M.L., Du-Thanh, A., Gompels, M., Gonzalez-Quevedo, T., Greve, J., Guilarte, M., Katelaris, C., Dobo, S., Cornpropst, M., Clemons, D., Fang, L., Collis, P., Sheridan, W., Maurer, M., Cicardi, M.
Oral plasma kallikrein inhibitor for prophylaxis in hereditary angioedema (2018) New England Journal of Medicine, 379 (4), 352-362. http://doi.org/10.1056/NEJMoa1716995

Badalyan, G., Díaz, C., Bücking, M., Lipski, A.
Novel sensor platform for rapid detection and quantification of coliforms on food contact surfaces (2018) Journal of Microbiological Methods, 153, 74-83. http://doi.org/10.1016/j.mimet.2018.09.009

Behrens, F., Koehm, M., Schwaneck, E.C., Schmalzing, M., Gnann, H., Greger, G., Tony, H.-P., Burkhardt, H.
Minimal disease activity is a stable measure of therapeutic response in psoriatic arthritis patients receiving treatment with adalimumab (2018) Rheumatology (Oxford, England), 57 (11), 1938-1946. http://doi.org/10.1093/rheumatology/key203

Behrens, F., Meier, L., Prinz, J.C., Jobst, J., Lippe, R., Löschmann, P.-A., Lorenz, H.-M.
Simultaneous response in several domains in patients with psoriatic disease treated with etanercept as monotherapy or in combination with conventional synthetic disease-modifying antirheumatic drugs (2018) Journal of Rheumatology, 45 (6), 802-810. http://doi.org/10.3899/jrheum.170932

Blum, L., Schiffmann, S., Parnham, M.J.
Immunomodulation by antibiotics (2018) Fighting Antimicrobial Resistance (IAPC Book). http://doi.org/10.5599/obp.15.11

Blum, L., Tafferner, N., Spring, I., Kurz, J., deBruin, N., Geißlinger, G., Parnham, M.J., Schiffmann, S.
Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression (2018) Journal of Molecular Medicine, 96 (10), 1131-1144. http://doi.org/10.1007/s00109-018-1689-7

Böhm, B.B., Fehrl, Y., Janczi, T., Schneider, N., Burkhardt, H.
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Bosma, R., Witt, G., Vaas, L.A.I., Josimovic, I., Gribbon, P., Vischer, H.F., Gul, S., Leurs, R.
The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor (2017) Front Pharmacol, 8:667. http://doi.org/10.3389/fphar.2017.00667

Brachtendorf, S., Wanger, R.A., Birod, K., Thomas, D., Trautmann, S., Wegner, M.-S., Fuhrmann, D.C., Brüne, B., Geißlinger, G., Grösch, S.
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (10), 1214-1227. http://doi.org/10.1016/j.bbalip.2018.07.011

Brand, S., Roy, S., Schröder, P., Rathmer, B., Roos, J., Kapoor, S., Patil, S., Pommerenke, C., Maier, T., Janning, P., Eberth, S., Steinhilber, D., Schade, D., Schneider, G., Kumar, K., Ziegler, S., Waldmann, H.
Combined proteomic and in silico target identification reveal a role for 5-Lipoxygenase in developmental signaling pathways (2018) Cell Chemical Biology, 25 (9), 1095-1106.e23. http://doi.org/10.1016/j.chembiol.2018.05.016

Brandt, S.C., Ellinger, B., van Nguyen, T., Thi, Q.D., van Nguyen, G., Baschien, C., Yurkov, A., Hahnke, R.L., Schäfer, W., Gand, M.
A unique fungal strain collection from Vietnam characterized for high performance degraders of bioecological important biopolymers and lipids (2018) PLoS ONE, 13(8). http://doi.org/10.1371/journal.pone.0202695

Büttner, D., Kramer, J.S., Klingler, F.-M., Wittmann, S.K., Hartmann, M.R., Kurz, C.G., Kohnhäuser, D., Weizel, L., Brüggerhoff, A., Frank, D., Steinhilber, D., Wichelhaus, T.A., Pogoryelov, D., Proschak, E.
Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-β-Lactamases (2018) ACS Infectious Diseases, 4 (3), 360-372. http://doi.org/10.1021/acsinfecdis.7b00129

Burk, O., Kuzikov, M., Kronenberger, T., Jeske, J., Keminer, O., Thasler, W.E., Schwab, M., Wrenger, C., Windshügel, B.
Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles (2018) Archives of Toxicology, 92 (4), 1435-1451. http://doi.org/10.1007/s00204-018-2165-4

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Dauth, S., Köhm, M., Rossmanith, T., Herrmann, E., Lehn, A., Burkhardt, H., Behrens, F.
Stellenwert der Kombination von Biologika mit Methotrexat in der Behandlung der Psoriasisarthritis - Fragen bleiben offen (2018) Zeitschrift fur Rheumatologie.  http://doi.org/10.1007/s00393-018-0533-3

de Bruin, N., Ferreirós, N., Schmidt, M., Hofmann, M., Angioni, C., Geisslinger, G., Parnham, M.J. Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains (2018) Chirality, 30 (5), 632-641. http://doi.org/10.1002/chir.22826

de Witte, W.E.A., Versfelt, J.W., Kuzikov, M., Rolland, S., Georgi, V., Gribbon, P., Gul, S., Huntjens, D., van der Graaf, P.H., Danhof, M., Fernández-Montalván, A., Witt, G., de Lange, E.C.M.
In vitro and in silico analysis of the effects of D2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations (2018) Br J Pharmacol, 175 (21), 4121-4136. http://doi.org/10.1111/bph.14456

Eresch, J., Stumpf, M., Koch, A., Vutukuri, R., Ferreirós, N., Schreiber, Y., Schröder, K., Devraj, K., Popp, R., Hattenbach, L.-O., Pfeilschifter, J., Pfeilschifter, W.Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy(2018) Investigative Ophthalmology and Visual Science, 59 (2), 653-661. http://doi.org/10.1167/iovs.17-22544

Fiehn, C., Holle, J., Iking-Konert, C., Leipe, J., Weseloh, C., Frerix, M., Alten, R., Behrens, F., Baerwald, C., Braun, J., Burkhardt, H., Burmester, G., Detert, J., Gaubitz, M., Gause, A., Gromnica-Ihle, E., Kellner, H., Krause, A., Kuipers, J., Lorenz, H.-M., Müller-Ladner, U., Nothacker, M., Nüsslein, H., Rubbert-Roth, A., Schneider, M., Schulze-Koops, H., Seitz, S., Sitter, H., Specker, C., Tony, H.-P., Wassenberg, S., Wollenhaupt, J., Krüger, K.
S2e guideline: treatment of rheumatoid arthritis with disease-modifying drugs (2018) Zeitschrift fur Rheumatologie, 77, 35-53. http://doi.org/10.1007/s00393-018-0481-y

Genovese, M.C., Combe, B., Kremer, J.M., Tsai, T.-F., Behrens, F., Adams, D.H., Lee, C., Kerr, L., Nash, P.
Safety and efficacy of ixekizumab in patients with PsA and previous inadequate response to TNF inhibitors: week 52 results from SPIRIT-P2 (2018) Rheumatology (Oxford, England), 57 (11), 2001-2011. http://doi.org/10.1093/rheumatology/key182

