Selected Publications Molecular Biology

 

We would like to give you an impression of the Molecular Biology Division's published research findings. So please find below annual lists of selected papers, starting in 2014.

Molecular Biology Division

For complete annual publication lists starting in 2009, please take a look at our annual reports (from 2015 at the annex facts).

For specific research and complete annual publication lists of the Fraunhofer IME since 1964, you can use the publication database "Fraunhofer IME-Publica".

Juli 2016 aktualisiert

Addai-Mensah, O., Seidel, M., Amidu, N., Maskus, D.J., Kapelski, S., Breuer, G., Franken, C., Owusu-Dabo, E., Frempong, M., Rakotozandrindrainy, R., Schinkel, H., Reimann, A., Klockenbring, T., Barth, S., Fischer, R., Fendel, R., 2016. Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria. Malar. J. 15, 65. http://doi.org/10.1186/s12936-016-1112-1

Amoury, M., Kolberg, K., Pham, A.-T., Hristodorov, D., Mladenov, R., Di Fiore, S., Helfrich, W., Kiessling, F., Fischer, R., Pardo, A., Thepen, T., Hussain, A.F., Nachreiner, T., Barth, S., 2016a. Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model. Cancer Lett. 372, 201–209. http://doi.org/10.1016/j.canlet.2016.01.027

Amoury, M., Mladenov, R., Nachreiner, T., Pham, A.-T., Hristodorov, D., Di Fiore, S., Helfrich, W., Pardo, A., Fey, G., Schwenkert, M., Thepen, T., Kiessling, F., Hussain, A.F., Fischer, R., Kolberg, K., Barth, S., 2016b. A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein. Int. J. Cancer 139, 916–927. http://doi.org/10.1002/ijc.30119

Arfi, Z.A., Hellwig, S., Drossard, J., Fischer, R., Buyel, J.F., 2016. Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins. Biotechnology Journal 11, 507–518. http://doi.org/10.1002/biot.201500271

Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, J., Bernal-Delgado, E., Blomberg, N., Bock, C., Conesa, A., Del Signore, S., Delogne, C., Devilee, P., Di Meglio, A., Eijkemans, M., Flicek, P., Graf, N., Grimm, V., Guchelaar, H.-J., Guo, Y.-K., Gut, I.G., Hanbury, A., Hanif, S., Hilgers, R.-D., Honrado, Á., Hose, D.R., Houwing-Duistermaat, J., Hubbard, T., Janacek, S.H., Karanikas, H., Kievits, T., Kohler, M., Kremer, A., Lanfear, J., Lengauer, T., Maes, E., Meert, T., Müller, W., Nickel, D., Oledzki, P., Pedersen, B., Petkovic, M., Pliakos, K., Rattray, M., i Màs, J.R., Schneider, R., Sengstag, T., Serra-Picamal, X., Spek, W., Vaas, L.A.I., van Batenburg, O., Vandelaer, M., Varnai, P., Villoslada, P., Vizcaíno, J.A., Wubbe, J.P.M., Zanetti, G., 2016. Making sense of big data in health research: Towards an EU action plan. Genome Medicine 8, 71. http://doi.org/10.1186/s13073-016-0323-y

Barthelmes, J., Tafferner, N., Kurz, J., de Bruin, N., Parnham, M.J., Geisslinger, G., Schiffmann, S., 2016. Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues. J Vis Exp. http://doi.org/10.3791/53933

Beyer, S., Xie, L., Schmidt, M., de Bruin, N., Ashtikar, M., Rüschenbaum, S., Lange, C.M., Vogel, V., Mäntele, W., Parnham, M.J., Wacker, M.G., 2016. Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques. J Control Release 235, 352–364. http://doi.org/10.1016/j.jconrel.2016.06.013

Bialon, M., Grezella, C., Friesen, L., Sieben, T., Pham, A.-T., Fischer, R., Barth, S., Püttmann, C., Stein, C., 2016. A Monoclonal Antibody That Discriminates Between SNAP-Tagged and CLIP-Tagged Proteins. Monoclon Antib Immunodiagn Immunother 35, 141–147. http://doi.org/10.1089/mab.2016.0002

