Ausgewählte Publikationen Molekularbiologie


Im Folgenden finden Sie ausgewählte Publikationen ab 2014. So bekommen Sie einen Einblick in unsere veröffentlichten Forschungsergebnisse im Bereich der Molekularbiologie.

Bereich Molekularbiologie

Vollständige Publikationslisten nach Jahren können Sie in unseren Jahresberichten ab 2009 einsehen (ab 2015 in den Annex Facts).

Wenn Sie gezielt nach Veröffentlichungen suchen möchten, nutzen Sie »Fraunhofer-Publica«, die Publikationsdatenbank der Fraunhofer-Gesellschaft.

Juli 2016 aktualisiert

Addai-Mensah, O., Seidel, M., Amidu, N., Maskus, D.J., Kapelski, S., Breuer, G., Franken, C., Owusu-Dabo, E., Frempong, M., Rakotozandrindrainy, R., Schinkel, H., Reimann, A., Klockenbring, T., Barth, S., Fischer, R., Fendel, R., 2016. Acquired immune responses to three malaria vaccine candidates and their relationship to invasion inhibition in two populations naturally exposed to malaria. Malar. J. 15, 65.

Amoury, M., Kolberg, K., Pham, A.-T., Hristodorov, D., Mladenov, R., Di Fiore, S., Helfrich, W., Kiessling, F., Fischer, R., Pardo, A., Thepen, T., Hussain, A.F., Nachreiner, T., Barth, S., 2016a. Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model. Cancer Lett. 372, 201–209.

Amoury, M., Mladenov, R., Nachreiner, T., Pham, A.-T., Hristodorov, D., Di Fiore, S., Helfrich, W., Pardo, A., Fey, G., Schwenkert, M., Thepen, T., Kiessling, F., Hussain, A.F., Fischer, R., Kolberg, K., Barth, S., 2016b. A novel approach for targeted elimination of CSPG4-positive triple-negative breast cancer cells using a MAP tau-based fusion protein. Int. J. Cancer 139, 916–927.

Arfi, Z.A., Hellwig, S., Drossard, J., Fischer, R., Buyel, J.F., 2016. Polyclonal antibodies for specific detection of tobacco host cell proteins can be efficiently generated following RuBisCO depletion and the removal of endotoxins. Biotechnology Journal 11, 507–518.

Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, J., Bernal-Delgado, E., Blomberg, N., Bock, C., Conesa, A., Del Signore, S., Delogne, C., Devilee, P., Di Meglio, A., Eijkemans, M., Flicek, P., Graf, N., Grimm, V., Guchelaar, H.-J., Guo, Y.-K., Gut, I.G., Hanbury, A., Hanif, S., Hilgers, R.-D., Honrado, Á., Hose, D.R., Houwing-Duistermaat, J., Hubbard, T., Janacek, S.H., Karanikas, H., Kievits, T., Kohler, M., Kremer, A., Lanfear, J., Lengauer, T., Maes, E., Meert, T., Müller, W., Nickel, D., Oledzki, P., Pedersen, B., Petkovic, M., Pliakos, K., Rattray, M., i Màs, J.R., Schneider, R., Sengstag, T., Serra-Picamal, X., Spek, W., Vaas, L.A.I., van Batenburg, O., Vandelaer, M., Varnai, P., Villoslada, P., Vizcaíno, J.A., Wubbe, J.P.M., Zanetti, G., 2016. Making sense of big data in health research: Towards an EU action plan. Genome Medicine 8, 71.

Barthelmes, J., Tafferner, N., Kurz, J., de Bruin, N., Parnham, M.J., Geisslinger, G., Schiffmann, S., 2016. Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues. J Vis Exp.

Beyer, S., Xie, L., Schmidt, M., de Bruin, N., Ashtikar, M., Rüschenbaum, S., Lange, C.M., Vogel, V., Mäntele, W., Parnham, M.J., Wacker, M.G., 2016. Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques. J Control Release 235, 352–364.

Bialon, M., Grezella, C., Friesen, L., Sieben, T., Pham, A.-T., Fischer, R., Barth, S., Püttmann, C., Stein, C., 2016. A Monoclonal Antibody That Discriminates Between SNAP-Tagged and CLIP-Tagged Proteins. Monoclon Antib Immunodiagn Immunother 35, 141–147.

Bodewein, L., Schmelter, F., Di Fiore, S., Hollert, H., Fischer, R., Fenske, M., 2016. Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines. Toxicol. Appl. Pharmacol. 305, 83–92.

