Resolution of Inflammation

A further research focus deals with the molecular, cellular and genetic aspects of the resolution of inflammatory and autoimmune diseases, such as arthritis, psoriasis, systemic sclerosis and liver disease. A particular emphasis is laid on lipid and redox mediators as well as on endogenous immunoregulatory mechanisms and ubiquitin signaling. Current projects are directed towards the development of novel anti-inflammatory biological agents. In the area of clinical research, we are concentrating on the treatment of rheumatoid arthritis, psoriasis and other (auto)immune diseases.

Mora J, Schlemmer A, Wittig I, Richter F, Putyrski M, Frank AC, Han Y, Jung M, Ernst A, Weigert A, Brüne B (2016) Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol. 2016 Feb 17. pii: mjw006. [Epub ahead of print]

Homann J, Suo J, Schmidt M, de Bruin N, Scholich K, Geisslinger G, Ferreirós N (2015) In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse. PLoS One. 2015 Nov 23;10(11):e0143141. doi: 10.1371/journal.pone.0143141.

Homann J, Lehmann C, Kahnt AS, Steinhilber D, Parnham MJ, Geisslinger G, Ferreirós N (2014) Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators. J Chromatogr A. 2014 Sep 19;1360:150-63.