Veröffentlichungen Translationale Medizin

Stand 30.06.2018

Ashtikar, M., Wacker, M.G. Nanopharmaceuticals for wound healing – Lost in translation? (2018) Advanced Drug Delivery Reviews, 129, 194-218.

Burk, O., Kuzikov, M., Kronenberger, T., Jeske, J., Keminer, O., Thasler, W.E., Schwab, M., Wrenger, C., Windshügel, B. Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles (2018) Archives of Toxicology, 92 (4), 1435-1451.

de Bruin, N., Ferreirós, N., Schmidt, M., Hofmann, M., Angioni, C., Geisslinger, G., Parnham, M.J. Mutual inversion of flurbiprofen enantiomers in various rat and mouse strains (2018) Chirality, 30 (5), 632-641.

Eresch, J., Stumpf, M., Koch, A., Vutukuri, R., Ferreirós, N., Schreiber, Y., Schröder, K., Devraj, K., Popp, R., Hattenbach, L.-O., Pfeilschifter, J., Pfeilschifter, W.Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy(2018) Investigative Ophthalmology and Visual Science, 59 (2), 653-661.

Gossec, L., McGonagle, D., Korotaeva, T., Lubrano, E., De Miguel, E., Østergaard, M., Behrens, F. Minimal disease activity as a treatment target in psoriatic arthritis: A review of the literature (2018) Journal of Rheumatology, 45 (1), 6-13.

Hitzel, J., Lee, E., Zhang, Y., Bibli, S.I., Li, X., Zukunft, S., Pflüger, B., Hu, J., Schürmann, C., Vasconez, A.E., Oo, J.A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C.E., Kroll, J., Jo, H., Landmesser, U., Lusis, A.J., Namgaladze, D., Fleming, I., Leisegang, M.S., Zhu, J., Brandes, R.P. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells (2018) Nature Communications, 9 (1), art. no. 2292.

Hofmann, M.C.J., Schmidt, M., Arne, O., Geisslinger, G., Parnham, M.J., de Bruin, N.M.W.J. Non-invasive bioluminescence imaging as a standardized assessment measure in mouse models of dermal inflammation (2018) Journal of Dermatological Science, Article in Press.

Jung, F., Nothnagel, L., Gao, F., Thurn, M., Vogel, V., Wacker, M.G. A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling (2018) European Journal of Pharmaceutics and Biopharmaceutics, 127, 462-470.

Kirchner, J., Brüne, B., Namgaladze, D. AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages (2018) Scientific Reports, 8 (1), art. no. 7801,

Kramer, J., Désor, V., Brunst, S., Wittmann, S.K., Lausen, J., Heering, J., Proschak, A., Proschak, E. A coupled fluorescence-based assay for the detection of protein arginine N-methyltransferase 6 (PRMT6) enzymatic activity (2018) Analytical Biochemistry, 547, 7-13.

Kronenberger, T., Windshügel, B., Wrenger, C., Honorio, K.M., Maltarollo, V.G. On the relationship of anthranilic derivatives structure and the FXR (Farnesoid X receptor) agonist activity (2018) Journal of Biomolecular Structure and Dynamics, 1-14. Article in Press.

Lippmann, C., Kringel, D., Ultsch, A., Lötsch, J. Computational functional genomics-based approaches in analgesic drug discovery and repurposing (2018) Pharmacogenomics, 19 (9), 783-797.

Lötsch, J., Geisslinger, G., Heinemann, S., Lerch, F., Oertel, B.G., Ultsch, A. Quantitative sensory testing response patterns to capsaicin- and ultraviolet-B-induced local skin hypersensitization in healthy subjects: A machine-learned analysis (2018) Pain, 159 (1), 11-24.

Lötsch, J., Kringel, D. Use of Computational Functional Genomics in Drug Discovery and Repurposing for Analgesic Indications (2018) Clinical Pharmacology and Therapeutics, . Article in Press.

Lötsch, J., Sipilä, R., Tasmuth, T., Kringel, D., Estlander, A.-M., Meretoja, T., Kalso, E., Ultsch, A. Machine-learning-derived classifier predicts absence of persistent pain after breast cancer surgery with high accuracy (2018) Breast Cancer Research and Treatment, 1-13. Article in Press.

Lötsch, J., Weyer-Menkhoff, I., Tegeder, I. Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings (2018) European Journal of Pain (United Kingdom), 22 (3), 471-484.

Nothnagel, L., Wacker, M.G. How to measure release from nanosized carriers? (2018) European Journal of Pharmaceutical Sciences, 120, 199-211.