Gossec, L., McGonagle, D., Korotaeva, T., Lubrano, E., De Miguel, E., Østergaard, M., Behrens, F. Minimal disease activity as a treatment target in psoriatic arthritis: A review of the literature (2018) Journal of Rheumatology, 45 (1), 6-13. http://doi.org/10.3899/jrheum.170449

Häupl, T., Skapenko, A., Hoppe, B., Skriner, K., Burkhardt, H., Poddubnyy, D., Ohrndorf, S., Sewerin, P., Mansmann, U., Stuhlmüller, B., Schulze-Koops, H., Burmester, G.R.
Biomarkers and imaging for diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the BMBF consortium ArthroMark (2018) Zeitschrift fur Rheumatologie, 77, 16-23. http://doi.org/10.1007/s00393-018-0458-x

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R.
Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos (2018) Environmental Science and Pollution Research, 25 (5), 4023-4036. http://doi.org/10.1007/s11356-017-8977-6

Heitel, P., Gellrich, L., Heering, J., Goebel, T., Kahnt, A., Proschak, E., Schubert-Zsilavecz, M., Merk, D.
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro (2018) Scientific Reports, 8 (1), 13554. http://doi.org/10.1038/s41598-018-31833-4

Hering, Y., Berthier, A., Duez, H., Lefebvre, P., Deprez, B., Gribbon, P., Wolf, M., Reinshagen, J., Halley, F., Hannemann, J., Böger, R., Staels, B., Gul, S.
Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα (2018) Journal of Biological Methods, 5 (3), e94. http://doi.org/10.1038/s41598-018-31833-4

Hitzel, J., Lee, E., Zhang, Y., Bibli, S.I., Li, X., Zukunft, S., Pflüger, B., Hu, J., Schürmann, C., Vasconez, A.E., Oo, J.A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C.E., Kroll, J., Jo, H., Landmesser, U., Lusis, A.J., Namgaladze, D., Fleming, I., Leisegang, M.S., Zhu, J., Brandes, R.P. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells (2018) Nature Communications, 9 (1), art. no. 2292. http://doi.org/10.1038/s41467-018-04602-0

Hofmann, M.C.J., Schmidt, M., Arne, O., Geisslinger, G., Parnham, M.J., de Bruin, N.M.W.J.
Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation (2018) Journal of Dermatological Science, 91 (2), 153-163. http://doi.org/10.1016/j.jdermsci.2018.04.013

Jung, F., Nothnagel, L., Gao, F., Thurn, M., Vogel, V., Wacker, M.G. A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling (2018) European Journal of Pharmaceutics and Biopharmaceutics, 127, 462-470. http://doi.org/10.1016/j.ejpb.2018.03.010

Kern, K., Schäfer, S.M.G., Cohnen, J., Pierre, S., Osthues, T., Tarighi, N., Hohmann, S., Ferreiros, N., Brüne, B., Weigert, A., Geißlinger, G., Sisignano, M., Scholich, K.
The G2A receptor controls polarization of macrophage by determining their localization within the inflamed tissue (2018) Frontiers in Immunology, 9, 2261. http://doi.org/10.3389/fimmu.2018.02261

Kirchner, J., Brüne, B., Namgaladze, D. AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages (2018) Scientific Reports, 8 (1), art. no. 7801, http://doi.org/10.1038/s41598-018-26102-3

Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreirós, N., Geißlinger, G., Batista, V.S., Ji, X., Cinatl, J. Jr., Keppler, O.T., Xiong, Y.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1 (2018) Proceedings of the National Academy of Sciences of the United States of America, 115 (43), E10022-E10031. http://doi.org/10.1073/pnas.1805593115

Kraft, C., Boya, P., Codogno, P., Elazar, Z., Eskelinen, E.-L., Farrés, J., Kirkin, V., Jungbluth, H., Martinez, A., Pless, O., Primard, C., Proikas-Cezanne, T., Simonsen, A., Reggiori, F.
Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy (2018) Autophagy. 13,1-5. Online first. http://doi.org/10.1080/15548627.2018.1515532Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E. A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E.
A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13. http://doi.org/10.1016/j.ab.2018.01.023

Kringel, D., Geißlinger, G., Resch, E., Oertel, B.G., Thrun,M.C., Heinemann, S., Lötsch, J.
Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin (2018) Pain, 159 (7), 1366-1381. http://doi.org/10.1097/j.pain.0000000000001222

Kringel, D., Kaunisto, M.A., Lippmann, C., Kalso, E., Lötsch, J.
Development of an AmpliSeqTMPanel for next-generation sequencing of a set of genetic predictors of persisting pain (2018) Frontiers in Pharmacology, 9, 1008. http://doi.org/10.3389/fphar.2018.01008

Kringel, D., Lippmann, C., Parnham, M.J., Kalso, E., Ultsch, A., Lötsch, J.
A machine-learned analysis of human gene polymorphisms modulating persisting pain points to major roles of neuroimmune processes (2018) European Journal of Pain, 22 (10), 1735-1756. http://doi.org/10.1002/ejp.1270

Kronenberger, T., Windshügel, B., Wrenger, C., Honorio, K.M., Maltarollo, V.G. On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity (2018) Journal of Biomolecular Structure and Dynamics, 1-14. Article in Press. http://doi.org/10.1080/07391102.2017.1417161

Kühn, B., Brat, C., Fettel, J., Hellmuth, N., Maucher, I.V., Bulut, U., Hock, K.J., Grimmer, J., Manolikakes, G., Rühl, M., Kühn, A., Zacharowski, K., Matrone, C., Urbschat, A., Roos, J., Steinhilber, D., Maier, T.J.
Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells (2018) Biochemical Pharmacology, 155, 48-60. http://doi.org/10.1016/j.bcp.2018.06.014

Kurz, J., Brunkhorst, R., Foerch, C., Blum, L., Henke, M., Gabriel, L., Ulshöfer, T., Ferreirós, N., Parnham, M.J., Geißlinger, G., Schiffmann, S.
The relevance of ceramides and their synthesizing enzymes for multiple sclerosis (2018) Clinical Science, 132 (17), 1963-1976. http://doi.org/10.1042/CS20180506

Linciano, P., Moraes, C.B., Alcantara, L.M., Franco, C.H., Pascoalino, B., Freitas-Junior, L.H., Macedo, S., Santarem, N., Cordeiro-da-Silva, A., Gul, S., Witt, G., Kuzikov, M., Ellinger, B., Ferrari, S., Luciani, R., Quotadamo, A., Costantino, L., Costi, M.P.
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections (2018) European Journal of Medicinal Chemistry, 25;146, 423-434. http://doi.org/10.1016/j.ejmech.2018.01.043

Lippmann, C., Kringel, D., Ultsch, A., Lötsch, J. Computational functional genomics-based approaches in analgesic drug discovery and repurposing (2018) Pharmacogenomics, 19 (9), 783-797. http://doi.org/10.2217/pgs-2018-0036

Lötsch, J., Geisslinger, G., Heinemann, S., Lerch, F., Oertel, B.G., Ultsch, A.
Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: A machine-learned analysis (2018) Pain, 159 (1), 11-24. http://doi.org/10.1097/j.pain.0000000000001008

