Translational Drug Validation and Preclinical Disease Models

State-of-the art technology is utilized for molecular and cellular investigations on gene expression and modulation, cell signalling, mediator generation and cell surface receptor function, particularly in relation to immune responses. Novel assays are established and used to test compounds from the drug discovery unit and for compound screening at IME-Screening Port. Knockout technologies are standard tools in animal and zebra fish studies and whole animal test systems are developed using multiple outcome measures, including bioimaging, which facilitate translation to the patient. Novel antibodies and peptides are generated for therapeutic testing, as well as biomarker development, together with the analytical business unit.