MykoNANO

Rapid Detection of Mycotoxins in Agriculture Products Based on Nanoparticles

Rapid Detection of Mycotoxins in Agriculture Products Based on Nanoparticles
© Fraunhofer IME | Florian Schröper, Jan Pietschmann

Mycotoxins represent a significant health risk for humans and animals and cause considerable financial losses for food processing companies. According to estimates, 25% of all food products are contaminated with toxic products of molds. Within the MykoNANO project, the Fraunhofer Institute for Molecular Biology and Applied Ecology IME in Aachen, in collaboration with the company GeneCon International GmbH and the Institute of Complex Systems (ICS-8) at Research Center Juelich, is developing an innovative rapid test for the detection of various mycotoxins in grain and milk products.

This rapid test is based on magnetic immunodetection, at which monoclonal antibodies are bound to magnetic nanoparticles and thus can specifically bind to the toxins. Using a multiplex approach, a large number of toxins can be trapped within a sample. Magnetic separation of the nanoparticles out of the sample enables concentration of the mycotoxin-nanoparticle-complexes and a subsequent high sensitive detection by a portable reader. With a newly developed smartphone app, the user is guided through sample processing and the resulting data are documented and saved. This enables a quick and in-place clarification if the food product is free from contaminations.

Project Duration

01.12.2018-30.11.2021

Project Partners

GeneCon International GmbH

Institute of Complex Systems, Bioelektronik (ICS-8), Forschungszentrum Jülich GmbH

Funding

This project is funded by the European Union and the State of North Rhine-Westphalia.

Paper

Pietschmann, J.; Dittmann, D.; Spiegel, H.; Krause, H.-J. and Schröper F. A Novel Method for Antibiotic Detection in Milk Based on Competitive Magnetic Immunodetection (2020) Foods, 12, 1773.

https://doi.org/10.3390/foods9121773

Pietschmann, J.; Spiegel, H.; Krause, H.-J.; Schillberg, S.; Schröper, F. Sensitive Aflatoxin B1 Detection Using Nanoparticle-Based Competitive Magnetic Immunodetection (2020) Toxins, 12, 337.

https://doi.org/10.3390/toxins12050337