Lötsch, J., Kringel, D.
Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications (2018) Clinical Pharmacology and Therapeutics, . Article in Press. http://doi.org/10.1002/cpt.960

Lötsch, J., Lerch, F., Djaldetti, R., Tegder, I., Ultsch, A.
dentification of disease-distinct complex biomarker patterns by means of unsupervised machine-learning using an interactive R toolbox (Umatrix) (2018) BMC Big Data Analytics, 3. http://doi.org/10.1186/s41044-018-0032-1

Lötsch, J., Schiffmann, S., Schmitz, K., Brunkhorst, R., Lerch, F., Ferreiros, N., Wicker, S., Tegeder, I., Geißlinger, G., Ultsch, A.
Machine-learning based lipid mediator serum concentration patterns allow identification of multiple sclerosis patients with high accuracy (2018) Scientific Reports, 8 (1), 14884. http://doi.org/10.1038/s41598-018-33077-8

Lötsch, J., Sipilä, R., Dimova, V., Kalso, E.
Machine-learned selection of psychological questionnaire items relevant to the development of persistent pain after breast cancer surgery (2018) British Journal of Anaesthesia, 121 (5), 1123-1132. http://doi.org/10.1016/j.bja.2018.06.007

Lötsch, J., Sipilä, R., Tasmuth, T., Kringel, D., Estlander, A.-M., Meretoja, T., Kalso, E., Ultsch, A. Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy (2018) Breast Cancer Research and Treatment, 1-13. Article in Press. http://doi.org/10.1007/s10549-018-4841-8

Lötsch, J., Ultsch, A.
Machine learning in pain research (2018) Pain, 159 (4), 623-630. http://doi.org/10.1097/j.pain.0000000000001118

Lötsch, J., Weyer-Menkhoff, I., Tegeder, I. Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings (2018) European Journal of Pain (United Kingdom), 22 (3), 471-484. http://doi.org/10.1002/ejp.1148

Lukin, A., Kramer, J., Hartmann, M., Weizel, L., Hernandez-Olmos, V., Falahati, K., Burghardt, I., Kalinchenkova, N., Bagnyukova, D., Zhurilo, N., Rautio, J., Forsberg, M., Ihalainen, J., Auriola, S., Leppänen, J., Konstantinov, I., Pogoryelov, D., Proschak, E., Dar‘in, D., Krasavin, M.
Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase (2018) Bioorganic Chemistry, 80, 655-667. http://doi.org/10.1016/j.bioorg.2018.07.014

M – O

Maltarollo, V.G., Kronenberger, T., Windshugel, B., Wrenger, C., Trossini, G.H.G., Honorio, K.M.
Advances and Challenges in Drug Design of PPARδ Ligands (2018) Curr Drug Targets. 19 (2),144-154. http://doi.org/10.2174/1389450118666170414113159

Mertens, C., Mora, J., Ören, B., Grein, S., Winslow, S., Scholich, K., Weigert, A., Malmström, P., Forsare, C., Fernö, M., Schmid, T., Brüne, B., Jung, M.
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment (2018) OncoImmunology, 7 (3), e1408751. http://doi.org/10.1080/2162402X.2017.1408751

Moreno-Cinos, C., Sassetti, E., Salado, IG., Witt, G., Benramdane, S., Reinhardt, L., Durante Cruz, C., Joossens, J., Van der Veken, P., Brotz-Oesterhelt, H., Tammela, P., Winterhalter, M., Gribbon, P., Windshügel, B., Augustyns, K.
α-Amino diphenyl phosphonates as novel inhibitors of ­Escherichia coli ClpP protease (2018) Journal of Medicinal Chemistry, American Chemical Society. Online first. http://doi.org/10.1021/acs.jmedchem.8b01466.

Nash, P., Behrens, F., Orbai, A.-M., Rathmann, S.S., Adams, D.H., Benichou, O., Deodhar, A.
Ixekizumab is efficacious when used alone or when added to conventional synthetic disease-modifying antirheumatic drugs (cDMARDs) in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor inhibitors (2018) RMD Open, 4 (2), e000692. http://doi.org/10.1136/rmdopen-2018-000692

Nothnagel, L., Wacker, M.G. How to measure release from nanosized carriers? (2018) European Journal of Pharmaceutical Sciences, 120, 199-211. http://doi.org/10.1016/j.ejps.2018.05.004

P – R

Patas, K., Willing, A., Demiralay, C., Engler, J.B., Lupu, A., Ramien, C., Schäfer, T., Gach, C., Stumm, L., Chan, K., Vignali, M., Arck, P.C., Friese, M.A., Pless, O., Wiedemann, K., Agorastos, A., Gold, S.M. T cell phenotype and T cell receptor repertoire in patients with major depressive disorder (2018) Frontiers in Immunology, 9 (FEB), art. no. 291, http://doi.org/10.3389/fimmu.2018.00291

Piña, M., Colas, P., Cancio, I., Audic, A., Bosser, L., Canario, A., Gribbon, P., Johnston, IA., Kervella, AE., Kooistra, WHCF., Merciecca, M., Magoulas, A., Nardello, I., Smith, D., Pade, N., Robinson, D., Schoen, A., Schultz, F., Kloareg, B.
The European Marine Biological Research Infrastructure Cluster: An Alliance of European Research Infrastructures to Promote the Blue Bioeconomy (2018) Grand Challenges in Marine Biotechnology, Springer, 405-421. http://doi.org/10.1007/978-3-319-69075-9_10

Pleli, T., Mondorf, A., Ferreiros, N., Thomas, D., Dvorak, K., Biondi, R.M., Heringdorf, D.M.Z., Zeuzem, S., Geißlinger, G., Zimmermann, H., Waidmann, O., Piiper, A.
Activation of adenylyl cyclase causes stimulation of adenosine receptors (2018) Cellular Physiology and Biochemistry, 45 (6), 2516-2528. http://doi.org/10.1159/000488270

Proft, F., Schulze-Koops, H., Grunke, M., Schrezenmeier, E., Halleck, F., Henes, J., Unger, L., Schmidt, E., Fiehn, C., Jacobi, A., Iking-Konert, C., Kneitz, C., Schmidt, R.E., Bannert, B., Voll, R.E., Fischer-Betz, R., Kötter, I., Tony, H.P., Holle, J., Aringer, M., Erler, A., Behrens, F., Burmester, G.R., Dörner, T.
Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy: Data from a nationwide German registry (GRAID2) [Sicherheit und Wirksamkeitshinweise zum Off-label-Einsatz von Biologikatherapien nach Versagen konventioneller Therapien bei Patienten mit entzündlich rheumatischen Erkrankungen: Ergebnisse eines nationalen Registers (GRAID2)] (2018) Zeitschrift fur Rheumatologie, 77 (1), 28-39. http://doi.org/10.1007/s00393-017-0330-4

Ringleb, J., Strack, E., Angioni, C., Geißlinger, G., Steinhilber, D., Weigert, A., Brüne, B.
Apoptotic Cancer Cells Suppress 5-Lipoxygenase in Tumor-Associated Macrophages (2018) Journal of Immunology, 200 (2), 857-868. http://doi.org/10.4049/jimmunol.1700609