Bodewein, L., Schmelter, F., Di Fiore, S., Hollert, H., Fischer, R., Fenske, M., 2016. Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines. Toxicol. Appl. Pharmacol. 305, 83–92. http://doi.org/10.1016/j.taap.2016.06.008

Boes, A., Spiegel, H., Kastilan, R., Bethke, S., Voepel, N., Chudobová, I., Bolscher, J.M., Dechering, K.J., Fendel, R., Buyel, J.F., Reimann, A., Schillberg, S., Fischer, R., 2016. Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail. Malar J 15. http://doi.org/10.1186/s12936-016-1328-0

Borsari, C., Luciani, R., Pozzi, C., Pöhner, I., Henrich, S., Trande, M., Cordeiro-da-Silva, A., Santarém, N., Baptista, C., Tait, A., Di Pisa, F., Dello Iacono, L., Landi, G., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Gribbon, P., Kohler, M., Keminer, O., Behrens, B., Costantino, L., Tejera Nevado, P., Bifeld, E., Eick, J., Clos, J., Torrado, J., Jiménez-Antón, M.D., Corral, M.J., Alunda, J.M., Pellati, F., Wade, R.C., Ferrari, S., Mangani, S., Costi, M.P., 2016. Profiling of flavonol derivatives for the development of anti-trypanosomatidic drugs. J. Med. Chem. http://doi.org/10.1021/acs.jmedchem.6b00698

Brändl, B., Schuldt, B.M., Böhnke, L., Keminer, O., Vaas, L.A.I., Fischer, R., Müller, F.-J., Pless, O., 2016. Utilizing Regulatory Networks for Pluripotency Assessment in Stem Cells. Curr Stem Cell Rep 1–8. http://doi.org/10.1007/s40778-016-0054-4

Brenke, J.K., Salmina, E.S., Ringelstetter, L., Dornauer, S., Kuzikov, M., Rothenaigner, I., Schorpp, K., Giehler, F., Gopalakrishnan, J., Kieser, A., Gul, S., Tetko, I.V., Hadian, K., 2016. Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase–Glutathione Interaction. J Biomol Screen 21, 596–607. http://doi.org/10.1177/1087057116639992

Brenneis, M., Aghajaanpour, R., Knape, T., Sha, L.K., Neb, H., Meybohm, P., Zacharowski, K., Hauser, I.A., Büttner, S., Parnham, M.J., Brüne, B., von Knethen, A., 2016. Pparγ Expression in T Cells as a Prognostic Marker of Sepsis. Shock 45, 591–597. http://doi.org/10.1097/SHK.0000000000000568

Buyel, J., Twyman, R.M., Fischer, R., 2016. Very-large-scale Production of Monoclonal Antibodies in Plants, in: Gottschalk, U. (Ed.), Process Scale Purification of Antibodies. Wiley-Interscience.

Buyel, J.F., 2016. Numeric simulation can be used to predict heat transfer during the blanching of leaves and intact plants. Biochemical Engineering Journal 109, 118–126. http://doi.org/10.1016/j.bej.2016.01.009

Buyel, J.F., 2016. Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts. J Vis Exp. http://doi.org/10.3791/53940

Buyel, J.F., Hubbuch, J., Fischer, R., 2016. Comparison of Tobacco Host Cell Protein Removal Methods by Blanching Intact Plants or by Heat Treatment of Extracts. J Vis Exp. http://doi.org/10.3791/54343

Buyel, J.F., Gruchow, H.M., Tödter, N., Wehner, M., 2016. Determination of the thermal properties of leaves by non-invasive contact‑free laser probing. J. Biotechnol. 217, 100–108. http://doi.org/10.1016/j.jbiotec.2015.11.008

de Bruin, N.M.W.J., Schmitz, K., Schiffmann, S., Tafferner, N., Schmidt, M., Jordan, H., Häußler, A., Tegeder, I., Geisslinger, G., Parnham, M.J., 2016. Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behav. Brain Res. 300, 160–174. http://doi.org/10.1016/j.bbr.2015.12.006

Drebes, J., Künz, M., Windshügel, B., Kikhney, A.G., Müller, I.B., Eberle, R.J., Oberthür, D., Cang, H., Svergun, D.I., Perbandt, M., Betzel, C., Wrenger, C., 2016. Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus – Insights into a novel pro-drug approach addressing MRSA infections. Scientific Reports 6, 22871. http://doi.org/10.1038/srep22871