Boes, A., Spiegel, H., Kastilan, R., Bethke, S., Voepel, N., Chudobová, I., Bolscher, J.M., Dechering, K.J., Fendel, R., Buyel, J.F., Reimann, A., Schillberg, S., Fischer, R., 2016. Analysis of the dose-dependent stage-specific in vitro efficacy of a multi-stage malaria vaccine candidate cocktail. Malar J 15.

Borsari, C., Luciani, R., Pozzi, C., Pöhner, I., Henrich, S., Trande, M., Cordeiro-da-Silva, A., Santarém, N., Baptista, C., Tait, A., Di Pisa, F., Dello Iacono, L., Landi, G., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Gribbon, P., Kohler, M., Keminer, O., Behrens, B., Costantino, L., Tejera Nevado, P., Bifeld, E., Eick, J., Clos, J., Torrado, J., Jiménez-Antón, M.D., Corral, M.J., Alunda, J.M., Pellati, F., Wade, R.C., Ferrari, S., Mangani, S., Costi, M.P., 2016. Profiling of flavonol derivatives for the development of anti-trypanosomatidic drugs. J. Med. Chem.

Brändl, B., Schuldt, B.M., Böhnke, L., Keminer, O., Vaas, L.A.I., Fischer, R., Müller, F.-J., Pless, O., 2016. Utilizing Regulatory Networks for Pluripotency Assessment in Stem Cells. Curr Stem Cell Rep 1–8.

Brenke, J.K., Salmina, E.S., Ringelstetter, L., Dornauer, S., Kuzikov, M., Rothenaigner, I., Schorpp, K., Giehler, F., Gopalakrishnan, J., Kieser, A., Gul, S., Tetko, I.V., Hadian, K., 2016. Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase–Glutathione Interaction. J Biomol Screen 21, 596–607.

Brenneis, M., Aghajaanpour, R., Knape, T., Sha, L.K., Neb, H., Meybohm, P., Zacharowski, K., Hauser, I.A., Büttner, S., Parnham, M.J., Brüne, B., von Knethen, A., 2016. Pparγ Expression in T Cells as a Prognostic Marker of Sepsis. Shock 45, 591–597.

Buyel, J., Twyman, R.M., Fischer, R., 2016. Very-large-scale Production of Monoclonal Antibodies in Plants, in: Gottschalk, U. (Ed.), Process Scale Purification of Antibodies. Wiley-Interscience.

Buyel, J.F., 2016. Numeric simulation can be used to predict heat transfer during the blanching of leaves and intact plants. Biochemical Engineering Journal 109, 118–126.

Buyel, J.F., 2016. Procedure to Evaluate the Efficiency of Flocculants for the Removal of Dispersed Particles from Plant Extracts. J Vis Exp.

Buyel, J.F., Hubbuch, J., Fischer, R., 2016. Comparison of Tobacco Host Cell Protein Removal Methods by Blanching Intact Plants or by Heat Treatment of Extracts. J Vis Exp.

Buyel, J.F., Gruchow, H.M., Tödter, N., Wehner, M., 2016. Determination of the thermal properties of leaves by non-invasive contact‑free laser probing. J. Biotechnol. 217, 100–108.

de Bruin, N.M.W.J., Schmitz, K., Schiffmann, S., Tafferner, N., Schmidt, M., Jordan, H., Häußler, A., Tegeder, I., Geisslinger, G., Parnham, M.J., 2016. Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behav. Brain Res. 300, 160–174.

Drebes, J., Künz, M., Windshügel, B., Kikhney, A.G., Müller, I.B., Eberle, R.J., Oberthür, D., Cang, H., Svergun, D.I., Perbandt, M., Betzel, C., Wrenger, C., 2016. Structure of ThiM from Vitamin B1 biosynthetic pathway of Staphylococcus aureus – Insights into a novel pro-drug approach addressing MRSA infections. Scientific Reports 6, 22871.

Ellinger, B., Gribbon, P., 2016. Risk mitigation in academic drug discovery. Expert Opinion on Drug Discovery 11, 333–336.

Frenz, T., Grabski, E., Buschjäger, D., Vaas, L.A.I., Burgdorf, N., Schmidt, R.E., Witte, T., Kalinke, U., 2016. CD4+ T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. Journal of Allergy and Clinical Immunology.

