Climate change and intensive agriculture are promoting the spread of insect pests. At the same time, conventional insecticides are coming under pressure due to environmental and health risks and increasing resistance. With Calantha® (active ingredient: ledprona), GreenLight Biosciences has obtained approval in the USA in 2023 for the world's first RNAi spray. A recent study by GreenLight Biosciences, the Fraunhofer Institute for Molecular Biology and Applied Ecology IME (Bioresources Division) and Justus Liebig University Giessen explains the mechanism of action. The spray specifically switches off a vital gene in the Colorado potato beetle and also triggers a previously undescribed secondary effect, which leads to a lethal accumulation of proteins in the insect's body. The study demonstrates the specificity of the dsRNA and identifies the subsequent proteasome malfunction caused by the downregulation as the mechanism of action of ledprona.
more info
Fraunhofer Institute for Molecular Biology and Applied Ecology IME