Innovative Detection Technologies and Assay Designs

The Fraunhofer IME is an application-oriented research institute focusing on the development of innovative analytical platforms. We develop tailored solutions for specific challenges in close collaboration with partners from academia and industry.

One of the major fields of research at the Fraunhofer IME is the development of customized immunological assays and the production of specific antibodies for this purpose. As well as adapting classical procedures such as the enzyme-linked immunosorbent assay (ELISA) to address specific problems, we also focus on the development of innovative rapid testing platforms.

As an example, we are currently developing assays based on magnetic immunodetection. This analytical platform supports diverse applications in the field of bioanalytics and can be used for the analysis of individual samples and for high-throughput screening. The magnetic immunodetection assay involves the enrichment of the analyte inside an immunofiltration column and subsequent labeling with functionalized magnetic nanoparticles that can be quantified using a specialized detector. The resulting values provide a read-out of the analyte concentration. Magnetic immunodetection has a sensitivity of less than 1 ng/mL and takes less than 30 minutes to complete, which is significantly faster than an ELISA. The read out device has a compact design and is therefore portable.

We are also developing innovative analytical methods based on nucleic acid interactions such as hybridization and PCR, and we are investigating the first high throughput assays based on next-generation sequencing.

If you are interested in our services we can help to establish your specific analytical approach, so do not hesitate to contact us!