Patas, K., Willing, A., Demiralay, C., Engler, J.B., Lupu, A., Ramien, C., Schäfer, T., Gach, C., Stumm, L., Chan, K., Vignali, M., Arck, P.C., Friese, M.A., Pless, O., Wiedemann, K., Agorastos, A., Gold, S.M. T cell phenotype and T cell receptor repertoire in patients with major depressive disorder (2018) Frontiers in Immunology, 9 (FEB), art. no. 291,

Proft, F., Schulze-Koops, H., Grunke, M., Schrezenmeier, E., Halleck, F., Henes, J., Unger, L., Schmidt, E., Fiehn, C., Jacobi, A., Iking-Konert, C., Kneitz, C., Schmidt, R.E., Bannert, B., Voll, R.E., Fischer-Betz, R., Kötter, I., Tony, H.P., Holle, J., Aringer, M., Erler, A., Behrens, F., Burmester, G.R., Dörner, T. Safety and efficacy of off-label use of biologic therapies in patients with inflammatory rheumatic diseases refractory to standard of care therapy: Data from a nationwide German registry (GRAID2) [Sicherheit und Wirksamkeitshinweise zum Off-label-Einsatz von Biologikatherapien nach Versagen konventioneller Therapien bei Patienten mit entzündlich rheumatischen Erkrankungen: Ergebnisse eines nationalen Registers (GRAID2)] (2018) Zeitschrift fur Rheumatologie, 77 (1), 28-39.

Roos, J., Peters, M., Maucher, I.V., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Sommer, B., Urbschat, A., Piesche, M., Vogel, A., Proschak, E., Blöcher, R., Buscató, E., Häfner, A.-K., Matrone, C., Werz, O., Heidler, J., Wittig, I., Angioni, C., Geisslinger, G., Parnham, M.J., Zacharowski, K., Steinhilber, D., Maier, T.J. Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy (2018) Antioxidants and Redox Signaling, 28 (14), 1265-1285.

Sehnert, B., Burkhardt, H., Finzel, S., Dübel, S., Voll, R.E. The sneaking ligand approach for cell type-specific modulation of intracellular signalling pathways (2018) Clinical Immunology, 186,  14-20.

Sekar, D., Govene, L., Del Río, M.-L., Sirait-Fischer, E., Fink, A.F., Brüne, B., Rodriguez-Barbosa, J.I., Weigert, A. Downregulation of BTLA on NKT cells promotes tumor immune control in a mouse model of mammary Carcinoma (2018) International Journal of Molecular Sciences, 19 (3), art. no. 752,

Shiratori, H., Feinweber, C., Luckhardt, S., Wallner, N., Geisslinger, G., Weigert, A., Parnham, M.J. An in vitro test system for compounds that modulate human inflammatory macrophage polarization (2018) European Journal of Pharmacology, 833, 328-338.

Spry, C., Sewell, A.L., Hering, Y., Villa, M.V.J., Weber, J., Hobson, S.J., Harnor, S.J., Gul, S., Marquez, R., Saliba, K.J. Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation

Stürner, K.H., Stellmann, J.-P., Dörr, J., Paul, F., Friede, T., Schammler, S., Reinhardt, S., Gellissen, S., Weissflog, G., Faizy, T.D., Werz, O., Fleischer, S., Vaas, L.A.I., Herrmann, F., Pless, O., Martin, R., Heesen, C. A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial) (2018) Journal of Neurology, Neurosurgery and Psychiatry, 89 (4), 330-338.

Toewe, A., Balas, L., Durand, T., Geisslinger, G., Ferreirós, N. Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry (2018) Analytica Chimica Acta, . Article in Press.

Vögtle, F.-N., Brändl, B., Larson, A., Pendziwiat, M., Friederich, M.W., White, S.M., Basinger, A., Kücükköse, C., Muhle, H., Jähn, J.A., Keminer, O., Helbig, K.L., Delto, C.F., Myketin, L., Mossmann, D., Burger, N., Miyake, N., Burnett, A., van Baalen, A., Lovell, M.A., Matsumoto, N., Walsh, M., Yu, H.-C., Shinde, D.N., Stephani, U., Van Hove, J.L.K., Müller, F.-J., Helbig, I. Mutations in PMPCB Encoding the Catalytic Subunit of the Mitochondrial Presequence Protease Cause Neurodegeneration in Early Childhood (2018) American Journal of Human Genetics, 102 (4), 557-573.

Wegner, M.-S., Schömel, N., Gruber, L., Örtel, S.B., Kjellberg, M.A., Mattjus, P., Kurz, J., Trautmann, S., Peng, B., Wegner, M., Kaulich, M., Ahrends, R., Geisslinger, G., Grösch, S. UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells (2018) Cellular and Molecular Life Sciences, 1-18. Article in Press.