Fritsch, L., Soeur, R., Hansen, C., Fischer, R., Schillberg, S., Schröper, F., 2016. Next-generation sequencing of amplicons is a rapid and reliable method for the detection of polymorphisms relevant for barley breeding. Mol Breeding 36, 1–9.

Hanke, T., Merk, D., Steinhilber, D., Geisslinger, G., Schubert-Zsilavecz, M., 2016. Small molecules with anti-inflammatory properties in clinical development. Pharmacol. Ther. 157, 163–187.

Hauser, A.S., Windshügel, B., 2016. LEADS-PEP: A Benchmark Data Set for Assessment of Peptide Docking Performance. J. Chem. Inf. Model. 56, 188–200.

Hristodorov, D., Mladenov, R., Fischer, R., Barth, S., Thepen, T., 2016. Fully human MAP-fusion protein selectively targets and eliminates proliferating CD64(+) M1 macrophages. Immunol. Cell Biol. 94, 470–478.

King-Himmelreich, T.S., Schramm, S., Wolters, M.C., Schmetzer, J., Möser, C.V., Knothe, C., Resch, E., Peil, J., Geisslinger, G., Niederberger, E., 2016. The impact of endurance exercise on global and AMPK gene-specific DNA methylation. Biochem. Biophys. Res. Commun. 474, 284–290.

Klingler, F.-M., Wolf, M., Wittmann, S., Gribbon, P., Proschak, E., 2016. Bacterial Expression and HTS Assessment of Soluble Epoxide Hydrolase Phosphatase. J Biomol Screen 1087057116637609.

Klose, D., Saunders, U., Barth, S., Fischer, R., Jacobi, A.M., Nachreiner, T., 2016. Novel fusion proteins for the antigen-specific staining and elimination of B cell receptor-positive cell populations demonstrated by a tetanus toxoid fragment C (TTC) model antigen. BMC Biotechnol. 16, 18.

Knothe, C., Shiratori, H., Resch, E., Ultsch, A., Geisslinger, G., Doehring, A., Lötsch, J., 2016. Disagreement between two common biomarkers of global DNA methylation. Clin Epigenetics 8, 60.

Kringel, D., Ultsch, A., Zimmermann, M., Jansen, J.-P., Ilias, W., Freynhagen, R., Griessinger, N., Kopf, A., Stein, C., Doehring, A., Resch, E., Lötsch, J., 2016. Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses. Pharmacogenomics J.

Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G., Schachner, M., 2016. Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions. J. Neurochem. 136, 48–62.

Maculins, T., Carter, N., Dorval, T., Hudson, K., Nissink, J.W.M., Hay, R.T., Alwan, H., 2016a. A Generic Platform for Cellular Screening Against Ubiquitin Ligases. Sci Rep 6, 18940.

Maculins, T., Fiskin, E., Bhogaraju, S., Dikic, I., 2016b. Bacteria-host relationship: ubiquitin ligases as weapons of invasion. Cell Res. 26, 499–510.

Mandal, M.K., Ahvari, H., Schillberg, S., Schiermeyer, A., 2016. Tackling Unwanted Proteolysis in Plant Production Hosts Used for Molecular Farming. Front. Plant Sci. 267.

Menzel, S., Holland, T., Boes, A., Spiegel, H., Bolzenius, J., Fischer, R., Buyel, J.F., 2016. Optimized Blanching Reduces the Host Cell Protein Content and Substantially Enhances the Recovery and Stability of Two Plant-Derived Malaria Vaccine Candidates. Front Plant Sci 7, 159.

Mora, J., Schlemmer, A., Wittig, I., Richter, F., Putyrski, M., Frank, A.-C., Han, Y., Jung, M., Ernst, A., Weigert, A., Brüne, B., 2016. Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol.

Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Schäfers, C., Teigeler, M., Fenske, M., 2016. Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test. Aquat. Toxicol. 176, 116–127.

Niesen, J., Hehmann-Titt, G., Woitok, M., Fendel, R., Barth, S., Fischer, R., Stein, C., 2016a. A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor. Cancer Lett. 374, 229–240.

Niesen, J., Sack, M., Seidel, M., Fendel, R., Barth, S., Fischer, R., Stein, C., 2016b. SNAP-tag technology: a useful tool to determine affinity constants and other functional parameters of novel antibody fragments. Bioconjug. Chem.

Rasche, S., Herwartz, D., Schuster, F., Jablonka, N., Weber, A., Fischer, R., Schillberg, S., 2016. More for less: Improving the biomass yield of a pear cell suspension culture by design of experiments. Sci Rep 6.

