Continuous photochemically assisted biocatalysis for the synthesis of fine chemicals

Fine chemicals are an essential building block in the chemical industry, which serves the pharmaceutical and agrochemical markets. However, the chemical industry faces the challenge of finding cost-effective, sustainable, and flexible production methods to meet the growing demand for fine chemicals. Currently, these syntheses are often carried out in batch processes, which require long changeover times and complex process controls. Therefore, there is a need for new technologies that enable continuous production while increasing efficiency and sustainability. 

In the BioLIGHT project, the four Fraunhofer Institutes collaborated in the field of cascade reactions to establish the development of a modular technology and process platform for the continuous photochemically assisted biocatalysis of fine chemicals. The solution approach includes the production of novel hybrid catalysts, the combination of microprocess engineering for process control, and implementation in a multifunctional synthesis plant.

Fraunhofer IME's role in the project includes, in particular, the development, optimization, production, and immobilization of customized biocatalysts. The continuous synthesis of chemical building blocks for fine chemicals, e.g., chiral alcohols with high purity and yield, was to be demonstrated.