Weigert, A., von Knethen, A., Fuhrmann, D., Dehne, N., Brüne, B. Redox-signals and macrophage biology (for the upcoming issue of molecular aspects of medicine on signaling by reactive oxygen species) (2018) Molecular Aspects of Medicine,

Weyer-Menkhoff, I., Thrun, M.C., Lötsch, J. Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects (2018) European Journal of Pain (United Kingdom), 22 (5), 862-874.

Zimmer, B., Angioni, C., Osthues, T., Toewe, A., Thomas, D., Pierre, S.C., Geisslinger, G., Scholich, K., Sisignano, M. The oxidized linoleic acid metabolite 12,13-DiHOME mediates thermal hyperalgesia during inflammatory pain (2018) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863 (7), 669-678.

Behrens, F., Thaci, D., Wollenhaupt, J., Kruger, K., 2017 Psoriatic arthritis : Overview of drug therapy options and administration characteristics. Hautarzt No. 68(2): 153-169.

Bender, C., Christen, S., Scholich, K., Bayer, M., Pfeilschifter, J.M., Hintermann, E., Christen, U., 2017 Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes. Diabetes (2017) No. 66(1): 113-126.

Borsari, C., Santarem, N., Torrado, J., Olías, A.I., Corral, M.J., Baptista, C., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Witt, G., Gribbon, P., Reinshagen, J., Linciano, P., Tait, A., Costantino, L., Freitas-Junior, L.H., Moraes, C.B., Bruno dos Santos, P., Alcântara, L.M., Franco, C.H., Bertolacini, C.D., Fontana, V., Tejera Nevado, P., Clos, J., Alunda, J.M., Cordeiro-da-Silva, A., Ferrari, S., Costi, M.P., 2017. Methoxylated 2’-hydroxychalcones as antiparasitic hit compounds. European Journal of Medicinal Chemistry 126, 1129–1135.

Dehne, N., Mora, J., Namgaladze, D., Weigert, A., Brüne, B., 2017. Cancer cell and macrophage cross-talk in the tumor microenvironment. Current Opinion in Pharmacology 35, 12–19.

Di Pisa, F., Landi, G., Dello Iacono, L., Pozzi, C., Borsari, C., Ferrari, S., Santucci, M., Santarem, N., Cordeiro-Da-Silva, A., Moraes, C.B., Alcantara, L.M., Fontana, V., Freitas-Junior, L.H., Gul, S., Kuzikov, M., Behrens, B., Pöhner, I., Wade, R.C., Costi, M.P., Mangani, S., 2017. Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity. Molecules 22.

Dimova, V., Oertel, B.G., Lötsch, J., 2017. Using a standardized clinical quantitative sensory testing battery to judge the clinical relevance of sensory differences between adjacent body areas. Clinical Journal of Pain 33, 37–43.

Florian, P., Wonerow, P., Harder, S., Kuczka, K., Dubar, M., Graff, J., 2017. Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber. Eur J Clin Pharmacol 73, 949–956.

Fuhrmann, D.C., Brüne, B., 2017. Mitochondrial composition and function under the control of hypoxia. Redox Biology 12, 208–215.

Grösch, S., Niederberger, E., Geisslinger, G., 2017. Investigational drugs targeting the prostaglandin E2 signaling pathway for the treatment of inflammatory pain. Expert Opinion on Investigational Drugs 26, 51–61.

Hausen, J., Otte, J.C., Legradi, J., Yang, L., Strähle, U., Fenske, M., Hecker, M., Tang, S., Hammers-Wirtz, M., Hollert, H., Keiter, S.H., Ottermanns, R., 2017. Fishing for contaminants: identification of three mechanism specific transcriptome signatures using Danio rerio embryos. Environ Sci Pollut Res 1–14.

Hohmann, S.W., Angioni, C., Tunaru, S., Lee, S., Woolf, C.J., Offermanns, S., Geisslinger, G., Scholich, K., Sisignano, M., 2017. The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Scientific Reports 7.

Janas, C., Mast, M.-P., Kirsamer, L., Angioni, C., Gao, F., Mäntele, W., Dressman, J., Wacker, M.G., 2017. The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers. European Journal of Pharmaceutics and Biopharmaceutics 115, 73–83.

Jeske, J., Windshügel, B., Thasler, W.E., Schwab, M., Burk, O., 2017. Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor. Archives of Toxicology 91, 2375–2390.