Rees, S., Gribbon, P., Birmingham, K., Janzen, W.P., Pairaudeau, G., 2016. Towards a hit for every target. Nat Rev Drug Discov 15, 1–2.

Roos, J., Grösch, S., Werz, O., Schröder, P., Ziegler, S., Fulda, S., Paulus, P., Urbschat, A., Kühn, B., Maucher, I., Fettel, J., Vorup-Jensen, T., Piesche, M., Matrone, C., Steinhilber, D., Parnham, M.J., Maier, T.J., 2016. Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? Pharmacol. Ther. 157, 43–64.

Schinkel, H., Schillberg, S., 2016. Genome editing: intellectual property and product development in plant biotechnology. Plant Cell Rep. 35, 1487–1491.

Schneider, K., Schiermeyer, A., Dolls, A., Koch, N., Herwartz, D., Kirchhoff, J., Fischer, R., Russell, S.M., Cao, Z., Corbin, D.R., Sastry-Dent, L., Ainley, W.M., Webb, S.R., Schinkel, H., Schillberg, S., 2016. Targeted gene exchange in plant cells mediated by a zinc finger nuclease double cut. Plant Biotechnol. J. 14, 1151–1160.

Schröder, M., Kolodzik, A., Windshügel, B., Krepstakies, M., Priyadarshini, P., Hartjen, P., van Lunzen, J., Rarey, M., Hauber, J., Meier, C., 2016. Linker-Region Modified Derivatives of the Deoxyhypusine Synthase Inhibitor CNI-1493 Suppress HIV-1 Replication. Arch. Pharm. Chem. Life Sci. 349, 91–103.

Sisignano, M., Parnham, M.J., Geisslinger, G., 2016. Drug Repurposing for the Development of Novel Analgesics. Trends Pharmacol. Sci. 37, 172–183.

Tafferner, N., Barthelmes, J., Eberle, M., Ulshöfer, T., Henke, M., deBruin, N., Mayer, C.A., Foerch, C., Geisslinger, G., Parnham, M.J., Schiffmann, S., 2016. Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. Eur. J. Immunol. 46, 570–581.

Thom, V., Schmid, S., Gelderblom, M., Hackbusch, R., Kolster, M., Schuster, S., Thomalla, G., Keminer, O., Pleß, O., Bernreuther, C., Glatzel, M., Wegscheider, K., Gerloff, C., Magnus, T., Tolosa, E., 2016. IL-17 production by CSF lymphocytes as a biomarker for cerebral vasculitis. Neurol Neuroimmunol Neuroinflamm 3, e214.

Vasilev, N., Smales, C.M., Schillberg, S., Fischer, R., Schiermeyer, A., 2016. Developments in the production of mucosal antibodies in plants. Biotechnol. Adv. 34, 77–87.

von Felbert, V., Bauerschlag, D., Maass, N., Bräutigam, K., Meinhold-Heerlein, I., Woitok, M., Barth, S., Hussain, A.F., 2016. A specific photoimmunotheranostics agent to detect and eliminate skin cancer cells expressing EGFR. J. Cancer Res. Clin. Oncol. 142, 1003–1011.

Wegner, M.-S., Schiffmann, S., Parnham, M.J., Geisslinger, G., Grösch, S., 2016. The enigma of ceramide synthase regulation in mammalian cells. Prog. Lipid Res. 63, 93–119.


Behrens, F., Tak, P.P., Østergaard, M., Stoilov, R., Wiland, P., Huizinga, T.W., Berenfus, V.Y., Vladeva, S., Rech, J., Rubbert-Roth, A., Korkosz, M., Rekalov, D., Zupanets, I.A., Ejbjerg, B.J., Geiseler, J., Fresenius, J., Korolkiewicz, R.P., Schottelius, A.J., Burkhardt, H., 2015. MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial. Ann. Rheum. Dis. 74, 1058–1064.

Beiss, V., Spiegel, H., Boes, A., Kapelski, S., Scheuermayer, M., Edgue, G., Sack, M., Fendel, R., Reimann, A., Schillberg, S., Pradel, G., Fischer, R., 2015a. Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein. Biotechnol. Bioeng. 112, 1297–1305.

Beiss, V., Spiegel, H., Boes, A., Scheuermayer, M., Reimann, A., Schillberg, S., Fischer, R., 2015b. Plant expression and characterization of the transmission-blocking vaccine candidate PfGAP50. BMC Biotechnology 15, 108.

