Novel protein-based sugar substitutes with improved gustatory and processing properties

Research project - Novel Sweets

Motivation and problem definition

© Fraunhofer IME | Maria Stroot

In recent decades, not only has sugar consumption continuously increased, but the number of chronic diseases attributable to excessive sugar consumption has also risen sharply worldwide. Diseases such as tooth decay, high blood pressure, cardiovascular diseases (stroke and heart attack), type 2 diabetes, and overweight and obesity in children and adults are caused or promoted by long-term sugar consumption. To counteract the increasing health problems caused by diet, the German Federal Ministry of Agriculture and Food (BMEL) aims to reduce the sugar content in convenience foods and beverages in order to lower the direct and indirect costs for the economy and society as a whole. Sweet-tasting proteins, isolated for the first time from tropical and African plants, can serve as a template for developing healthier alternatives to sugar and counteracting diet-related diseases.

Project goals and solution approach

© Fraunhofer IME | Nadja Pietschmann

Within the framework of innovation funding from the BMEL, Fraunhofer IME is researching, in the “Novel Sweets” project together with the metaX Institute for Dietetics and the company candidum, innovative protein-based sweeteners. These represent a healthier alternative to sugar and sugar substitutes and can be used in processed foods. Through computer-aided optimization of protein sequences and in silico modeling, the limited chemical and process-related properties of these sweeteners are to be improved. This includes increased temperature stability, enhanced pH stability, and improved sensory properties without unwanted aftertaste or lingering flavor. The optimized product candidates are to be produced biotechnologically via microbial fermentation and used both in the products of the project partners and in soft drinks.

Project profile

Project title Novel Sweets: Novel protein-based sugar substitutes with improved gustatory and processing properties
Duration 09/2020 – 09/2023
Promotion

Federal Ministry of Agriculture and Food (BMEL)

Funding ca. 1.8 Mio. Euro 
Consortium
  • Fraunhofer Institute for Molecular Biology and Applied Ecology IME (Coordinator)
  • metaX Institut für Diätetik GmbH
  • candidum GmbH
Project leader Dr. Stefan Rasche

Goals 

 

  • Development of novel sweet-tasting proteins with improved product and process properties
  • Process development of a cost-effective manufacturing process
  • Creation of the approval requirements for a protein-based sweetener as a novel food or food additive

»Wie süß können Proteine sein?«

Interview mit Dr. Stefan Rasche im Magazin Forschungsfelder (2, 2023)

»Proteinbasierte Süßungsmittel als Zuckerersatz«

Pressemitteilung in Forschung Kompakt (Dez. 2024)

»Süße Versuchung«

Beitrag zu NovelSweets im Fraunhofer-Magazin (4/2024)

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Stefan Rasche

Contact Press / Media

Dr. Stefan Rasche

Head of Department »Precision Fermentation«

Fraunhofer Institute for Molecular Biology and Applied Ecology IME
Forckenbeckstr. 6
52074 Aachen

Phone +49 241 6085-196