Jung, M., Mertens, C., Bauer, R., Rehwald, C., Brüne, B., 2017a. Lipocalin-2 and iron trafficking in the tumor microenvironment. Pharmacological Research 120, 146–156.

Jung, M., Weigert, A., Mertens, C., Rehwald, C., Brüne, B., 2017b. Iron handling in tumor-associated macrophages-Is there a new role for lipocalin-2? Frontiers in Immunology 8.

Koch, A., Grammatikos, G., Trautmann, S., Schreiber, Y., Thomas, D., Bruns, F., Pfeilschifter, J., Badenhoop, K., Penna-Martinez, M., 2017. Vitamin D supplementation enhances C18(Dihydro)ceramide levels in type 2 diabetes patients. International Journal of Molecular Sciences 18.

Kringel, D., Sisignano, M., Zinn, S., Lötsch, J., 2017. Next-generation sequencing of the human TRPV1 gene and the regulating co-players LTB4R and LTB4R2 based on a custom AmpliSeqTM panel. PLoS ONE 12.

Niederberger, E., Resch, E., Parnham, M.J., Geisslinger, G., 2017. Drugging the pain epigenome. Nature Reviews Neurology 13, 434–447.

Oertel, S., Scholich, K., Weigert, A., Thomas, D., Schmetzer, J., Trautmann, S., Wegner, M.-S., Radeke, H.H., Filmann, N., Brüne, B., Geisslinger, G., Tegeder, I., Grösch, S., 2017. Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell. Mol. Life Sci. 74, 3039–3055.

Parnham, M.J., 2017. Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications. Inflammation Research 66.

Pierre, S., Linke, B., Suo, J., Tarighi, N., Del Turco, D., Thomas, D., Ferreiros, N., Stegner, D., Frölich, S., Sisignano, M., Meyer Dos Santos, S., deBruin, N., Nüsing, R.M., Deller, T., Nieswandt, B., Geisslinger, G., Scholich, K., 2017. GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation. Journal of Investigative Dermatology 137, 686–695.

Rahlff, J., Peters, J., Moyano, M., Pless, O., Claussen, C., Peck, M.A., 2017. Short-term molecular and physiological responses to heat stress in neritic copepods Acartia tonsa and Eurytemora affinis. Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology 203, 348–358.

Schneider, C., Oellerich, T., Baldauf, H.-M., Schwarz, S.-M., Thomas, D., Flick, R., Bohnenberger, H., Kaderali, L., Stegmann, L., Cremer, A., Martin, M., Lohmeyer, J., Michaelis, M., Hornung, V., Schliemann, C., Berdel, W.E., Hartmann, W., Wardelmann, E., Comoglio, F., Hansmann, M.-L., Yakunin, A.F., Geisslinger, G., Ströbel, P., Ferreirós, N., Serve, H., Keppler, O.T., Cinatl, J., 2017. SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia. Nature Medicine 23, 250–255.

Sonnack, L., Klawonn, T., Kriehuber, R., Hollert, H., Schäfers, C., Fenske, M., 2017. Concentration dependent transcriptome responses of zebrafish embryos after exposure to cadmium, cobalt and copper. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics 24, 29–40.

Stolz, A., Putyrski, M., Kutle, I., Huber, J., Wang, C., Major, V., Sidhu, S.S., Youle, R.J., Rogov, V.V., Dötsch, V., Ernst, A., Dikic, I., 2017. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. EMBO Journal 36, 549–564.

Ueck, C., Volksdorf, T., Houdek, P., Vidal-Y-Sy, S., Sehner, S., Ellinger, B., Lobmann, R., Larena-Avellaneda, A., Reinshagen, K., Ridderbusch, I., Kohrmeyer, K., Moll, I., Daniels, R., Werner, P., Merfort, I., Brandner, J.M., 2017. Comparison of in-vitro and ex-vivo wound healing assays for the investigation of diabetic wound healing and demonstration of a beneficial effect of a triterpene extract. PLoS ONE 12.

von Delius, M., Le, C.M., Ellinger, B., Kuzikov, M., Gul, S., Dong, V.M., 2017. Synthesis and Biological Activity of Octaketides from the Cytosporone Family. Israel Journal of Chemistry 57, 975–981.

Wobst, I., Ebert, L., Birod, K., Wegner, M.-S., Hoffmann, M., Thomas, D., Angioni, C., Parnham, M.J., Steinhilber, D., Tegeder, I., Geisslinger, G., Grösch, S., 2017. R-flurbiprofen traps prostaglandins within cells by inhibition of multidrug resistance-associated protein-4. International Journal of Molecular Sciences 18.