Roos, J., Peters, M., Maucher, I.V., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Sommer, B., Urbschat, A., Piesche, M., Vogel, A., Proschak, E., Blöcher, R., Buscató, E., Häfner, A.-K., Matrone, C., Werz, O., Heidler, J., Wittig, I., Angioni, C., Geisslinger, G., Parnham, M.J., Zacharowski, K., Steinhilber, D., Maier, T.J. Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy (2018) Antioxidants and Redox Signaling, 28 (14), 1265-1285. http://doi.org/10.1089/ars.2017.7155

S – U

Sala, A., Proschak, E., Steinhilber, D., Rovati, G.E.
Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade (2018) Biochemical Pharmacology, 158, 161-173. http://doi.org/10.1016/j.bcp.2018.10.007

Schierle, S., Flauaus, C., Heitel, P., Willems, S., Schmidt, J., Kaiser, A., Weizel, L., Goebel, T., Kahnt, A.S., Geißlinger, G., Steinhilber, D., Wurglics, M., Rovati, G.E., Schmidtko, A., Proschak, E., Merk, D.
Boosting anti-inflammatory potency of zafirlukast by designed polypharmacology (2018) Journal of Medicinal Chemistry, 61 (13), 5758-5764. http://doi.org/10.1021/acs.jmedchem.8b00458

Sehnert, B., Burkhardt, H., Finzel, S., Dübel, S., Voll, R.E. The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways (2018) Clinical Immunology, 186,  14-20. http://doi.org/10.1016/j.clim.2017.08.018

Sekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A.F., Brüne, B., Rodriguez-Barbosa, J.I., Weigert, A. Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma (2018) International Journal of Molecular Sciences, 19 (3), art. no. 752, http://doi.org/10.3390/ijms19030752

Shiratori, H., Feinweber, C., Luckhardt, S., Wallner, N., Geisslinger, G., Weigert, A., Parnham, M.J. An in vitro test system for compounds that modulate human inflammatory macrophage polarization (2018) European Journal of Pharmacology, 833, 328-338. http://doi.org/10.1016/j.ejphar.2018.06.017

Snodgrass, R.G., Zezina, E., Namgaladze, D., Gupta, S., Angioni, C., Geißlinger, G., Lütjohann, D., Brüne, B.
A novel function for 15-Lipoxygenases in cholesterol homeostasis and CCL17 production in human macrophages. (2018) Front Immunol 1906 (9), 1-16. http://doi.org/10.3389/fimu.2018.01906

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M.
Comparative analysis of the transcriptome responses of zebrafish embryos after exposure to low concentrations of cadmium, cobalt and copper (2018) Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 25, 99-108. http://doi.org/10.1016/j.cbd.2017.12.001

Spry, C., Sewell, A.L., Hering, Y., Villa, M.V.J., Weber, J., Hobson, S.J., Harnor, S.J., Gul, S., Marquez, R., Saliba, K.J. Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation http://doi.org/10.1016/j.ejmech.2017.08.050

Stoessel, D., Stellmann, J.-P., Willing, A., Behrens, B., Rosenkranz, S.C., Hodecker, S.C., Stürner, K.H., Reinhardt, S., Fleischer, S., Deuschle, C., Maetzler, W., Berg, D., Heesen, C., Walther, D., Schauer, N., Friese, M.A., Pless, O.
Metabolomic profiles for primary progressive multiple sclerosis stratification and disease course monitoring (2018) Frontiers in Human Neuroscience, 12, 226. http://doi.org/10.3389/fnhum.2018.00226

Stürner, K.H., Stellmann, J.-P., Dörr, J., Paul, F., Friede, T., Schammler, S., Reinhardt, S., Gellissen, S., Weissflog, G., Faizy, T.D., Werz, O., Fleischer, S., Vaas, L.A.I., Herrmann, F., Pless, O., Martin, R., Heesen, C.
A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial) (2018) Journal of Neurology, Neurosurgery and Psychiatry, 89 (4), 330-338. http://doi.org/10.1136/jnnp-2017-317101

Tandon, R., Brändl, B., Baryshnikova, N., Landshammer, A., Steenpaß, L., Keminer, O., Pless, O., Müller, F.-J.
Generation of two human isogenic iPSC lines from fetal dermal fibroblasts (2018) Stem Cell Research, 33, 120-124. http://doi.org/10.1016/j.scr.2018.10.004

Thalman, C., Horta, G., Qiao, L., Endle, H., Tegeder, I., Cheng, H., Laube, G., Sigrudsson, T., Hauser, M.J., Tenzer, S., Distler, U., Aoki, J., Morris, A.J., Geißlinger, G., Röper, J., Kirischuk, S., Luhmann, H.J., Radyushkin, K., Nitsch, R., Vogt, J.
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders (2018) Molecular Psychiatry, 23 (8), 1699-1710. http://doi.org/10.1038/s41380-018-0053-1

Toewe, A., Balas, L., Durand, T., Geisslinger, G., Ferreirós, N. Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry (2018) Analytica Chimica Acta, . Article in Press. http://doi.org/10.1016/j.aca.2018.05.020

Treutlein, E.-M., Kern, K., Weigert, A., Tarighi, N., Schuh, C.-D., Nüsing, R.M., Schreiber, Y., Ferreirós, N., Brüne, B., Geißlinger, G., Pierre, S., Scholich, K.
The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2–mediated neuropathic pain induced by mechanical nerve damage (2018) Journal of Biological Chemistry, 293 (25), 9685-9695. http://doi.org/10.1074/jbc.RA118.002492

Trillhaase, A., Haferkamp, U., Rangnau, A., Märtens, M., Schmidt, B., Trilck, M., Seibler, P., Aherrahrou, R., Erdmann, J., Aherrahrou, Z.
Differentiation of human iPSCs into VSMCs and generation of VSMC-derived calcifying vascular cells (2018) Stem Cell Research, 31, 62-70. http://doi.org/10.1016/j.scr.2018.07.008

Tunaru, S., Bonnavion, R., Brandenburger, I., Preussner, J., Thomas, D., Scholich, K., Offermanns, S.
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1 (2018) Nature Communications, 9 (1), 177. http://doi.org/10.1038/s41467-017-02539-4

Uliassi, E., Piazzi, L., Belluti, F., Mazzanti, A., Kaiser, M., Brun, R., Moraes, C.B., Freitas-Junior, L.H., Gul, S., Kuzikov, M., Ellinger, B., Borsari, C., Costi, M.P., Bolognesi, M.L.
Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections (2018) ChemMedChem, 13 (7), 678-683. http://doi.org/10.1002/cmdc.201700786

V – Z

Van Vollenhoven, R.F., Keystone, E.C., Strand, V., Pacheco-Tena, C., Vencovský, J., Behrens, F., Racewicz, A., Zipp, D., Rharbaoui, F., Wolter, R., Knierim, L., Schmeidl, R., Zhou, X., Aigner, S., Dälken, B., Wartenberg-Demand, A.
Efficacy and safety of tregalizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase IIb, randomised, placebo-controlled trial (2018) Annals of the Rheumatic Diseases, 77 (4), 495-499. http://doi.org/10.1136/annrheumdis-2017-212478

