Pharmaceutical Technology and Nanosciences

In recent years, nanotechnology has emerged as a global industry. Nanocrystals and nanocarriers have been utilized to increase the bioavailability of poorly soluble API or to delivery drug substances to a specific site of action. Translating these approaches into new drug products has been a challenge to the existing technologies.

We offer nanocarrier and nanocrystal technology, in vitro release testing of nanosized formulations and physiology-based pharmacokinetic (PBPK) models for predicting the in vivo performance of nanoformulations (IVIVC).

Formulation development

  • Feasibility studies and formulation development for drugs and drug candidates
  • Optimization of the in vitro release profile of micro- and nanoformulations
  • Selection of process parameters for nanocarrier synthesis and scale-up
  • Selection of specification ranges
  • Biorelevant in vitro release tests for nanoformulations

Technologies for synthesis

  • Continuous flow nanoprecipitation
  • Hot Melt Extrusion
  • Nanomilling
  • Self-assembling systems
  • SNEDDS, SMEDDS, liposomes

Analytical technologies

  • Dispersion releaser technology
  • Particle size characterization
  • In vitro release models for nanomedicines and medical devices
  • In vitro digestion models for nanomaterials
  • Exposure models for nanomaterials

Selected Publications

Beyer S, Xie L, Schmidt M, deBruin N, Vogel V, Parnham MJ, Mäntele W, Wacker MG (2016); Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques, J. Control. Release, Epub ahead of print

Wacker MG, Proykova A, Santos GM (2016); Dealing with nanosafety around the globe – Regulation vs. Innovation, Int. J. Pharm. 509 (1-2): 95-106

Villa Nova M, Janas C, Schmidt M, Ulshöfer T, Gräfe S, Schiffmann S, de Bruin N, Wiehe A, Albrecht V, Parnham MJ, Bruschi ML, Wacker MG (2015); Nanocarriers for photodynamic therapy - Rational formulation design and medium-scale manufacture, Int. J. Pharm. 491(1-2): 250-260

Beyer S, Xie L, Graefe S, Vogel V, Dietrich K, Wiehe A, Albrecht V, Maentele W, Wacker MG (2015); Bridging Laboratory and Large Scale Production: Preparation and In Vitro-Evaluation of Photosensitizer-Loaded Nanocarrier Devices for Targeted Drug Delivery, Pharm. Res. 32(5): 1714-1726