Ellinger, B., Gribbon, P., 2016. Risk mitigation in academic drug discovery. Expert Opinion on Drug Discovery 11, 333–336. http://doi.org/10.1517/17460441.2016.1152257

Frenz, T., Grabski, E., Buschjäger, D., Vaas, L.A.I., Burgdorf, N., Schmidt, R.E., Witte, T., Kalinke, U., 2016. CD4+ T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. Journal of Allergy and Clinical Immunology. http://doi.org/10.1016/j.jaci.2016.04.013

Fritsch, L., Soeur, R., Hansen, C., Fischer, R., Schillberg, S., Schröper, F., 2016. Next-generation sequencing of amplicons is a rapid and reliable method for the detection of polymorphisms relevant for barley breeding. Mol Breeding 36, 1–9. http://doi.org/10.1007/s11032-016-0507-6

Hanke, T., Merk, D., Steinhilber, D., Geisslinger, G., Schubert-Zsilavecz, M., 2016. Small molecules with anti-inflammatory properties in clinical development. Pharmacol. Ther. 157, 163–187. http://doi.org/10.1016/j.pharmthera.2015.11.011

Hauser, A.S., Windshügel, B., 2016. LEADS-PEP: A Benchmark Data Set for Assessment of Peptide Docking Performance. J. Chem. Inf. Model. 56, 188–200. http://doi.org/10.1021/acs.jcim.5b00234

Hristodorov, D., Mladenov, R., Fischer, R., Barth, S., Thepen, T., 2016. Fully human MAP-fusion protein selectively targets and eliminates proliferating CD64(+) M1 macrophages. Immunol. Cell Biol. 94, 470–478. http://doi.org/10.1038/icb.2016.4

King-Himmelreich, T.S., Schramm, S., Wolters, M.C., Schmetzer, J., Möser, C.V., Knothe, C., Resch, E., Peil, J., Geisslinger, G., Niederberger, E., 2016. The impact of endurance exercise on global and AMPK gene-specific DNA methylation. Biochem. Biophys. Res. Commun. 474, 284–290. http://doi.org/10.1016/j.bbrc.2016.04.078

Klingler, F.-M., Wolf, M., Wittmann, S., Gribbon, P., Proschak, E., 2016. Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase. J Biomol Screen 1087057116637609. http://doi.org/10.1177/1087057116637609

Klose, D., Saunders, U., Barth, S., Fischer, R., Jacobi, A.M., Nachreiner, T., 2016. Novel fusion proteins for the antigen-specific staining and elimination of B cell receptor-positive cell populations demonstrated by a tetanus toxoid fragment C (TTC) model antigen. BMC Biotechnol. 16, 18. http://doi.org/10.1186/s12896-016-0249-x

Knothe, C., Shiratori, H., Resch, E., Ultsch, A., Geisslinger, G., Doehring, A., Lötsch, J., 2016. Disagreement between two common biomarkers of global DNA methylation. Clin Epigenetics 8, 60. http://doi.org/10.1186/s13148-016-0227-0

Kringel, D., Ultsch, A., Zimmermann, M., Jansen, J.-P., Ilias, W., Freynhagen, R., Griessinger, N., Kopf, A., Stein, C., Doehring, A., Resch, E., Lötsch, J., 2016. Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses. Pharmacogenomics J. http://doi.org/10.1038/tpj.2016.28

Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G., Schachner, M., 2016. Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions. J. Neurochem. 136, 48–62. http://doi.org/10.1111/jnc.13383

Maculins, T., Carter, N., Dorval, T., Hudson, K., Nissink, J.W.M., Hay, R.T., Alwan, H., 2016a. A Generic Platform for Cellular Screening Against Ubiquitin Ligases. Sci Rep 6, 18940. http://doi.org/10.1038/srep18940

Maculins, T., Fiskin, E., Bhogaraju, S., Dikic, I., 2016b. Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res. 26, 499–510. http://doi.org/10.1038/cr.2016.30

Mandal, M.K., Ahvari, H., Schillberg, S., Schiermeyer, A., 2016. Tackling Unwanted Proteolysis in Plant Production Hosts Used for Molecular Farming. Front. Plant Sci. 267. http://doi.org/10.3389/fpls.2016.00267