Vögtle, F.-N., Brändl, B., Larson, A., Pendziwiat, M., Friederich, M.W., White, S.M., Basinger, A., Kücükköse, C., Muhle, H., Jähn, J.A., Keminer, O., Helbig, K.L., Delto, C.F., Myketin, L., Mossmann, D., Burger, N., Miyake, N., Burnett, A., van Baalen, A., Lovell, M.A., Matsumoto, N., Walsh, M., Yu, H.-C., Shinde, D.N., Stephani, U., Van Hove, J.L.K., Müller, F.-J., Helbig, I.
Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood (2018) American Journal of Human Genetics, 102 (4), 557-573. http://doi.org/10.1016/j.ajhg.2018.02.014

Vollert, J., Magerl, W., Baron, R., Binder, A., Enax-Krumova, E.K., Geißlinger, G., Gierthmuhlen, J., Henrich, F., Hullemann, P., Klein, T., Lotsch, J., Maier, C., Oertel, B., Schuh-Hofer, S., Tolle, T.R., Treede, R.-D.
Pathophysiological mechanisms of neuropathic pain: Comparison of sensory phenotypes in patients and human surrogate pain models (2018) Pain, 159 (6), 1090-1102. http://doi.org/10.1097/j.pain.0000000000001190

Wacker, M.G., Janas, C., Ferreira, F.S., Vieira, F.P.
Manufacturing and Safety Guidelines for Manufactured Functionalized Nanomaterials in Pharmaceutics (2018) Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation, 623-651. http://doi.org/10.1016/B978-0-323-50878-0.00021-5

Wegner, M.-S., Gruber, L., Mattjus, P., Geißlinger, G., Grösch, S.
The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1) (2018) BMC Cancer, 18 (1), 153. http://doi.org/10.1186/s12885-018-4084-4

Wegner, M.-S., Schömel, N., Gruber, L., Örtel, S.B., Kjellberg, M.A., Mattjus, P., Kurz, J., Trautmann, S., Peng, B., Wegner, M., Kaulich, M., Ahrends, R., Geisslinger, G., Grösch, S.
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells (2018) Cellular and Molecular Life Sciences, 75 (18), 3393-3410. http://doi.org/10.1007/s00018-018-2799-7

Weigert, A., von Knethen, A., Fuhrmann, D., Dehne, N., Brüne, B. Redox-signals and macrophage biology (for the upcoming issue of molecular aspects of medicine on signaling by reactive oxygen species) (2018) Molecular Aspects of Medicine, http://doi.org/10.1016/j.mam.2018.01.003

Weyer-Menkhoff, I., Lötsch, J.
Human pharmacological approaches to TRP-ion-channel-based analgesic drug development (2018) Drug Discovery Today, 23 (12), 2003-2012, http://doi.org/10.1016/j.drudis.2018.06.020

Weyer-Menkhoff, I., Thrun, M.C., Lötsch, J. Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects (2018) European Journal of Pain (United Kingdom), 22 (5), 862-874. http://doi.org/10.1002/ejp.1173

Winau, L., Hinojar Baydes, R., Braner, A., Drott, U., Burkhardt, H., Sangle, S., D‘Cruz, D.P., Carr-White, G., Marber, M., Schnoes, K., Arendt, C., Klingel, K., Vogl, T.J., Zeiher, A.M., Nagel, E., Puntmann, V.O.
High-sensitive troponin is associated with subclinical imaging biosignature of inflammatory cardiovascular involvement in systemic lupus erythematosus (2018) Annals of the Rheumatic Diseases, 77 (11), 1590-1598. http://doi.org/10.1136/annrheumdis-2018-213661

Windshügel, B.
Structural Insights into Ligand-Binding Pocket Formation in Nurr1 by Molecular Dynamics Simulations (2018) Journal of Biomolecular Structure and Dynamics. http://doi.org/10.1080/07391102.2018.1559099

Zezina, E., Snodgrass, R.G., Schreiber, Y., Zukunft, S., Schürmann, C., Heringdorf, D.M.Z., Geißlinger, G., Fleming, I., Brandes, R.P., Brüne, B., Namgaladze, D.
Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (4), 433-446. http://doi.org/10.1016/j.bbalip.2018.01.009

Zhong, J., Scholz, T., Yau, A.C.Y., Guerard, S., Hüffmeier, U., Burkhardt, H., Holmdahl, R.
Mannan-induced Nos2 in macrophages enhances IL-17-driven psoriatic arthritis by innate lymphocytes (2018) Science Advances, 4 (5), eaas9864. http://doi.org/10.1126/sciadv.aas9864

Zimmer, B., Angioni, C., Osthues, T., Toewe, A., Thomas, D., Pierre, S.C., Geisslinger, G., Scholich, K., Sisignano, M. The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (7), 669-678. http://doi.org/10.1016/j.bbalip.2018.03.012

Behrens, F., Thaci, D., Wollenhaupt, J., Kruger, K., 2017 Psoriatic arthritis : Overview of drug therapy options and administration characteristics. Hautarzt No. 68(2): 153-169. http://doi.org/10.1007/s00105-016-3925-9

Bender, C., Christen, S., Scholich, K., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U., 2017 Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes. Diabetes (2017) No. 66(1): 113-126. http://doi.org/10.2337/db16-0547

Borsari, C., Santarem, N., Torrado, J., Olías, A.I., Corral, M.J., Baptista, C., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Witt, G., Gribbon, P., Reinshagen, J., Linciano, P., Tait, A., Costantino, L., Freitas-Junior, L.H., Moraes, C.B., Bruno dos Santos, P., Alcântara, L.M., Franco, C.H., Bertolacini, C.D., Fontana, V., Tejera Nevado, P., Clos, J., Alunda, J.M., Cordeiro-da-Silva, A., Ferrari, S., Costi, M.P., 2017. Methoxylated 2’-hydroxychalcones as antiparasitic hit compounds. European Journal of Medicinal Chemistry 126, 1129–1135. http://doi.org/10.1016/j.ejmech.2016.12.017

Dehne, N., Mora, J., Namgaladze, D., Weigert, A., Brüne, B., 2017. Cancer cell and macrophage cross-talk in the tumor microenvironment. Current Opinion in Pharmacology 35, 12–19. http://doi.org/10.1016/j.coph.2017.04.007

Di Pisa, F., Landi, G., Dello Iacono, L., Pozzi, C., Borsari, C., Ferrari, S., Santucci, M., Santarem, N., Cordeiro-Da-Silva, A., Moraes, C.B., Alcantara, L.M., Fontana, V., Freitas-Junior, L.H., Gul, S., Kuzikov, M., Behrens, B., Pöhner, I., Wade, R.C., Costi, M.P., Mangani, S., 2017. Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity. Molecules 22. http://doi.org/10.3390/molecules22030426

Dimova, V., Oertel, B.G., Lötsch, J., 2017. Using a standardized clinical quantitative sensory testing battery to judge the clinical relevance of sensory differences between adjacent body areas. Clinical Journal of Pain 33, 37–43. http://doi.org/10.1097/AJP.0000000000000372

Florian, P., Wonerow, P., Harder, S., Kuczka, K., Dubar, M., Graff, J., 2017. Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber. Eur J Clin Pharmacol 73, 949–956. http://doi.org/10.1007/s00228-017-2264-9

Fuhrmann, D.C., Brüne, B., 2017. Mitochondrial composition and function under the control of hypoxia. Redox Biology 12, 208–215. http://doi.org/10.1016/j.redox.2017.02.012