Beyer, S., Moosmann, A., Kahnt, A.S., Ulshöfer, T., Parnham, M.J., Ferreirós, N., Wagner, S., Wacker, M.G., 2015. Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox. Pharm. Res. 32, 3986–3998.

Boes, A., Spiegel, H., Edgue, G., Kapelski, S., Scheuermayer, M., Fendel, R., Remarque, E., Altmann, F., Maresch, D., Reimann, A., Pradel, G., Schillberg, S., Fischer, R., 2015a. Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits. Plant Biotechnol J 13, 222–234.

Boes, A., Spiegel, H., Voepel, N., Edgue, G., Beiss, V., Kapelski, S., Fendel, R., Scheuermayer, M., Pradel, G., Bolscher, J.M., Behet, M.C., Dechering, K.J., Hermsen, C.C., Sauerwein, R.W., Schillberg, S., Reimann, A., Fischer, R., 2015b. Analysis of a Multi-component Multi-stage Malaria Vaccine Candidate--Tackling the Cocktail Challenge. PLoS ONE 10, e0131456.

Bortesi, L., Fischer, R., 2015. The CRISPR/Cas9 system for plant genome editing and beyond. Biotechnology Advances 33, 41–52.

Brändl, B., Schneider, S.A., Loring, J.F., Hardy, J., Gribbon, P., Müller, F.-J., 2015. Stem cell reprogramming: basic implications and future perspective for movement disorders. Mov. Disord. 30, 301–312.

Brehm, H., Hristodorov, D., Pardo, A., Mladenov, R., Niesen, J., Fischer, R., Tur, M.K., Barth, S., 2015. Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein. Cancer Lett. 365, 149–155.

Buntru, M., Vogel, S., Stoff, K., Spiegel, H., Schillberg, S., 2015. A versatile coupled cell-free transcription–translation system based on tobacco BY-2 cell lysates. Biotechnol. Bioeng. 112, 867–878.

Buyel, J.F., 2015. Controlling the interplay between Agrobacterium tumefaciens and plants during the transient expression of proteins. Bioengineered 6, 242–244.

Buyel, J.F., 2015. Process Development Strategies in Plant Molecular Farming. Curr Pharm Biotechnol 16, 966–982.

Buyel, J.F., Buyel, J.J., Haase, C., Fischer, R., 2015a. The impact of Pseudomonas syringae type III effectors on transient protein expression in tobacco. Plant Biol (Stuttg) 17, 484–492.

Buyel, J.F., Gruchow, H.M., Fischer, R., 2015. Depth Filters Containing Diatomite Achieve More Efficient Particle Retention than Filters Solely Containing Cellulose Fibers. Front Plant Sci 6, 1134.

Buyel, J.F., Twyman, R.M., Fischer, R., 2015b. Extraction and downstream processing of plant-derived recombinant proteins. Biotechnol. Adv. 33, 902–913.

Cheng, X., Dimou, E., Alborzinia, H., Wenke, F., Göhring, A., Reuter, S., Mah, N., Fuchs, H., Andrade-Navarro, M.A., Adjaye, J., Gul, S., Harms, C., Utikal, J., Klipp, E., Mrowka, R., Wölfl, S., 2015a. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and Derivatives as Potent Oct3/4 Inducers. J. Med. Chem. 58, 4976–4983.

Cheng, X., Yoshida, H., Raoofi, D., Saleh, S., Alborzinia, H., Wenke, F., Göhring, A., Reuter, S., Mah, N., Fuchs, H., Andrade-Navarro, M.A., Adjaye, J., Gul, S., Utikal, J., Mrowka, R., Wölfl, S., 2015b. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J. Med. Chem. 58, 5742–5750.

Cremer, C., Vierbuchen, T., Hein, L., Fischer, R., Barth, S., Nachreiner, T., 2015. Angiogenin mutants as novel effector molecules for the generation of fusion proteins with increased cytotoxic potential. J. Immunother. 38, 85–95.

Epping, J., van Deenen, N., Niephaus, E., Stolze, A., Fricke, J., Huber, C., Eisenreich, W., Twyman, R.M., Prüfer, D., Schulze Gronover, C., 2015. A rubber transferase activator is necessary for natural rubber biosynthesis in dandelion. Nature Plants 1, 15048.