Menzel, S., Holland, T., Boes, A., Spiegel, H., Bolzenius, J., Fischer, R., Buyel, J.F., 2016. Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two Plant-Derived Malaria Vaccine Candidates. Front Plant Sci 7, 159. http://doi.org/10.3389/fpls.2016.00159

Mora, J., Schlemmer, A., Wittig, I., Richter, F., Putyrski, M., Frank, A.-C., Han, Y., Jung, M., Ernst, A., Weigert, A., Brüne, B., 2016. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol. http://doi.org/10.1093/jmcb/mjw006

Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Schäfers, C., Teigeler, M., Fenske, M., 2016. Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test. Aquat. Toxicol. 176, 116–127. http://doi.org/10.1016/j.aquatox.2016.04.018

Niesen, J., Hehmann-Titt, G., Woitok, M., Fendel, R., Barth, S., Fischer, R., Stein, C., 2016a. A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor. Cancer Lett. 374, 229–240. http://doi.org/10.1016/j.canlet.2016.02.020

Niesen, J., Sack, M., Seidel, M., Fendel, R., Barth, S., Fischer, R., Stein, C., 2016b. SNAP-tag technology: a useful tool to determine affinity constants and other functional parameters of novel antibody fragments. Bioconjug. Chem. http://doi.org/10.1021/acs.bioconjchem.6b00315

Rasche, S., Herwartz, D., Schuster, F., Jablonka, N., Weber, A., Fischer, R., Schillberg, S., 2016. More for less: Improving the biomass yield of a pear cell suspension culture by design of experiments. Sci Rep 6. http://doi.org/10.1038/srep23371

Rees, S., Gribbon, P., Birmingham, K., Janzen, W.P., Pairaudeau, G., 2016. Towards a hit for every target. Nat Rev Drug Discov 15, 1–2. http://doi.org/10.1038/nrd.2015.19

Roos, J., Grösch, S., Werz, O., Schröder, P., Ziegler, S., Fulda, S., Paulus, P., Urbschat, A., Kühn, B., Maucher, I., Fettel, J., Vorup-Jensen, T., Piesche, M., Matrone, C., Steinhilber, D., Parnham, M.J., Maier, T.J., 2016. Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? Pharmacol. Ther. 157, 43–64. http://doi.org/10.1016/j.pharmthera.2015.11.001

Schinkel, H., Schillberg, S., 2016. Genome editing: intellectual property and product development in plant biotechnology. Plant Cell Rep. 35, 1487–1491. http://doi.org/10.1007/s00299-016-1988-9

Schneider, K., Schiermeyer, A., Dolls, A., Koch, N., Herwartz, D., Kirchhoff, J., Fischer, R., Russell, S.M., Cao, Z., Corbin, D.R., Sastry-Dent, L., Ainley, W.M., Webb, S.R., Schinkel, H., Schillberg, S., 2016. Targeted gene exchange in plant cells mediated by a zinc finger nuclease double cut. Plant Biotechnol. J. 14, 1151–1160. http://doi.org/10.1111/pbi.12483

Schröder, M., Kolodzik, A., Windshügel, B., Krepstakies, M., Priyadarshini, P., Hartjen, P., van Lunzen, J., Rarey, M., Hauber, J., Meier, C., 2016. Linker-Region Modified Derivatives of the Deoxyhypusine Synthase Inhibitor CNI-1493 Suppress HIV-1 Replication. Arch. Pharm. Chem. Life Sci. 349, 91–103. http://doi.org/10.1002/ardp.201500323

Sisignano, M., Parnham, M.J., Geisslinger, G., 2016. Drug Repurposing for the Development of Novel Analgesics. Trends Pharmacol. Sci. 37, 172–183. http://doi.org/10.1016/j.tips.2015.11.006

Tafferner, N., Barthelmes, J., Eberle, M., Ulshöfer, T., Henke, M., deBruin, N., Mayer, C.A., Foerch, C., Geisslinger, G., Parnham, M.J., Schiffmann, S., 2016. Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. Eur. J. Immunol. 46, 570–581. http://doi.org/10.1002/eji.201545782

