Biobanking

In order to improve the development of new diagnostic procedures and therapies in the indication area of immune-mediated and inflammatory diseases (such as rheumatoid arthritis, psoriatic arthritis and systemic sclerosis), biomaterials are collected and stored in the biobank of and the research division Translational Medicine of Fraunhofer IME. These samples can be  provided to internal and external cooperation partners for defined research projects. A specifically developed documentation system provides the ideal basis for the detailed recording of the clinical phenotype and the classification of the clinical picture. These data can thus be provided together with the biomaterial sample for subsequent analyses.

 

 

Biomaterial collection from patients with immune-mediated and inflammatory diseases

Collection of biomaterial samples (blood, skin, stool, urine) from the outpatient departments of the University Hospital Frankfurt, especially from the indication areas dermatology and rheumatology.

© Uli Planz, Fraunhofer CIMD
© Uli Planz, Fraunhofer CIMD
© Uli Planz, Fraunhofer CIMD

Löhr S, Ekici AB, Uebe S, Büttner C, Köhm M, Behrens F, Böhm B, Sticherling M, Schett G, Simon D, Mössner R, Nimeh A, Oji V, Assmann G, Rech J, Holmdahl R, Burkhardt H, Reis A, Hüffmeier U. Analyses of association of psoriatic arthritis and psoriasis vulgaris with functional NCF1 variants. Rheumatology (Oxford). 2019 Feb 7. doi: 10.1093/rheumatology/key448.

Mojtahed Poor S, Ulshöfer T, Gabriel LA, Henke M, Köhm M, Behrens F, Geisslinger G, Parnham MJ, Burkhardt H, Schiffmann S. Immunogenicity assay development and validation for biological therapy as exemplified by ustekinumab. Clin Exp Immunol. 2019 Jan 17. doi: 10.1111/cei.13261.

Wagner A, Köhm M, Nordin A, Svenungsson E, Pfeilschifter JM, Radeke HH. Increased Serum Levels of the IL-33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis. Scand J Immunol. 2015 Sep;82(3):269-74. doi: 10.1111/sji.12317.

Hüffmeier U, Uebe S, Ekici AB, Bowes J, Giardina E, Korendowych E, Juneblad K, Apel M, McManus R, Ho P, Bruce IN, Ryan AW, Behrens F, Lascorz J, Böhm B, Traupe H, Lohmann J, Gieger C, Wichmann HE, Herold C, Steffens M, Klareskog L, Wienker TF, Fitzgerald O, Alenius GM, McHugh NJ, Novelli G, Burkhardt H, Barton A, Reis A.Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat Genet. 2010 Nov;42(11):996-9. doi: 10.1038/ng.688. Epub 2010 Oct 17.