Zinn, S., Sisignano, M., Kern, K., Pierre, S., Tunaru, S., Jordan, H., Suo, J., Treutlein, E.-M., Angioni, C., Ferreiros, N., Leffler, A., Debruin, N., Offermanns, S., Geisslinger, G., Scholich, K., 2017. The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons. Journal of Biological Chemistry 292, 6123–6134.

A - C

Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, Bernal- Delgado E. et al.: Making sense of big data in health research: Towards an EU action plan. Genome Medicine (2016) No.8(1): 71 (

Aygören-Pürsün, E., Magerl, M., Graff, J., Martinez-Saguer, I., Kreuz, W., Longhurst, H., Nasr, I., Bas, M., Straßen, U., Fang, L., Cornpropst, M., Dobo, S., Collis, P., Sheridan, W.P., Maurer, M.: Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. The Journal of Allergy Clinical Immunology (2016) pii: S0091-6749(16)30270-6 (

Barthelmes, J., Tafferner, N., Kurz, J., de Bruin, N., Parnham, M.J., Geisslinger, G., Schiffmann, S.: Induction of experimental autoimmune encephalomyelitis in mice and evaluation of the disease-dependent distribution of immune cells in various tissues. Journal of visualized experiments: JoVE. Online resource 2016 (2016) No. 111 (

Behrens, F., Koehm, M., Thaci, D., Gnann, H., Greger, G., Wittig, B.M., Burkhardt, H.: Anti-citrullinated protein antibodies are linked to erosive disease in an observational study of patients with psoriatic arthritis. Rheumatology 55 (2016) No. 10: 1791- 1795 (

Behrens, F., Koehm, M., Arndt, U., Wittig, B.M., Greger, G., Thaci, D., Scharbatke, E., Tony, H.-P., Burkhardt, H.: Does concomitant methotrexate with Progadalimumab influence treatment outcomes in patients with psoriatic arthritis? Data from a large observational study. The Journal of Rheumatology 43 (2016) No. 3: 632-639 (

Behrens, F., Thaci, D., Wollenhaupt, J., Krüger, K.: Psoriasisarthritis: Übersicht medikamentöser Therapieoptionen und Anwendungsbesonderheiten. Zeitschrift für Rheumatologie 75 (2016) No. 5, 471-488 (

Beyer, S., Xie, L., Schmidt, M., de Bruin, N., Ashtikar, M., Rüschenbaum, S., Lange, C.M., Vogel, V.; Mäntele, W., Parnham, M.J., Wacker, M.G.: Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques. Journal of controlled release 235 (2016), 352-364 (

Blöcher, R., Lamers, C., Wittmann, S.K., Merk, D., Hartmann, M., Weizel, L., Diehl, O., Brüggerhoff, A., Boss, M., Kaiser, A., Schader, T., Gobel, T., Grundmann, M., Angioni, C., Heering, J., Geisslinger, G., Wurglics, M., Kostenis, E., Brüne, B., Steinhilber, D., Schubert-Zsilavecz, M., Kahnt, A.S., Proschak, E.: N-Benzylbenzamides: A novel merged scaffold for orally available dual soluble epoxide hydrolase/peroxisome proliferator-activated receptor gamma modulators. Journal of medicinal chemistry 59 (2016) No. 1: 61-81 (

Bodewein, L., Schmelter, F., Di Fiore, S., Hollert, H., Fischer, R., Fenske, M.: Differences in toxicity of anionic and cationic PAMAM and PPI dendrimers in zebrafish embryos and cancer cell lines. Toxicology and Applied Pharmacology 305 (2016) 83-92 (

Borsari, C., Luciani, R., Pozzi, C., Poehner, I., Henrich, S., Trande, M., Cordeiro-da- Silva, A., Santarem, N., Baptista, C., Tait, A., Di Pisa, F., Dello Iacono, L., Landi, G., Gul, S., Wolf, M., Kuzikov, M., Ellinger, B., Reinshagen, J., Witt, G., Gribbon, P., Kohler, M., Keminer, O., Behrens, B., Costantino, L., Tejera Nevado, P., Bifeld, E., Eick, J., Clos, J., Torrado, J., Jiménez- Antón, M.D., Corral, M.J., Alunda, J.M., Pellati, F., Wade, R.C., Ferrari, S., Mangani, S., Costi, M.P.: Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs. Journal of Medicinal Chemistry (2016) No. 59(16): 7598-7616 (

Boß, M., Newbatt, Y., Gupta, S., Collins, I., Brüne, B., Namgaladze, D.: AMPK-independent inhibition of human macrophage ER stress response by AICAR. Scientific Reports 6 (2016), Art. 32111, 10 (