Thom, V., Schmid, S., Gelderblom, M., Hackbusch, R., Kolster, M., Schuster, S., Thomalla, G., Keminer, O., Pleß, O., Bernreuther, C., Glatzel, M., Wegscheider, K., Gerloff, C., Magnus, T., Tolosa, E., 2016. IL-17 production by CSF lymphocytes as a biomarker for cerebral vasculitis. Neurol Neuroimmunol Neuroinflamm 3, e214. http://doi.org/10.1212/NXI.0000000000000214

Vasilev, N., Smales, C.M., Schillberg, S., Fischer, R., Schiermeyer, A., 2016. Developments in the production of mucosal antibodies in plants. Biotechnol. Adv. 34, 77–87. http://doi.org/10.1016/j.biotechadv.2015.11.002

von Felbert, V., Bauerschlag, D., Maass, N., Bräutigam, K., Meinhold-Heerlein, I., Woitok, M., Barth, S., Hussain, A.F., 2016. A specific photoimmunotheranostics agent to detect and eliminate skin cancer cells expressing EGFR. J. Cancer Res. Clin. Oncol. 142, 1003–1011. http://doi.org/10.1007/s00432-016-2122-7

Wegner, M.-S., Schiffmann, S., Parnham, M.J., Geisslinger, G., Grösch, S., 2016. The enigma of ceramide synthase regulation in mammalian cells. Prog. Lipid Res. 63, 93–119. http://doi.org/10.1016/j.plipres.2016.03.006

 

Behrens, F., Tak, P.P., Østergaard, M., Stoilov, R., Wiland, P., Huizinga, T.W., Berenfus, V.Y., Vladeva, S., Rech, J., Rubbert-Roth, A., Korkosz, M., Rekalov, D., Zupanets, I.A., Ejbjerg, B.J., Geiseler, J., Fresenius, J., Korolkiewicz, R.P., Schottelius, A.J., Burkhardt, H., 2015. MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial. Ann. Rheum. Dis. 74, 1058–1064. http://doi.org/10.1136/annrheumdis-2013-204816

Beiss, V., Spiegel, H., Boes, A., Kapelski, S., Scheuermayer, M., Edgue, G., Sack, M., Fendel, R., Reimann, A., Schillberg, S., Pradel, G., Fischer, R., 2015a. Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein. Biotechnol. Bioeng. 112, 1297–1305. http://doi.org/10.1002/bit.25548

Beiss, V., Spiegel, H., Boes, A., Scheuermayer, M., Reimann, A., Schillberg, S., Fischer, R., 2015b. Plant expression and characterization of the transmission-blocking vaccine candidate PfGAP50. BMC Biotechnology 15, 108. http://doi.org/10.1186/s12896-015-0225-x

Beyer, S., Moosmann, A., Kahnt, A.S., Ulshöfer, T., Parnham, M.J., Ferreirós, N., Wagner, S., Wacker, M.G., 2015. Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox. Pharm. Res. 32, 3986–3998. http://doi.org/10.1007/s11095-015-1759-2

Boes, A., Spiegel, H., Edgue, G., Kapelski, S., Scheuermayer, M., Fendel, R., Remarque, E., Altmann, F., Maresch, D., Reimann, A., Pradel, G., Schillberg, S., Fischer, R., 2015a. Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits. Plant Biotechnol J 13, 222–234. http://doi.org/10.1111/pbi.12255

Boes, A., Spiegel, H., Voepel, N., Edgue, G., Beiss, V., Kapelski, S., Fendel, R., Scheuermayer, M., Pradel, G., Bolscher, J.M., Behet, M.C., Dechering, K.J., Hermsen, C.C., Sauerwein, R.W., Schillberg, S., Reimann, A., Fischer, R., 2015b. Analysis of a Multi-component Multi-stage Malaria Vaccine Candidate--Tackling the Cocktail Challenge. PLoS ONE 10, e0131456. http://doi.org/10.1371/journal.pone.0131456

Bortesi, L., Fischer, R., 2015. The CRISPR/Cas9 system for plant genome editing and beyond. Biotechnology Advances 33, 41–52. http://doi.org/10.1016/j.biotechadv.2014.12.006