Grösch, S., Niederberger, E., Geisslinger, G., 2017. Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain. Expert Opinion on Investigational Drugs 26, 51–61. http://doi.org/10.1080/13543784.2017.1260544

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R., 2017. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos. Environ Sci Pollut Res 1–14. http://doi.org/10.1007/s11356-017-8977-6

Hohmann, S.W., Angioni, C., Tunaru, S., Lee, S., Woolf, C.J., Offermanns, S., Geisslinger, G., Scholich, K., Sisignano, M., 2017. The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Scientific Reports 7. http://doi.org/10.1038/s41598-017-00591-0

Janas, C., Mast, M.-P., Kirsamer, L., Angioni, C., Gao, F., Mäntele, W., Dressman, J., Wacker, M.G., 2017. The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers. European Journal of Pharmaceutics and Biopharmaceutics 115, 73–83. http://doi.org/10.1016/j.ejpb.2017.02.006

Jeske, J., Windshügel, B., Thasler, W.E., Schwab, M., Burk, O., 2017. Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor. Archives of Toxicology 91, 2375–2390. http://doi.org/10.1007/s00204-017-1948-3

Jung, M., Mertens, C., Bauer, R., Rehwald, C., Brüne, B., 2017a. Lipocalin-2 and iron trafficking in the tumor microenvironment. Pharmacological Research 120, 146–156. http://doi.org/10.1016/j.phrs.2017.03.018

Jung, M., Weigert, A., Mertens, C., Rehwald, C., Brüne, B., 2017b. Iron handling in tumor-associated macrophages-Is there a new role for lipocalin-2? Frontiers in Immunology 8. http://doi.org/10.3389/fimmu.2017.01171

Koch, A., Grammatikos, G., Trautmann, S., Schreiber, Y., Thomas, D., Bruns, F., Pfeilschifter, J., Badenhoop, K., Penna-Martinez, M., 2017. Vitamin D supplementation enhances C18(Dihydro)ceramide levels in type 2 diabetes patients. International Journal of Molecular Sciences 18. http://doi.org/10.3390/ijms18071532

Kringel, D., Sisignano, M., Zinn, S., Lötsch, J., 2017. Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeqTM panel. PLoS ONE 12. http://doi.org/10.1371/journal.pone.0180116

Niederberger, E., Resch, E., Parnham, M.J., Geisslinger, G., 2017. Drugging the pain epigenome. Nature Reviews Neurology 13, 434–447. http://doi.org/10.1038/nrneurol.2017.68

Oertel, S., Scholich, K., Weigert, A., Thomas, D., Schmetzer, J., Trautmann, S., Wegner, M.-S., Radeke, H.H., Filmann, N., Brüne, B., Geisslinger, G., Tegeder, I., Grösch, S., 2017. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell. Mol. Life Sci. 74, 3039–3055. http://doi.org/10.1007/s00018-017-2518-9

Parnham, M.J., 2017. Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications. Inflammation Research 66. http://doi.org/10.1007/s00011-016-0988-0

Pierre, S., Linke, B., Suo, J., Tarighi, N., Del Turco, D., Thomas, D., Ferreiros, N., Stegner, D., Frölich, S., Sisignano, M., Meyer Dos Santos, S., deBruin, N., Nüsing, R.M., Deller, T., Nieswandt, B., Geisslinger, G., Scholich, K., 2017. GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. Journal of Investigative Dermatology 137, 686–695. http://doi.org/10.1016/j.jid.2016.09.036

Rahlff, J., Peters, J., Moyano, M., Pless, O., Claussen, C., Peck, M.A., 2017. Short-term molecular and physiological responses to heat stress in neritic copepods Acartia tonsa and Eurytemora affinis. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology 203, 348–358. http://doi.org/10.1016/j.cbpa.2016.11.001

Schneider, C., Oellerich, T., Baldauf, H.-M., Schwarz, S.-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W.E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M.-L., Yakunin, A.F., Geisslinger, G., Ströbel, P., Ferreirós, N., Serve, H., Keppler, O.T., Cinatl, J., 2017. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nature Medicine 23, 250–255. http://doi.org/10.1038/nm.4255

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M., 2017. Concentration dependent transcriptome responses of zebrafish embryos after exposure to cadmium, cobalt and copper. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics 24, 29–40. http://doi.org/10.1016/j.cbd.2017.07.004

Stolz, A., Putyrski, M., Kutle, I., Huber, J., Wang, C., Major, V., Sidhu, S.S., Youle, R.J., Rogov, V.V., Dötsch, V., Ernst, A., Dikic, I., 2017. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO Journal 36, 549–564. http://doi.org/10.15252/embj.201695063

Ueck, C., Volksdorf, T., Houdek, P., Vidal-Y-Sy, S., Sehner, S., Ellinger, B., Lobmann, R., Larena-Avellaneda, A., Reinshagen, K., Ridderbusch, I., Kohrmeyer, K., Moll, I., Daniels, R., Werner, P., Merfort, I., Brandner, J.M., 2017. Comparison of in-vitro and ex-vivo wound healing assays for the investigation of diabetic wound healing and demonstration of a beneficial effect of a triterpene extract. PLoS ONE 12. http://doi.org/10.1371/journal.pone.0169028

von Delius, M., Le, C.M., Ellinger, B., Kuzikov, M., Gul, S., Dong, V.M., 2017. Synthesis and Biological Activity of Octaketides from the Cytosporone Family. Israel Journal of Chemistry 57, 975–981. http://doi.org/10.1002/ijch.201700023

Wobst, I., Ebert, L., Birod, K., Wegner, M.-S., Hoffmann, M., Thomas, D., Angioni, C., Parnham, M.J., Steinhilber, D., Tegeder, I., Geisslinger, G., Grösch, S., 2017. R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4. International Journal of Molecular Sciences 18. http://doi.org/10.3390/ijms18010068

Zinn, S., Sisignano, M., Kern, K., Pierre, S., Tunaru, S., Jordan, H., Suo, J., Treutlein, E.-M., Angioni, C., Ferreiros, N., Leffler, A., Debruin, N., Offermanns, S., Geisslinger, G., Scholich, K., 2017. The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. Journal of Biological Chemistry 292, 6123–6134. http://doi.org/10.1074/jbc.M116.769125

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Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, Bernal- Delgado E. et al.: Making sense of big data in health research: Towards an EU action plan. Genome Medicine (2016) No.8(1): 71 (http://doi.org/10.1186/s13073-016-0323-y)

Aygören-Pürsün, E., Magerl, M., Graff, J., Martinez-Saguer, I., Kreuz, W., Longhurst, H., Nasr, I., Bas, M., Straßen, U., Fang, L., Cornpropst, M., Dobo, S., Collis, P., Sheridan, W.P., Maurer, M.: Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. The Journal of Allergy Clinical Immunology (2016) pii: S0091-6749(16)30270-6 (http://doi.org/10.1016/j.jaci.2016.03.043)

Barthelmes, J., Tafferner, N., Kurz, J., de Bruin, N., Parnham, M.J., Geisslinger, G., Schiffmann, S.: Induction of experimental autoimmune encephalomyelitis in mice and evaluation of the disease-dependent distribution of immune cells in various tissues. Journal of visualized experiments: JoVE. Online resource 2016 (2016) No. 111 (http://doi.org/10.3791/53933)