Brändl, B., Schuldt, B.M., Böhnke, L., Keminer, O., Vaas, L.A.I., Fischer, R., Müller, F.J., Pless, O.: Utilizing regulatory networks for pluripotency assessment in stem cells. Current Stem Cell Reports (2016), No. 2(3): 228-235. Review. (

Brenke, J.K., Salmina, E.S., Ringelstetter, L., Dornauer, S., Kuzikov, M., Rothenaigner, I., Schorpp, K., Giehler, F., Gopalakrishnan, J., Kieser, A., Gul, S., Tetko, I.V., Hadian, K.: Identification of small-molecule frequent hitters of glutathione s-transferase- glutathione interaction. Journal of Biomolecular Screening 21 (2016) No.6: 596-607 (

Brenneis, M., Aghajaanpour, R., Knape, T., Sha, L.K., Neb, H., Meybohm, P., Zacharowski, K., Hauser, I.A., Buttner, S., Parnham, M.J., Brune, B., Von Knethen, A.: Pparg Expression in T Cells as a Prognostic Marker of Sepsis. Shock 45 (2016), No. 6: 591-597 (

Briken, S., Rosenkranz, S.C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Hellweg, R., Pless, O., Schulz, K.H., Gold, S.M.: Effects of exercise on irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of Neuroimmunology (2016) No. 299: 53-58 (

Brüne, B., Courtial, N., Dehne, N., Syed, S.N., Weigert, A.: Macrophage NOS2 in tumor leukocytes. Antioxidants & Redox Signaling. [Epub ahead of print] (

Bruin, N.M.W.J. de, Schmitz, K., Schiffmann, S., Tafferner, N., Schmidt, M., Jordan, H., Häußler, A., Tegeder, I., Geisslinger, G., Parnham, M.J.: Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behavioural Brain Research 300 (2016) 160-174 (

Bruin de, N.M.W.J., van Loevezijn, A., Wicke, K.M., de Haan, M., Venhorst, J., Lange, J.H.M., de Groote, L., van der Neut, M.A.W., Prickaerts, J., Andriambeloson, E., Foley, A.G., van Drimmelen, M., van der Wetering, M., Kruse, C.G.: The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment. Neurobiology of Learning and Memory (2016) No. 133: 100–117 ( )

Budu-Aggrey, A., Bowes, J. Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., Fitzgerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A.; Barton, A.: Replication of a distinct psoriatic arthritis risk variant at the IL23R locus. Annals of the rheumatic diseases 75 (2016) No. 7: 1417-1418 (

Budu-Aggrey, A., Bowes, J. Loehr, S., Uebe, S., Zervou, M.I., Helliwell, P., Ryan, A.W., Kane, D., Korendowych, E., Giardina, E., Packham, J., McManus, R., FitzGerald, O., McHugh, N., Behrens, F., Burkhardt, H., Huffmeier, U., Ho, P., Martin, J., Castaneda, S., Goulielmos, G., Reis, A., Barton, A.: Validation of a distinct psoriatic arthritis risk variant at IL23R. Rheumatology 55 (2016), Supplement 1, Abstract 219, i150-i151

Burkhardt, H., Weisenseel, P., Radtke, M.A., Krüger, K.: Hautmalignome und immunmodulierende Antirheumatikatherapie. Zeitschrift für Rheumatologie 75 (2016), No. 1: 32-40 (

Capelo, R., Lehmann, C., Ahmad, K., Snodgrass, R., Diehl, O., Ringleb, J., Flamand, N., Weigert, A., Stark, H., Steinhilber, D., Kahnt, A.S.: Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochemical pharmacology 103 (2016) 74-84 (

Combe, B., Behrens, F., McHugh, N., Brock, F., Kerkmann, U., Kola, B., Gallo, G.: Comparison of etanercept monotherapy and combination therapy with methotrexate in psoriatic arthritis: Results from 2 clinical trials. The Journal of Rheumatology 43 (2016) No. 6: 1063-1067 (


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de Araujo, L.S., Vaas, L.A., Ribeiro-Alves, M., Geffers, R., Mello, F.C., de Almeida, A.S., Moreira, A.D., Kritski, A.L., Lapa, E Silva JR, Moraes, M.O., Pessler, F., Saad, M.H.: Transcriptomic biomarkers for tuberculosis: Evaluation of DOCK9. EPHA4, and NPC2 mRNA expression in peripheral blood. Frontiers in Microbiology (2016) No. 7: 1586 (

Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Finl, A.F., Roberts, E., Brüne, B., Weigert, A.: S1PR4 signaling attenuates ILT7 internalization to limit IFN-a production by human plasmacytoid dendritic cells. The Journal of Immunology (2016) No. 196 (4): 1579-1590 (

Drebes, J., Künz, M., Windshügel, B., Kikhney, A.G., Müller, I.B., Eberle, R.J., Oberthür, D., Cang, H., Svergun, D.I., Perbandt, M., Betzel, C., Wrenger, C.: Structure of ThiM from vitamin B1 biosynthetic pathway of Staphylococcus aureus – insights into a novel pro-drug approach addressing MRSA infections. Scientific Reports (2016) No. 6: 22871 (

Ellinger, B., Gribbon P.: Risk mitigation in academic drug discovery. Expert Opinion on Drug Discovery (2016) No. 133(4): 333-336 (

Fenske, M., Gul, S.: Zebrafish early-life stages as neurological screening and detection tools. Drug Target Review, Volume 3, Autumn 2016, 41-43 (URL:

Frenz, T., Grabski, E., Buschjäger, D., Vaas, L.A., Burgdorf, N., Schmidt, R.E., Witte, T., Kalinke, U.: CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. The Journal of Allergy Clinical Immunology (2016) No. 138(2): 586-589.e10 (


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Graff, J., Scheuermann, E.H., Brandhorst, G., Oellerich, M., Gossmann, J.: Pharmacokinetic analysis of mycophenolate mofetil and enteric-coated mycophenolate sodium in calcineurin inhibitor-free renal transplant recipients. Ther Drug Monit. (2016) No. 38(3): 388-392 (

Grimm, M., Tischner, D., Troidl, K., Albarran Juarez, J., Sivaraj, K. K., Ferreiros Bouzas, N., Geisslinger, G., Binder, C. J., Wettschureck, N.: S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population. Arteriosclerosis, Thrombosis, and Vascular Biology 36 (2016) No. 1: 37-48 (

Hanke, T., Merk, D., Steinhilber, D., Geisslinger, G., Schubert-Zsilavecz, M.: Small molecules with anti-inflammatory properties in clinical development. Pharmacology & therapeutics 157 (2016) 163-87 (

Hauser, A.S., Windshügel, B.: LEADS-PEP: A benchmark data set for assessment of peptide docking performance. Journal of Chemical Information and Modeling 2016 Jan 25; No. 56(1): 188- 200 (

Henke, N., Ferreiros, N., Geisslinger, G., Ding, M. G., Essler, S., Fuhrmann, D. C., Geis, T., Namgaladze, D., Dehne, N., Brune, B.: Loss of HIF-1alpha in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model. Oncotarget 7 (2016) No. 18: 25915-29 (

Hunzelmann, N., Riemekasten, G., Becker, M.O., Moinzadeh, P., Kreuter, A., Melchers, I., Mueller-Ladner, U., Meier, F., Worm, M., Lee, H., Herrgott, I., Pfeiffer, C., Fierlbeck, G., Henes, J., Juche, A., Zeidler, G., Mensing, H., Günther, C., Sárdy, M., Burkhardt, H., Koehm, M., Kuhr, K., Krieg, T., Sunderkötter, C.: The Predict Study: low risk for digital ulcer development in patients with systemic sclerosis with increasing disease duration and lack of topoisomerase- 1 antibodies. The British Journal of Dermatology 174 (2016) No. 6: 1384-1387 (

Josipovic, I., Fork, C., Preussner, J., Prior, K. K., Iloska, D., Vasconez, A. E., Labocha, S., Angioni, C., Thomas, D., Ferreiros, N., Looso, M., Pullamsetti, S. S., Geisslinger, G. Steinhilber, D., Brandes, R. P., Leisegang, M. S.: PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells. Acta Physiologica 2018 (2016) No. 1: 13-27 (

Kemmerer, M., Wittig, I., Richter, F., Brüne, B., Namgaladze, D.: AMPK activates LXRa and ABCA1 expression in human macrophages. The International Journal of Biochemistry & Cell Biology (2016) No. 78: 1-9 (

King-Himmelreich, T.S., Schramm, S., Wolters, M.C., Schmetzer, J., Moser, C.V., Knothe, C., Resch, E., Peil, J., Geisslinger, G., Niederberger, E.: The impact of endurance exercise on global and AMPK gene-specific DNA methylation. Biochemical and Biophysical Research Communications 474 (2016) No. 2: 284-290 (

Klemmt, P.A., Resch, E., Smyrek, I., Engels, K., Stelzer, E.H., Starzinski-Powitz, A.: Alternative exon usage creates novel transcript variants of tumor suppressor SHREW-1 gene with differential tissue expression profile. Biology Open 15 (2016) No. 5(11), 1607-1619 (