Faber, B.W., Hellwig, S., Houard, S., Havelange, N., Drossard, J., Mertens, H., Croon ,A., Byrne, R., van der Werff, N., van der Eijk, M., Thomas, A.W., Kocken, C.H.M. and Remarque, E.J.: Production, quality control, stability and pharmacotoxicity of a mixture of three cGMP-produced Diversity Covering Plasmodium falciparum AMA1 proteins, submitted

Fritsch, L., Fischer, R., Wambach, C., Dudek, M., Schillberg, S., Schröper, F., 2015. Next-generation sequencing is a robust strategy for the high-throughput detection of zygosity in transgenic maize. Transgenic Res. 24, 615–623.

Hristodorov, D., Mladenov, R., von Felbert, V., Huhn, M., Fischer, R., Barth, S., Thepen, T., 2015. Targeting CD64 mediates elimination of M1 but not M2 macrophages in vitro and in cutaneous inflammation in mice and patient biopsies. MAbs 7, 853–862.

Jennewein, C., Sowa, R., Faber, A.C., Dildey, M., von Knethen, A., Meybohm, P., Scheller, B., Dröse, S., Zacharowski, K., 2015. Contribution of Ninjurin1 to Toll-like receptor 4 signaling and systemic inflammation. Am. J. Respir. Cell Mol. Biol. 53, 656–663.

Kapelski, S., Boes, A., Spiegel, H., de Almeida, M., Klockenbring, T., Reimann, A., Fischer, R., Barth, S., Fendel, R., 2015a. Fast track antibody V-gene rescue, recombinant expression in plants and characterization of a PfMSP4-specific antibody. Malar. J. 14, 50.

Kapelski, S., de Almeida, M., Fischer, R., Barth, S., Fendel, R., 2015b. Antimalarial activity of granzyme B and its targeted delivery by a granzyme B-single-chain Fv fusion protein. Antimicrob. Agents Chemother. 59, 669–672.

Laibach, N., Hillebrand, A., Twyman, R.M., Prüfer, D., Schulze Gronover, C., 2015. Identification of a Taraxacum brevicorniculatum rubber elongation factor protein that is localized on rubber particles and promotes rubber biosynthesis. Plant J. 82, 609–620.

Lötsch, J., Knothe, C., Lippmann, C., Ultsch, A., Hummel, T., Walter, C., 2015. Olfactory drug effects approached from human-derived data. Drug Discov. Today 20, 1398–1406.

Lu, R., Bausch, A.E., Kallenborn-Gerhardt, W., Stoetzer, C., Debruin, N., Ruth, P., Geisslinger, G., Leffler, A., Lukowski, R., Schmidtko, A., 2015. Slack channels expressed in sensory neurons control neuropathic pain in mice. J. Neurosci. 35, 1125–1135.

Ma, J.K.-C., Drossard, J., Lewis, D., Altmann, F., Boyle, J., Christou, P., Cole, T., Dale, P., van Dolleweerd, C.J., Isitt, V., Katinger, D., Lobedan, M., Mertens, H., Paul, M.J., Rademacher, T., Sack, M., Hundleby, P.A.C., Stiegler, G., Stoger, E., Twyman, R.M., Vcelar, B., Fischer, R., 2015. Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants. Plant Biotechnol. J. 13, 1106–1120.

Maskus, D.J., Bethke, S., Seidel, M., Kapelski, S., Addai-Mensah, O., Boes, A., Edgü, G., Spiegel, H., Reimann, A., Fischer, R., Barth, S., Klockenbring, T., Fendel, R., 2015. Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10. Malar. J. 14, 276.

Mladenov, R., Hristodorov, D., Cremer, C., Hein, L., Kreutzer, F., Stroisch, T., Niesen, J., Brehm, H., Blume, T., Brümmendorf, T.H., Jost, E., Thepen, T., Fischer, R., Stockmeyer, B., Barth, S., Stein, C., 2015. The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia. Int. J. Cancer 137, 2729–2738.

Namgaladze, D., Snodgrass, R.G., Angioni, C., Grossmann, N., Dehne, N., Geisslinger, G., Brüne, B., 2015. AMP-activated protein kinase suppresses arachidonate 15-lipoxygenase expression in interleukin 4-polarized human macrophages. J. Biol. Chem. 290, 24484–24494.

Niesen, J., Brehm, H., Stein, C., Berges, N., Pardo, A., Fischer, R., Ten Haaf, A., Gattenlöhner, S., Tur, M.K., Barth, S., 2015a. In vitro effects and ex vivo binding of an EGFR-specific immunotoxin on rhabdomyosarcoma cells. J. Cancer Res. Clin. Oncol. 141, 1049–1061.

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