Behrens, F., Koehm, M., Thaci, D., Gnann, H., Greger, G., Wittig, B.M., Burkhardt, H.: Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis. Rheumatology 55 (2016) No. 10: 1791- 1795 (http://doi.org/10.1093/rheumatology/kew229)

Behrens, F., Koehm, M., Arndt, U., Wittig, B.M., Greger, G., Thaci, D., Scharbatke, E., Tony, H.-P., Burkhardt, H.: Does concomitant methotrexate with Progadalimumab influence treatment outcomes in patients with psoriatic arthritis? Data from a large observational study. The Journal of Rheumatology 43 (2016) No. 3: 632-639 (http://doi.org/10.3899/jrheum.141596)

Behrens, F., Thaci, D., Wollenhaupt, J., Krüger, K.: Psoriasisarthritis: Übersicht medikamentöser Therapieoptionen und Anwendungsbesonderheiten. Zeitschrift für Rheumatologie 75 (2016) No. 5, 471-488 (http://doi.org/10.1007/s00393-016-0110-6)

Beyer, S., Xie, L., Schmidt, M., de Bruin, N., Ashtikar, M., Rüschenbaum, S., Lange, C.M., Vogel, V.; Mäntele, W., Parnham, M.J., Wacker, M.G.: Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques. Journal of controlled release 235 (2016), 352-364 (http://doi.org/10.1016/j.jconrel.2016.06.013)

Blöcher, R., Lamers, C., Wittmann, S.K., Merk, D., Hartmann, M., Weizel, L., Diehl, O., Brüggerhoff, A., Boss, M., Kaiser, A., Schader, T., Gobel, T., Grundmann, M., Angioni, C., Heering, J., Geisslinger, G., Wurglics, M., Kostenis, E., Brüne, B., Steinhilber, D., Schubert-Zsilavecz, M., Kahnt, A.S., Proschak, E.: N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators. Journal of medicinal chemistry 59 (2016) No. 1: 61-81 (http://doi.org/10.1021/acs.jmedchem.5b01239)

Bodewein, L., Schmelter, F., Di Fiore, S., Hollert, H., Fischer, R., Fenske, M.: Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines. Toxicology and Applied Pharmacology 305 (2016) 83-92 (http://doi.org/10.1016/j.taap.2016.06.008)

Borsari, C., Luciani, R., Pozzi, C., Poehner, I., Henrich, S., Trande, M., Cordeiro-da- Silva, A., Santarem, N., Baptista, C., Tait, A., Di Pisa, F., Dello Iacono, L., Landi, G., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Gribbon, P., Kohler, M., Keminer, O., Behrens, B., Costantino, L., Tejera Nevado, P., Bifeld, E., Eick, J., Clos, J., Torrado, J., Jiménez- Antón, M.D., Corral, M.J., Alunda, J.M., Pellati, F., Wade, R.C., Ferrari, S., Mangani, S., Costi, M.P.: Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs. Journal of Medicinal Chemistry (2016) No. 59(16): 7598-7616 (http://doi.org/10.1021/acs.jmedchem.6b00698)

Boß, M., Newbatt, Y., Gupta, S., Collins, I., Brüne, B., Namgaladze, D.: AMPK-independent inhibition of human macrophage ER stress response by AICAR. Scientific Reports 6 (2016), Art. 32111, 10 (http://doi.org/10.1038/srep32111)

Brändl, B., Schuldt, B.M., Böhnke, L., Keminer, O., Vaas, L.A.I., Fischer, R., Müller, F.J., Pless, O.: Utilizing regulatory networks for pluripotency assessment in stem cells. Current Stem Cell Reports (2016), No. 2(3): 228-235. Review. (http://dx.doi.org/10.1007%2Fs40778-016-0054-4)

Brenke, J.K., Salmina, E.S., Ringelstetter, L., Dornauer, S., Kuzikov, M., Rothenaigner, I., Schorpp, K., Giehler, F., Gopalakrishnan, J., Kieser, A., Gul, S., Tetko, I.V., Hadian, K.: Identification of small-molecule frequent hitters of glutathione s-transferase- glutathione interaction. Journal of Biomolecular Screening 21 (2016) No.6: 596-607 (http://doi.org/10.1177/1087057116639992)

Brenneis, M., Aghajaanpour, R., Knape, T., Sha, L.K., Neb, H., Meybohm, P., Zacharowski, K., Hauser, I.A., Buttner, S., Parnham, M.J., Brune, B., Von Knethen, A.: Pparg Expression in T Cells as a Prognostic Marker of Sepsis. Shock 45 (2016), No. 6: 591-597 (http://doi.org/10.1097/SHK.0000000000000568)

Briken, S., Rosenkranz, S.C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Hellweg, R., Pless, O., Schulz, K.H., Gold, S.M.: Effects of exercise on irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of Neuroimmunology (2016) No. 299: 53-58 (http://doi.org/10.1016/j.jneuroim.2016.08.007)

Brüne, B., Courtial, N., Dehne, N., Syed, S.N., Weigert, A.: Macrophage NOS2 in tumor leukocytes. Antioxidants & Redox Signaling. [Epub ahead of print] (http://doi.org/10.1089/ars.2016.6811)

Bruin, N.M.W.J. de, Schmitz, K., Schiffmann, S., Tafferner, N., Schmidt, M., Jordan, H., Häußler, A., Tegeder, I., Geisslinger, G., Parnham, M.J.: Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behavioural Brain Research 300 (2016) 160-174 (http://doi.org/10.1016/j.bbr.2015.12.006)

Bruin de, N.M.W.J., van Loevezijn, A., Wicke, K.M., de Haan, M., Venhorst, J., Lange, J.H.M., de Groote, L., van der Neut, M.A.W., Prickaerts, J., Andriambeloson, E., Foley, A.G., van Drimmelen, M., van der Wetering, M., Kruse, C.G.: The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment. Neurobiology of Learning and Memory (2016) No. 133: 100–117 (http://doi.org/10.1016/j.nlm.2016.06.020) )

Budu-Aggrey, A., Bowes, J. Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., Fitzgerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A.; Barton, A.: Replication of a distinct psoriatic arthritis risk variant at the IL23R locus. Annals of the rheumatic diseases 75 (2016) No. 7: 1417-1418 (http://doi.org/10.1136/annrheumdis-2016-209290)

Budu-Aggrey, A., Bowes, J. Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., FitzGerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A., Barton, A.: Validation of a distinct psoriatic arthritis risk variant at IL23R. Rheumatology 55 (2016), Supplement 1, Abstract 219, i150-i151

Burkhardt, H., Weisenseel, P., Radtke, M.A., Krüger, K.: Hautmalignome und immunmodulierende Antirheumatikatherapie. Zeitschrift für Rheumatologie 75 (2016), No. 1: 32-40 (http://doi.org/10.1007/s00393-015-0037-3)

Capelo, R., Lehmann, C., Ahmad, K., Snodgrass, R., Diehl, O., Ringleb, J., Flamand, N., Weigert, A., Stark, H., Steinhilber, D., Kahnt, A.S.: Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochemical pharmacology 103 (2016) 74-84 (http://doi.org/10.1016/j.bcp.2016.01.007)