Brändl, B., Schneider, S.A., Loring, J.F., Hardy, J., Gribbon, P., Müller, F.-J., 2015. Stem cell reprogramming: basic implications and future perspective for movement disorders. Mov. Disord. 30, 301–312. http://doi.org/10.1002/mds.26113

Brehm, H., Hristodorov, D., Pardo, A., Mladenov, R., Niesen, J., Fischer, R., Tur, M.K., Barth, S., 2015. Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein. Cancer Lett. 365, 149–155. http://doi.org/10.1016/j.canlet.2015.04.004

Buntru, M., Vogel, S., Stoff, K., Spiegel, H., Schillberg, S., 2015. A versatile coupled cell-free transcription–translation system based on tobacco BY-2 cell lysates. Biotechnol. Bioeng. 112, 867–878. http://doi.org/10.1002/bit.25502

Buyel, J.F., 2015. Controlling the interplay between Agrobacterium tumefaciens and plants during the transient expression of proteins. Bioengineered 6, 242–244. http://doi.org/10.1080/21655979.2015.1052920

Buyel, J.F., 2015. Process Development Strategies in Plant Molecular Farming. Curr Pharm Biotechnol 16, 966–982. http://doi.org/10.2174/138920101611150902115413

Buyel, J.F., Buyel, J.J., Haase, C., Fischer, R., 2015a. The impact of Pseudomonas syringae type III effectors on transient protein expression in tobacco. Plant Biol (Stuttg) 17, 484–492. http://doi.org/10.1111/plb.12264

Buyel, J.F., Gruchow, H.M., Fischer, R., 2015. Depth Filters Containing Diatomite Achieve More Efficient Particle Retention than Filters Solely Containing Cellulose Fibers. Front Plant Sci 6, 1134. http://doi.org/10.3389/fpls.2015.01134

Buyel, J.F., Twyman, R.M., Fischer, R., 2015b. Extraction and downstream processing of plant-derived recombinant proteins. Biotechnol. Adv. 33, 902–913. http://doi.org/10.1016/j.biotechadv.2015.04.010

Cheng, X., Dimou, E., Alborzinia, H., Wenke, F., Göhring, A., Reuter, S., Mah, N., Fuchs, H., Andrade-Navarro, M.A., Adjaye, J., Gul, S., Harms, C., Utikal, J., Klipp, E., Mrowka, R., Wölfl, S., 2015a. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J. Med. Chem. 58, 4976–4983. http://doi.org/10.1021/acs.jmedchem.5b00144

Cheng, X., Yoshida, H., Raoofi, D., Saleh, S., Alborzinia, H., Wenke, F., Göhring, A., Reuter, S., Mah, N., Fuchs, H., Andrade-Navarro, M.A., Adjaye, J., Gul, S., Utikal, J., Mrowka, R., Wölfl, S., 2015b. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J. Med. Chem. 58, 5742–5750. http://doi.org/10.1021/acs.jmedchem.5b00226

Cremer, C., Vierbuchen, T., Hein, L., Fischer, R., Barth, S., Nachreiner, T., 2015. Angiogenin mutants as novel effector molecules for the generation of fusion proteins with increased cytotoxic potential. J. Immunother. 38, 85–95. http://doi.org/10.1097/CJI.0000000000000053

Epping, J., van Deenen, N., Niephaus, E., Stolze, A., Fricke, J., Huber, C., Eisenreich, W., Twyman, R.M., Prüfer, D., Schulze Gronover, C., 2015. A rubber transferase activator is necessary for natural rubber biosynthesis in dandelion. Nature Plants 1, 15048. http://doi.org/10.1038/nplants.2015.48

Faber, B.W., Hellwig, S., Houard, S., Havelange, N., Drossard, J., Mertens, H., Croon ,A., Byrne, R., van der Werff, N., van der Eijk, M., Thomas, A.W., Kocken, C.H.M. and Remarque, E.J.: Production, quality control, stability and pharmacotoxicity of a mixture of three cGMP-produced Diversity Covering Plasmodium falciparum AMA1 proteins, submitted

Fritsch, L., Fischer, R., Wambach, C., Dudek, M., Schillberg, S., Schröper, F., 2015. Next-generation sequencing is a robust strategy for the high-throughput detection of zygosity in transgenic maize. Transgenic Res. 24, 615–623. http://doi.org/10.1007/s11248-015-9864-x

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