Klingler, F.M., Wolf, M., Wittmann, S., Gribbon, P., Proschak, E.: Bacterial expression and HTS assessment of soluble epoxide hydrolase phosphatase. Journal of Biomolecular Screening (2016) No. 7: 689-94 (

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Kringel, D., Ultsch, A., Zimmermann, M. ,Jansen, J.P., Ilias, W., Freynhagen, R., Griessinger, N., Kopf, A., Stein, C., Doehring, A., Resch, E., Lotsch, J.: Emergent biomarker derived from next-generation sequencing to identify pain patients requiring uncommonly high opioid doses. Pharmacogenomics Journal (2016) 1-8 (

Loers, G., Saini, V., Mishra, B., Gul, S., Chaudhury, S., Wallqvist, A., Kaur, G., Schachner, M.: Vinorelbine and epirubicin share common features with polysialic acid and modulate neuronal and glial functions. Journal of Neurochemistry (2016) No. 136(1): 48-62 (

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Lötsch, J., Ultsch, A.: A computational functional genomics based self-limiting self-concentration mechanism of cell specialization as a biological role of jumping genes. Integrative Biology 8 (2016) No. 1: 91-103 (

Lötsch, J., Ultsch, A., Hummel, T.: How many and which odor identification items are needed to establish normal olfactory function? Chemical Senses 41 (2016) No. 4: 339-344 (

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Lötsch, J., Ultsch, A.: Process Pharmacology: A Pharmacological Data Science Approach to Drug Development and Therapy. CPT. Pharmacometrics & Systems Pharmacology 5 (2016), No. 4: 192-200 (

Lötsch, J., Dimova, V., Ultsch, A., Lieb, I., Zimmermann, M., Geisslinger, G., Oertel, B.G.: A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects. European Journal of Pain: EJP 20 (2016) No. 5: 777-789 (

Lötsch, J., Hähner, A., Gossrau, G., Hummel, C., Walter, C., Ultsch, A., Hummel, T.: Smell of paIntersection of nociception and olfaction. Pain 157 (2016) Nr. 10: 2152-2157 ( pain.0000000000000599)


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Mora, J., Schlemmer, A., Wittig, I., Richter, F., Putyrski, M., Frank, A.-C., Han, Y., Jung, M., Ernst, A., Weigert, A., Brüne, B.: Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses. J Mol Cell Biol 8 (2016), 426–438. (

Möser, C.V., Meissner, M., Laarmann, K., Olbrich, K., King-Himmelreich, T.S., Wolters, M.C., Geisslinger, G., Niederberger, E.: The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model. Biochemical Pharmacology 103 (2016), 64-73 (

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Ören, B., Urosevic, J., Mertens, C., Mora, J., Guiu, M., Gomis, R.R., Weigert, A., Schmid, T., Grein, S., Brüne, B., Jung, M.: Tumour stroma-derived lipocalin-2 promotes breast cancer metastasis. Journal of Pathology 239 (2016) No. 3: 274-285 (


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Parnham, M.J. (Ed.): Compendium of Inflammatory Diseases. Springer, Basel (2016). ISBN: 978-3- 0348-0620-6 (DOI 10.1007/978-3-7643-8550-7;

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Shiratori, H., Feinweber, C., Knothe, C., Lötsch, J., Geisslinger, G., Parnham, M.J., Resch, E.: High-throughput analysis of global DNA methylation using methyl sensitive digestion. PLOS ONE. Online journal 11(10): e0163184 (2016)  (

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Sisignano, M., Parnham, M.J., Geisslinger, G.: Drug repurposing for the development of novel analgesics. Trends in Pharmacological Sciences 37 (2016)172-83 (

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Wacker, M.G., Proykova, A., Santos, G.M.L.: Dealing with nanosafety around the globe – regulation vs. innovation. International Journal of Pharmaceutics 509 (2016) No.1-2: 95-106 (

Walter, C., Knothe, C., Lötsch, J.: Abuse-deterrent opioid formulations: pharmacokinetic and pharmacodynamic considerations. Clinical pharmacokinetics 55 (2016) No. 7, 751-767 (

Walter, C., Oertel, B.G., Felden, L., Kell, C.A., Nöth, U., Vermehren, J., Kaiser, J., Deichmann, R., Lötsch, J.: Brain mapping-based Model of D(9)-tetrahydrocannabinol effects on connectivity in the pain matrix. Neuropsychopharmacology. 2016 May;41(6):1659-69 (

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