Combe, B., Behrens, F., McHugh, N., Brock, F., Kerkmann, U., Kola, B., Gallo, G.: Comparison of etanercept monotherapy and combination therapy with methotrexate in psoriatic arthritis: Results from 2 clinical trials. The Journal of Rheumatology 43 (2016) No. 6: 1063-1067 (http://doi.org/10.3899/jrheum.151290)

 

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de Araujo, L.S., Vaas, L.A., Ribeiro-Alves, M., Geffers, R., Mello, F.C., de Almeida, A.S., Moreira, A.D., Kritski, A.L., Lapa, E Silva JR, Moraes, M.O., Pessler, F., Saad, M.H.: Transcriptomic biomarkers for tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA expression in peripheral blood. Frontiers in Microbiology (2016) No. 7: 1586 (http://doi.org/10.3389/fmicb.2016.01586)

Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Finl, A.F., Roberts, E., Brüne, B., Weigert, A.: S1PR4 signaling attenuates ILT7 internalization to limit IFN-a production by human plasmacytoid dendritic cells. The Journal of Immunology (2016) No. 196 (4): 1579-1590 (http://doi.org/10.4049/jimmunol.1403168)

Drebes, J., Künz, M., Windshügel, B., Kikhney, A.G., Müller, I.B., Eberle, R.J., Oberthür, D., Cang, H., Svergun, D.I., Perbandt, M., Betzel, C., Wrenger, C.: Structure of ThiM from vitamin B1 biosynthetic pathway of Staphylococcus aureus – insights into a novel pro-drug approach addressing MRSA infections. Scientific Reports (2016) No. 6: 22871 (http://doi.org/10.1038/srep22871)

Ellinger, B., Gribbon P.: Risk mitigation in academic drug discovery. Expert Opinion on Drug Discovery (2016) No. 133(4): 333-336 (http://doi.org/10.1517/17460441.2016.1152257)

Fenske, M., Gul, S.: Zebrafish early-life stages as neurological screening and detection tools. Drug Target Review, Volume 3, Autumn 2016, 41-43 (URL: https://www.drugtargetreview.com/article/14205/hit-to-lead-in-depth-focus-2016/)

Frenz, T., Grabski, E., Buschjäger, D., Vaas, L.A., Burgdorf, N., Schmidt, R.E., Witte, T., Kalinke, U.: CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. The Journal of Allergy Clinical Immunology (2016) No. 138(2): 586-589.e10 (http://doi.org/10.1016/j.jaci.2016.04.013)

 

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Graff, J., Scheuermann, E.H., Brandhorst, G., Oellerich, M., Gossmann, J.: Pharmacokinetic analysis of mycophenolate mofetil and enteric-coated mycophenolate sodium in calcineurin inhibitor-free renal transplant recipients. Ther Drug Monit. (2016) No. 38(3): 388-392 (http://doi.org/10.1097/FTD.0000000000000281)

Grimm, M., Tischner, D., Troidl, K., Albarran Juarez, J., Sivaraj, K. K., Ferreiros Bouzas, N., Geisslinger, G., Binder, C. J., Wettschureck, N.: S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population. Arteriosclerosis, Thrombosis, and Vascular Biology 36 (2016) No. 1: 37-48 (http://doi.org/10.1161/ATVBAHA.115.306066)

Hanke, T., Merk, D., Steinhilber, D., Geisslinger, G., Schubert-Zsilavecz, M.: Small molecules with anti-inflammatory properties in clinical development. Pharmacology & therapeutics 157 (2016) 163-87 (http://doi.org/10.1016/j.pharmthera.2015.11.011)

Hauser, A.S., Windshügel, B.: LEADS-PEP: A benchmark data set for assessment of peptide docking performance. Journal of Chemical Information and Modeling 2016 Jan 25; No. 56(1): 188- 200 (http://doi.org/10.1021/acs.jcim.5b00234)

Henke, N., Ferreiros, N., Geisslinger, G., Ding, M. G., Essler, S., Fuhrmann, D. C., Geis, T., Namgaladze, D., Dehne, N., Brune, B.: Loss of HIF-1alpha in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model. Oncotarget 7 (2016) No. 18: 25915-29 (http://doi.org/10.18632/oncotarget.8297)

Hunzelmann, N., Riemekasten, G., Becker, M.O., Moinzadeh, P., Kreuter, A., Melchers, I., Mueller-Ladner, U., Meier, F., Worm, M., Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Günther, C., Sárdy, M., Burkhardt, H., Koehm, M., Kuhr, K., Krieg, T., Sunderkötter, C.: The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase- 1 antibodies. The British Journal of Dermatology 174 (2016) No. 6: 1384-1387 (http://doi.org/10.1111/bjd.14367)

Josipovic, I., Fork, C., Preussner, J., Prior, K. K., Iloska, D., Vasconez, A. E., Labocha, S., Angioni, C., Thomas, D., Ferreiros, N., Looso, M., Pullamsetti, S. S., Geisslinger, G. Steinhilber, D., Brandes, R. P., Leisegang, M. S.: PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells. Acta Physiologica 2018 (2016) No. 1: 13-27 (http://doi.org/10.1111/apha.12700)

Kemmerer, M., Wittig, I., Richter, F., Brüne, B., Namgaladze, D.: AMPK activates LXRa and ABCA1 expression in human macrophages. The International Journal of Biochemistry & Cell Biology (2016) No. 78: 1-9 (http://doi.org/10.1016/j.biocel.2016.06.014)

King-Himmelreich, T.S., Schramm, S., Wolters, M.C., Schmetzer, J., Moser, C.V., Knothe, C., Resch, E., Peil, J., Geisslinger, G., Niederberger, E.: The impact of endurance exercise on global and AMPK gene-specific DNA methylation. Biochemical and Biophysical Research Communications 474 (2016) No. 2: 284-290 (http://doi.org/10.1016/j.bbrc.2016.04.078)

Klemmt, P.A., Resch, E., Smyrek, I., Engels, K., Stelzer, E.H., Starzinski-Powitz, A.: Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile. Biology Open 15 (2016) No. 5(11), 1607-1619 (http://doi.org/10.1242/bio.019463)

Klingler, F.M., Wolf, M., Wittmann, S., Gribbon, P., Proschak, E.: Bacterial expression and HTS assessment of soluble epoxide hydrolase phosphatase. Journal of Biomolecular Screening (2016) No. 7: 689-94 (http://doi.org/10.1177/1087057116637609)

Knothe, C., Shiratori, H., Resch, E., Ultsch, A., Geisslinger, G., Doehring, A., Lotsch, J.: Disagreement between two common biomarkers of global DNA methylation. Clinical Epigenetics 8 (2016) 60 (http://doi.org/10.1186/s13148-016-0227-0)

Knothe, C., Oertel, B. G., Ultsch, A., Kettner, M., Schmidt, P. H., Wunder, C., Toennes, S. W., Geisslinger, G., Lotsch, J.: Pharmacoepigenetics of the role of DNA methylation in mu-opioid receptor expression in different human brain regions. Epigenomics 8 (2016) No. 12: 1583- 1599 (http://doi.org/10.2217/epi-2016-0072)

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Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G., Schachner, M.: Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions. Journal of Neurochemistry (2016) No. 136(1): 48-62 (http://doi.org/10.1111/jnc.13383)

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